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Duration of the cue-to-pain delay increases pain intensity: a combined EEG and MEG study.

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Duration of the cue-to-pain delay increases pain intensity: a combined EEG and MEG study. / Hauck, Michael; Lorenz, Jürgen; Zimmermann, Roger; Debener, Stefan; Scharein, Eckehard; Engel, Andreas K.

In: EXP BRAIN RES, Vol. 180, No. 2, 2, 01.06.2007, p. 205-215.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hauck, M, Lorenz, J, Zimmermann, R, Debener, S, Scharein, E & Engel, AK 2007, 'Duration of the cue-to-pain delay increases pain intensity: a combined EEG and MEG study.', EXP BRAIN RES, vol. 180, no. 2, 2, pp. 205-215. https://doi.org/10.1007/s00221-007-0863-x

APA

Hauck, M., Lorenz, J., Zimmermann, R., Debener, S., Scharein, E., & Engel, A. K. (2007). Duration of the cue-to-pain delay increases pain intensity: a combined EEG and MEG study. EXP BRAIN RES, 180(2), 205-215. [2]. https://doi.org/10.1007/s00221-007-0863-x

Vancouver

Hauck M, Lorenz J, Zimmermann R, Debener S, Scharein E, Engel AK. Duration of the cue-to-pain delay increases pain intensity: a combined EEG and MEG study. EXP BRAIN RES. 2007 Jun 1;180(2):205-215. 2. https://doi.org/10.1007/s00221-007-0863-x

Bibtex

@article{5f7d1b32d68041bbb8c6c8f632cc8bf6,
title = "Duration of the cue-to-pain delay increases pain intensity: a combined EEG and MEG study.",
abstract = "Expectation of pain is an important adaptive process enabling individuals to avoid bodily harm. It reflects the linking of past experience and environmental cues with imminent threat. In the present study, we examined changes in perceived pain contingent upon variation of the interval between an auditory cue and a subsequent painful laser stimulus. The duration of the cue-to-stimulus delay was systematically varied between 2, 4 and 6 s. Pain intensity and evoked brain responses measured by EEG and MEG recordings were analysed. Pain ratings from 15 subjects increased with longer cue-to-pain delays, accompanied by an increase in activity of the midcingulate cortex (MCC), as modelled from evoked EEG potential maps. On the other hand, MEG-based source activity in secondary somatosensory (SII) cortex remained unaffected by manipulation of the cue-to-stimulus interval. We conclude that activity in limbic structures such as MCC play a key role in the temporal dynamics of recruitment of expectation towards pain. Although this reaction is adaptive if the individual is able to avoid the stimulus, it is maladaptive if such opportunity is not present.",
keywords = "Adult, Analysis of Variance, Brain Mapping, Cues, Electroencephalography, Evoked Potentials, Somatosensory, Humans, Magnetoencephalography, Male, Pain, Pain Measurement, Pain Threshold, Psychophysics, Reaction Time, Somatosensory Cortex",
author = "Michael Hauck and J{\"u}rgen Lorenz and Roger Zimmermann and Stefan Debener and Eckehard Scharein and Engel, {Andreas K}",
year = "2007",
month = jun,
day = "1",
doi = "10.1007/s00221-007-0863-x",
language = "English",
volume = "180",
pages = "205--215",
journal = "EXP BRAIN RES",
issn = "0014-4819",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Duration of the cue-to-pain delay increases pain intensity: a combined EEG and MEG study.

AU - Hauck, Michael

AU - Lorenz, Jürgen

AU - Zimmermann, Roger

AU - Debener, Stefan

AU - Scharein, Eckehard

AU - Engel, Andreas K

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Expectation of pain is an important adaptive process enabling individuals to avoid bodily harm. It reflects the linking of past experience and environmental cues with imminent threat. In the present study, we examined changes in perceived pain contingent upon variation of the interval between an auditory cue and a subsequent painful laser stimulus. The duration of the cue-to-stimulus delay was systematically varied between 2, 4 and 6 s. Pain intensity and evoked brain responses measured by EEG and MEG recordings were analysed. Pain ratings from 15 subjects increased with longer cue-to-pain delays, accompanied by an increase in activity of the midcingulate cortex (MCC), as modelled from evoked EEG potential maps. On the other hand, MEG-based source activity in secondary somatosensory (SII) cortex remained unaffected by manipulation of the cue-to-stimulus interval. We conclude that activity in limbic structures such as MCC play a key role in the temporal dynamics of recruitment of expectation towards pain. Although this reaction is adaptive if the individual is able to avoid the stimulus, it is maladaptive if such opportunity is not present.

AB - Expectation of pain is an important adaptive process enabling individuals to avoid bodily harm. It reflects the linking of past experience and environmental cues with imminent threat. In the present study, we examined changes in perceived pain contingent upon variation of the interval between an auditory cue and a subsequent painful laser stimulus. The duration of the cue-to-stimulus delay was systematically varied between 2, 4 and 6 s. Pain intensity and evoked brain responses measured by EEG and MEG recordings were analysed. Pain ratings from 15 subjects increased with longer cue-to-pain delays, accompanied by an increase in activity of the midcingulate cortex (MCC), as modelled from evoked EEG potential maps. On the other hand, MEG-based source activity in secondary somatosensory (SII) cortex remained unaffected by manipulation of the cue-to-stimulus interval. We conclude that activity in limbic structures such as MCC play a key role in the temporal dynamics of recruitment of expectation towards pain. Although this reaction is adaptive if the individual is able to avoid the stimulus, it is maladaptive if such opportunity is not present.

KW - Adult

KW - Analysis of Variance

KW - Brain Mapping

KW - Cues

KW - Electroencephalography

KW - Evoked Potentials, Somatosensory

KW - Humans

KW - Magnetoencephalography

KW - Male

KW - Pain

KW - Pain Measurement

KW - Pain Threshold

KW - Psychophysics

KW - Reaction Time

KW - Somatosensory Cortex

U2 - 10.1007/s00221-007-0863-x

DO - 10.1007/s00221-007-0863-x

M3 - SCORING: Journal article

C2 - 17287993

VL - 180

SP - 205

EP - 215

JO - EXP BRAIN RES

JF - EXP BRAIN RES

SN - 0014-4819

IS - 2

M1 - 2

ER -