EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
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EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. / Weller, Michael; van den Bent, Martin; Preusser, Matthias; Le Rhun, Emilie; Tonn, Jörg C; Minniti, Giuseppe; Bendszus, Martin; Balana, Carmen; Chinot, Olivier; Dirven, Linda; French, Pim; Hegi, Monika E; Jakola, Asgeir S; Platten, Michael; Roth, Patrick; Rudà, Roberta; Short, Susan; Smits, Marion; Taphoorn, Martin J B; von Deimling, Andreas; Westphal, Manfred; Soffietti, Riccardo; Reifenberger, Guido; Wick, Wolfgang.
In: NAT REV CLIN ONCOL, Vol. 18, No. 3, 03.2021, p. 170-186.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
AU - Weller, Michael
AU - van den Bent, Martin
AU - Preusser, Matthias
AU - Le Rhun, Emilie
AU - Tonn, Jörg C
AU - Minniti, Giuseppe
AU - Bendszus, Martin
AU - Balana, Carmen
AU - Chinot, Olivier
AU - Dirven, Linda
AU - French, Pim
AU - Hegi, Monika E
AU - Jakola, Asgeir S
AU - Platten, Michael
AU - Roth, Patrick
AU - Rudà, Roberta
AU - Short, Susan
AU - Smits, Marion
AU - Taphoorn, Martin J B
AU - von Deimling, Andreas
AU - Westphal, Manfred
AU - Soffietti, Riccardo
AU - Reifenberger, Guido
AU - Wick, Wolfgang
PY - 2021/3
Y1 - 2021/3
N2 - In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. The diagnostic component is based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System and the subsequent recommendations of the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy - Not Officially WHO (cIMPACT-NOW). With regard to therapy, we formulated recommendations based on the results from the latest practice-changing clinical trials and also provide guidance for neuropathological and neuroradiological assessment. In these guidelines, we define the role of the major treatment modalities of surgery, radiotherapy and systemic pharmacotherapy, covering current advances and cognizant that unnecessary interventions and expenses should be avoided. This document is intended to be a source of reference for professionals involved in the management of adult patients with diffuse gliomas, for patients and caregivers, and for health-care providers.
AB - In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. The diagnostic component is based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System and the subsequent recommendations of the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy - Not Officially WHO (cIMPACT-NOW). With regard to therapy, we formulated recommendations based on the results from the latest practice-changing clinical trials and also provide guidance for neuropathological and neuroradiological assessment. In these guidelines, we define the role of the major treatment modalities of surgery, radiotherapy and systemic pharmacotherapy, covering current advances and cognizant that unnecessary interventions and expenses should be avoided. This document is intended to be a source of reference for professionals involved in the management of adult patients with diffuse gliomas, for patients and caregivers, and for health-care providers.
U2 - 10.1038/s41571-020-00447-z
DO - 10.1038/s41571-020-00447-z
M3 - SCORING: Review article
C2 - 33293629
VL - 18
SP - 170
EP - 186
JO - NAT REV CLIN ONCOL
JF - NAT REV CLIN ONCOL
SN - 1759-4774
IS - 3
ER -