Dynamic changes in white matter microstructure in anorexia nervosa: findings from a longitudinal study
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Dynamic changes in white matter microstructure in anorexia nervosa: findings from a longitudinal study. / von Schwanenflug, Nina; Müller, Dirk K; King, Joseph A; Ritschel, Franziska; Bernardoni, Fabio; Mohammadi, Siawoosh; Geisler, Daniel; Roessner, Veit; Biemann, Ronald; Marxen, Michael; Ehrlich, Stefan.
In: PSYCHOL MED, Vol. 49, No. 9, 07.2019, p. 1555-1564.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dynamic changes in white matter microstructure in anorexia nervosa: findings from a longitudinal study
AU - von Schwanenflug, Nina
AU - Müller, Dirk K
AU - King, Joseph A
AU - Ritschel, Franziska
AU - Bernardoni, Fabio
AU - Mohammadi, Siawoosh
AU - Geisler, Daniel
AU - Roessner, Veit
AU - Biemann, Ronald
AU - Marxen, Michael
AU - Ehrlich, Stefan
PY - 2019/7
Y1 - 2019/7
N2 - BACKGROUND: Gray matter (GM) 'pseudoatrophy' is well-documented in patients with anorexia nervosa (AN), but changes in white matter (WM) are less well understood. Here we investigated the dynamics of microstructural WM brain changes in AN patients during short-term weight restoration in a combined longitudinal and cross-sectional study design.METHODS: Diffusion-weighted images were acquired in young AN patients before (acAN-Tp1, n = 56) and after (acAN-Tp2, n = 44) short-term weight restoration as well as in age-matched healthy controls (HC, n = 60). Images were processed using Tract-Based-Spatial-Statistics to compare fractional anisotropy (FA) across groups and timepoints.RESULTS: In the cross-sectional comparison, FA was significantly reduced in the callosal body in acAN-Tp1 compared with HC, while no differences were found between acAN-Tp2 and HC. In the longitudinal arm, FA increased with weight gain in acAN-Tp2 relative to acAN-Tp1 in large parts of the callosal body and the fornix, while it decreased in the right corticospinal tract.CONCLUSIONS: Our findings reveal that dynamic, bidirectional changes in WM microstructure in young underweight patients with AN can be reversed with brief weight restoration therapy. These results parallel those previously observed in GM and suggest that alterations in WM in non-chronic AN are also state-dependent and rapidly reversible with successful intervention.
AB - BACKGROUND: Gray matter (GM) 'pseudoatrophy' is well-documented in patients with anorexia nervosa (AN), but changes in white matter (WM) are less well understood. Here we investigated the dynamics of microstructural WM brain changes in AN patients during short-term weight restoration in a combined longitudinal and cross-sectional study design.METHODS: Diffusion-weighted images were acquired in young AN patients before (acAN-Tp1, n = 56) and after (acAN-Tp2, n = 44) short-term weight restoration as well as in age-matched healthy controls (HC, n = 60). Images were processed using Tract-Based-Spatial-Statistics to compare fractional anisotropy (FA) across groups and timepoints.RESULTS: In the cross-sectional comparison, FA was significantly reduced in the callosal body in acAN-Tp1 compared with HC, while no differences were found between acAN-Tp2 and HC. In the longitudinal arm, FA increased with weight gain in acAN-Tp2 relative to acAN-Tp1 in large parts of the callosal body and the fornix, while it decreased in the right corticospinal tract.CONCLUSIONS: Our findings reveal that dynamic, bidirectional changes in WM microstructure in young underweight patients with AN can be reversed with brief weight restoration therapy. These results parallel those previously observed in GM and suggest that alterations in WM in non-chronic AN are also state-dependent and rapidly reversible with successful intervention.
KW - Journal Article
U2 - 10.1017/S003329171800212X
DO - 10.1017/S003329171800212X
M3 - SCORING: Journal article
C2 - 30149815
VL - 49
SP - 1555
EP - 1564
JO - PSYCHOL MED
JF - PSYCHOL MED
SN - 0033-2917
IS - 9
ER -
