Dyssynchrony, contractile function, and response to cardiac resynchronization therapy
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Dyssynchrony, contractile function, and response to cardiac resynchronization therapy. / Knappe, Dorit; Pouleur, Anne-Catherine; Shah, Amil M; Cheng, Susan; Uno, Hajime; Hall, W Jackson; Bourgoun, Mikhail; Foster, Elyse; Zareba, Wojciech; Goldenberg, Ilan; McNitt, Scott; Pfeffer, Marc A; Moss, Arthur J; Solomon, Scott D; Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy Investigators.
In: CIRC-HEART FAIL, Vol. 4, No. 4, 07.2011, p. 433-440.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dyssynchrony, contractile function, and response to cardiac resynchronization therapy
AU - Knappe, Dorit
AU - Pouleur, Anne-Catherine
AU - Shah, Amil M
AU - Cheng, Susan
AU - Uno, Hajime
AU - Hall, W Jackson
AU - Bourgoun, Mikhail
AU - Foster, Elyse
AU - Zareba, Wojciech
AU - Goldenberg, Ilan
AU - McNitt, Scott
AU - Pfeffer, Marc A
AU - Moss, Arthur J
AU - Solomon, Scott D
AU - Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy Investigators
PY - 2011/7
Y1 - 2011/7
N2 - BACKGROUND: Despite benefits of cardiac resynchronization therapy (CRT) in patients with severe but less symptomatic heart failure, approximately 30% of patients do not fully respond to treatment. We hypothesized that a combined assessment of left ventricular (LV) dyssynchrony and contractile function by strain-based imaging would identify patients who would most benefit from CRT.METHODS AND RESULTS: We studied 1077 patients with New York Heart Association class I/II, LV ejection fraction ≤30% and QRS width ≥130 ms enrolled in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy trial with sufficient echocardiographic image quality for cardiac deformation analysis (implantable cardioverter-defibrillator [ICD], n=416; CRT, n=661). Patients were assigned to CRT plus an ICD or to ICD alone in 3:2 random assignment. We assessed the degree to which baseline echocardiographic assessments of dyssynchrony, measured as the standard deviation of time-to-peak transverse strain over 12 segments, contractile function, measured as global longitudinal strain, or both predicted the effect of treatment on the primary outcome of death or heart failure. With 213 primary events occurring over a mean of 2.4 years, the benefit of CRT plus an ICD relative to ICD alone was greatest in patients with mild to moderate dyssynchrony (time-to-peak transverse strain standard deviation, 142 to 230 ms) and greater baseline contractile function (global longitudinal strain ≤-8.7%). Overall, those patients with mild to moderate dyssynchrony and those with best contractile function at baseline demonstrated the greatest benefit from CRT (adjusted hazards ratio, 0.20; 95% confidence interval, 0.09 to 0.44). Dyssynchrony and global longitudinal strain predicted response to CRT independent of each other, QRS width, LV ejection fraction, and presence versus absence of left bundle-branch block, although the observed benefit remained greatest in patients with left bundle-branch block.CONCLUSIONS: Both mechanical dyssynchrony and contractile function are important independent correlates of benefit from CRT.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00180271.
AB - BACKGROUND: Despite benefits of cardiac resynchronization therapy (CRT) in patients with severe but less symptomatic heart failure, approximately 30% of patients do not fully respond to treatment. We hypothesized that a combined assessment of left ventricular (LV) dyssynchrony and contractile function by strain-based imaging would identify patients who would most benefit from CRT.METHODS AND RESULTS: We studied 1077 patients with New York Heart Association class I/II, LV ejection fraction ≤30% and QRS width ≥130 ms enrolled in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy trial with sufficient echocardiographic image quality for cardiac deformation analysis (implantable cardioverter-defibrillator [ICD], n=416; CRT, n=661). Patients were assigned to CRT plus an ICD or to ICD alone in 3:2 random assignment. We assessed the degree to which baseline echocardiographic assessments of dyssynchrony, measured as the standard deviation of time-to-peak transverse strain over 12 segments, contractile function, measured as global longitudinal strain, or both predicted the effect of treatment on the primary outcome of death or heart failure. With 213 primary events occurring over a mean of 2.4 years, the benefit of CRT plus an ICD relative to ICD alone was greatest in patients with mild to moderate dyssynchrony (time-to-peak transverse strain standard deviation, 142 to 230 ms) and greater baseline contractile function (global longitudinal strain ≤-8.7%). Overall, those patients with mild to moderate dyssynchrony and those with best contractile function at baseline demonstrated the greatest benefit from CRT (adjusted hazards ratio, 0.20; 95% confidence interval, 0.09 to 0.44). Dyssynchrony and global longitudinal strain predicted response to CRT independent of each other, QRS width, LV ejection fraction, and presence versus absence of left bundle-branch block, although the observed benefit remained greatest in patients with left bundle-branch block.CONCLUSIONS: Both mechanical dyssynchrony and contractile function are important independent correlates of benefit from CRT.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00180271.
KW - Aged
KW - Canada
KW - Cardiac Resynchronization Therapy
KW - Defibrillators, Implantable
KW - Echocardiography
KW - Electrocardiography
KW - Europe
KW - Female
KW - Heart Failure/physiopathology
KW - Humans
KW - Male
KW - Middle Aged
KW - Myocardial Contraction/physiology
KW - Retrospective Studies
KW - Stroke Volume/physiology
KW - Treatment Outcome
KW - United States
KW - Ventricular Dysfunction, Left/physiopathology
U2 - 10.1161/CIRCHEARTFAILURE.111.962902
DO - 10.1161/CIRCHEARTFAILURE.111.962902
M3 - SCORING: Journal article
C2 - 21602574
VL - 4
SP - 433
EP - 440
JO - CIRC-HEART FAIL
JF - CIRC-HEART FAIL
SN - 1941-3289
IS - 4
ER -