Research ExplorerPublicationsDysregulated T helper cell differentiation in the absence of...

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4

Standard

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. / Lohoff, Michael; Mittrücker, Hans-Willi; Prechtl, Stefan; Bischof, Susi; Sommer, Frank; Kock, Sonja; Ferrick, David A; Duncan, Gordon S; Gessner, Andre; Mak, Tak W.

In: P NATL ACAD SCI USA, Vol. 99, No. 18, 03.09.2002, p. 11808-12.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lohoff, M, Mittrücker, H-W, Prechtl, S, Bischof, S, Sommer, F, Kock, S, Ferrick, DA, Duncan, GS, Gessner, A & Mak, TW 2002, 'Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4', P NATL ACAD SCI USA, vol. 99, no. 18, pp. 11808-12. https://doi.org/10.1073/pnas.182425099

APA

Lohoff, M., Mittrücker, H-W., Prechtl, S., Bischof, S., Sommer, F., Kock, S., Ferrick, D. A., Duncan, G. S., Gessner, A., & Mak, T. W. (2002). Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. P NATL ACAD SCI USA, 99(18), 11808-12. https://doi.org/10.1073/pnas.182425099

Vancouver

Lohoff M, Mittrücker H-W, Prechtl S, Bischof S, Sommer F, Kock S et al. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. P NATL ACAD SCI USA. 2002 Sep 3;99(18):11808-12. https://doi.org/10.1073/pnas.182425099

Bibtex

@article{fc663a3b00c948f2aeb89df8ac0e680f,
title = "Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4",
abstract = "Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating the production of IL-12. Here, we show that IRF4 directly regulates Th cell differentiation in vitro and in vivo during murine leishmaniasis. In the absence of IRF4, IL-12-induced Th1 cell differentiation was compromised, while IL-4 failed to induce Th2 cell differentiation. Instead, IL-4 tended to induce Th1 cells, defined by production of IFN-gamma and TNF. Although early IL-4 signaling was normal in IRF4(-/-) Th cells, the protein GATA-3, a transcription factor critical for Th2 development, was not up-regulated following IL-4 treatment. Retroviral overexpression of GATA-3 rescued Th2 differentiation. Therefore, IRF4 deficiency manifests itself as severely dysregulated Th cell differentiation.",
keywords = "Animals, Blotting, Western, Cell Differentiation, DNA-Binding Proteins, GATA3 Transcription Factor, Gene Expression Regulation, Interferon Regulatory Factors, Interleukin-4, Leishmaniasis, Mice, Mice, Inbred C57BL, Phosphorylation, STAT6 Transcription Factor, T-Lymphocytes, Helper-Inducer, Trans-Activators, Transcription Factors",
author = "Michael Lohoff and Hans-Willi Mittr{\"u}cker and Stefan Prechtl and Susi Bischof and Frank Sommer and Sonja Kock and Ferrick, {David A} and Duncan, {Gordon S} and Andre Gessner and Mak, {Tak W}",
year = "2002",
month = sep,
day = "3",
doi = "10.1073/pnas.182425099",
language = "English",
volume = "99",
pages = "11808--12",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "18",

}

RIS

TY - JOUR

T1 - Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4

AU - Lohoff, Michael

AU - Mittrücker, Hans-Willi

AU - Prechtl, Stefan

AU - Bischof, Susi

AU - Sommer, Frank

AU - Kock, Sonja

AU - Ferrick, David A

AU - Duncan, Gordon S

AU - Gessner, Andre

AU - Mak, Tak W

PY - 2002/9/3

Y1 - 2002/9/3

N2 - Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating the production of IL-12. Here, we show that IRF4 directly regulates Th cell differentiation in vitro and in vivo during murine leishmaniasis. In the absence of IRF4, IL-12-induced Th1 cell differentiation was compromised, while IL-4 failed to induce Th2 cell differentiation. Instead, IL-4 tended to induce Th1 cells, defined by production of IFN-gamma and TNF. Although early IL-4 signaling was normal in IRF4(-/-) Th cells, the protein GATA-3, a transcription factor critical for Th2 development, was not up-regulated following IL-4 treatment. Retroviral overexpression of GATA-3 rescued Th2 differentiation. Therefore, IRF4 deficiency manifests itself as severely dysregulated Th cell differentiation.

AB - Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating the production of IL-12. Here, we show that IRF4 directly regulates Th cell differentiation in vitro and in vivo during murine leishmaniasis. In the absence of IRF4, IL-12-induced Th1 cell differentiation was compromised, while IL-4 failed to induce Th2 cell differentiation. Instead, IL-4 tended to induce Th1 cells, defined by production of IFN-gamma and TNF. Although early IL-4 signaling was normal in IRF4(-/-) Th cells, the protein GATA-3, a transcription factor critical for Th2 development, was not up-regulated following IL-4 treatment. Retroviral overexpression of GATA-3 rescued Th2 differentiation. Therefore, IRF4 deficiency manifests itself as severely dysregulated Th cell differentiation.

KW - Animals

KW - Blotting, Western

KW - Cell Differentiation

KW - DNA-Binding Proteins

KW - GATA3 Transcription Factor

KW - Gene Expression Regulation

KW - Interferon Regulatory Factors

KW - Interleukin-4

KW - Leishmaniasis

KW - Mice

KW - Mice, Inbred C57BL

KW - Phosphorylation

KW - STAT6 Transcription Factor

KW - T-Lymphocytes, Helper-Inducer

KW - Trans-Activators

KW - Transcription Factors

U2 - 10.1073/pnas.182425099

DO - 10.1073/pnas.182425099

M3 - SCORING: Journal article

C2 - 12189207

VL - 99

SP - 11808

EP - 11812

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 18

ER -