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Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome

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Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome. / Oh, Jun; Reiser, Jochen; Mundel, Peter.

In: PEDIATR NEPHROL, Vol. 19, No. 2, 02.2004, p. 130-7.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Oh, J, Reiser, J & Mundel, P 2004, 'Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome', PEDIATR NEPHROL, vol. 19, no. 2, pp. 130-7. https://doi.org/10.1007/s00467-003-1367-y

APA

Oh, J., Reiser, J., & Mundel, P. (2004). Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome. PEDIATR NEPHROL, 19(2), 130-7. https://doi.org/10.1007/s00467-003-1367-y

Vancouver

Oh J, Reiser J, Mundel P. Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome. PEDIATR NEPHROL. 2004 Feb;19(2):130-7. https://doi.org/10.1007/s00467-003-1367-y

Bibtex

@article{de3c1b6568574c658eab7ca3140f9e5e,
title = "Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome",
abstract = "The visceral glomerular epithelial cell, also known as the podocyte, plays an important role in the maintenance of renal glomerular function. This cell type is highly specialized and its foot processes together with the interposed slit diaphragm (SD) form the final barrier to urinary protein loss. Effacement of foot processes is associated with the development of proteinuria and-if not reversed in a certain time-with permanent deterioration of the glomerular filter. To maintain an intact glomerular filter barrier, podocyte-podocyte interactions and podocyte interactions with the glomerular basement membrane (GBM) are essential. Recent years have highlighted podocyte functions by unraveling the molecular composition of the SD, but have also clarified the important role of the podocyte actin cytoskeleton, and the podocyte-GBM interaction in the development of foot process (FP) effacement. This review provides an update of podocyte functions with respect to novel podocyte-specific proteins and also focuses on the dynamic interaction between the actin cytoskeleton of podocytes, their cell surface receptors and the GBM.",
keywords = "Actins/metabolism, Animals, Cytoskeleton/ultrastructure, Epithelial Cells/ultrastructure, Humans, Kidney Glomerulus/pathology, Nephrotic Syndrome/pathology, Proteinuria/prevention & control",
author = "Jun Oh and Jochen Reiser and Peter Mundel",
year = "2004",
month = feb,
doi = "10.1007/s00467-003-1367-y",
language = "English",
volume = "19",
pages = "130--7",
journal = "PEDIATR NEPHROL",
issn = "0931-041X",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome

AU - Oh, Jun

AU - Reiser, Jochen

AU - Mundel, Peter

PY - 2004/2

Y1 - 2004/2

N2 - The visceral glomerular epithelial cell, also known as the podocyte, plays an important role in the maintenance of renal glomerular function. This cell type is highly specialized and its foot processes together with the interposed slit diaphragm (SD) form the final barrier to urinary protein loss. Effacement of foot processes is associated with the development of proteinuria and-if not reversed in a certain time-with permanent deterioration of the glomerular filter. To maintain an intact glomerular filter barrier, podocyte-podocyte interactions and podocyte interactions with the glomerular basement membrane (GBM) are essential. Recent years have highlighted podocyte functions by unraveling the molecular composition of the SD, but have also clarified the important role of the podocyte actin cytoskeleton, and the podocyte-GBM interaction in the development of foot process (FP) effacement. This review provides an update of podocyte functions with respect to novel podocyte-specific proteins and also focuses on the dynamic interaction between the actin cytoskeleton of podocytes, their cell surface receptors and the GBM.

AB - The visceral glomerular epithelial cell, also known as the podocyte, plays an important role in the maintenance of renal glomerular function. This cell type is highly specialized and its foot processes together with the interposed slit diaphragm (SD) form the final barrier to urinary protein loss. Effacement of foot processes is associated with the development of proteinuria and-if not reversed in a certain time-with permanent deterioration of the glomerular filter. To maintain an intact glomerular filter barrier, podocyte-podocyte interactions and podocyte interactions with the glomerular basement membrane (GBM) are essential. Recent years have highlighted podocyte functions by unraveling the molecular composition of the SD, but have also clarified the important role of the podocyte actin cytoskeleton, and the podocyte-GBM interaction in the development of foot process (FP) effacement. This review provides an update of podocyte functions with respect to novel podocyte-specific proteins and also focuses on the dynamic interaction between the actin cytoskeleton of podocytes, their cell surface receptors and the GBM.

KW - Actins/metabolism

KW - Animals

KW - Cytoskeleton/ultrastructure

KW - Epithelial Cells/ultrastructure

KW - Humans

KW - Kidney Glomerulus/pathology

KW - Nephrotic Syndrome/pathology

KW - Proteinuria/prevention & control

U2 - 10.1007/s00467-003-1367-y

DO - 10.1007/s00467-003-1367-y

M3 - SCORING: Review article

C2 - 14673634

VL - 19

SP - 130

EP - 137

JO - PEDIATR NEPHROL

JF - PEDIATR NEPHROL

SN - 0931-041X

IS - 2

ER -