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Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner

Standard

Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner. / Ulmer, Stephan; Reeh, Matthias; Krause, Joerg; Herdegen, Thomas; Heldt-Feindt, Janka; Jansen, Olav; Rohr, Axel.

In: J NEUROSCI METH, Vol. 172, No. 2, 30.07.2008, p. 168-72.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ulmer, S, Reeh, M, Krause, J, Herdegen, T, Heldt-Feindt, J, Jansen, O & Rohr, A 2008, 'Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner', J NEUROSCI METH, vol. 172, no. 2, pp. 168-72. https://doi.org/10.1016/j.jneumeth.2008.04.022

APA

Ulmer, S., Reeh, M., Krause, J., Herdegen, T., Heldt-Feindt, J., Jansen, O., & Rohr, A. (2008). Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner. J NEUROSCI METH, 172(2), 168-72. https://doi.org/10.1016/j.jneumeth.2008.04.022

Vancouver

Ulmer S, Reeh M, Krause J, Herdegen T, Heldt-Feindt J, Jansen O et al. Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner. J NEUROSCI METH. 2008 Jul 30;172(2):168-72. https://doi.org/10.1016/j.jneumeth.2008.04.022

Bibtex

@article{e89b80f1f4744311b321c26b780da837,
title = "Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner",
abstract = "Magnetic resonance (MR) imaging in animal models is usually performed in expensive dedicated small bore animal scanners of limited availability. In the present study a standard clinical 1.5 T MR scanner was used for morphometric and dynamic contrast-enhanced susceptibility-weighted MR imaging (DSC-MRI) of a glioma model of the rat brain. Ten male Wistar rats were examined with coronal T2-weighted, and T1-weighted images (matrix 128 x 128, FOV 64 mm) after implantation of an intracerebral tumor xenografts (C6) using a conventional surface coil. For DSC-MRI a T2*-weighted sequence (TR/TE=30/14 ms, matrix 64 x 64, FOV 90 mm; slice thickness of 1.5mm) was performed. Regions of interest were defined within the tumor and the non-affected contralateral hemisphere and the mean transit time (MTT) was determined. Tumor dimensions in MR predicted well its real size as proven by histology. The MTT of contrast agent passing through the brain was significantly decelerated in the tumor compared to the unaffected hemisphere (p<0.001, paired t-test), which is most likely due to the leakage of contrast agent through the disrupted blood brain barrier. This setup offers advanced MR imaging of small animals without the need for dedicated animal scanners or dedicated custom-made coils.",
keywords = "Animals, Brain, Brain Neoplasms, Cell Line, Tumor, Contrast Media, Disease Models, Animal, Glioma, Graft Survival, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neoplasm Transplantation, Phantoms, Imaging, Rats, Rats, Wistar, Time Factors",
author = "Stephan Ulmer and Matthias Reeh and Joerg Krause and Thomas Herdegen and Janka Heldt-Feindt and Olav Jansen and Axel Rohr",
year = "2008",
month = jul,
day = "30",
doi = "10.1016/j.jneumeth.2008.04.022",
language = "English",
volume = "172",
pages = "168--72",
journal = "J NEUROSCI METH",
issn = "0165-0270",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner

AU - Ulmer, Stephan

AU - Reeh, Matthias

AU - Krause, Joerg

AU - Herdegen, Thomas

AU - Heldt-Feindt, Janka

AU - Jansen, Olav

AU - Rohr, Axel

PY - 2008/7/30

Y1 - 2008/7/30

N2 - Magnetic resonance (MR) imaging in animal models is usually performed in expensive dedicated small bore animal scanners of limited availability. In the present study a standard clinical 1.5 T MR scanner was used for morphometric and dynamic contrast-enhanced susceptibility-weighted MR imaging (DSC-MRI) of a glioma model of the rat brain. Ten male Wistar rats were examined with coronal T2-weighted, and T1-weighted images (matrix 128 x 128, FOV 64 mm) after implantation of an intracerebral tumor xenografts (C6) using a conventional surface coil. For DSC-MRI a T2*-weighted sequence (TR/TE=30/14 ms, matrix 64 x 64, FOV 90 mm; slice thickness of 1.5mm) was performed. Regions of interest were defined within the tumor and the non-affected contralateral hemisphere and the mean transit time (MTT) was determined. Tumor dimensions in MR predicted well its real size as proven by histology. The MTT of contrast agent passing through the brain was significantly decelerated in the tumor compared to the unaffected hemisphere (p<0.001, paired t-test), which is most likely due to the leakage of contrast agent through the disrupted blood brain barrier. This setup offers advanced MR imaging of small animals without the need for dedicated animal scanners or dedicated custom-made coils.

AB - Magnetic resonance (MR) imaging in animal models is usually performed in expensive dedicated small bore animal scanners of limited availability. In the present study a standard clinical 1.5 T MR scanner was used for morphometric and dynamic contrast-enhanced susceptibility-weighted MR imaging (DSC-MRI) of a glioma model of the rat brain. Ten male Wistar rats were examined with coronal T2-weighted, and T1-weighted images (matrix 128 x 128, FOV 64 mm) after implantation of an intracerebral tumor xenografts (C6) using a conventional surface coil. For DSC-MRI a T2*-weighted sequence (TR/TE=30/14 ms, matrix 64 x 64, FOV 90 mm; slice thickness of 1.5mm) was performed. Regions of interest were defined within the tumor and the non-affected contralateral hemisphere and the mean transit time (MTT) was determined. Tumor dimensions in MR predicted well its real size as proven by histology. The MTT of contrast agent passing through the brain was significantly decelerated in the tumor compared to the unaffected hemisphere (p<0.001, paired t-test), which is most likely due to the leakage of contrast agent through the disrupted blood brain barrier. This setup offers advanced MR imaging of small animals without the need for dedicated animal scanners or dedicated custom-made coils.

KW - Animals

KW - Brain

KW - Brain Neoplasms

KW - Cell Line, Tumor

KW - Contrast Media

KW - Disease Models, Animal

KW - Glioma

KW - Graft Survival

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Neoplasm Transplantation

KW - Phantoms, Imaging

KW - Rats

KW - Rats, Wistar

KW - Time Factors

U2 - 10.1016/j.jneumeth.2008.04.022

DO - 10.1016/j.jneumeth.2008.04.022

M3 - SCORING: Journal article

C2 - 18538856

VL - 172

SP - 168

EP - 172

JO - J NEUROSCI METH

JF - J NEUROSCI METH

SN - 0165-0270

IS - 2

ER -