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Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate

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Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. / von Felden, Johann; Montani, Matteo; Kessebohm, Kerstin; Stickel, Felix.

In: INT J CLIN PHARM TH, Vol. 51, No. 3, 03.2013, p. 219-23.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

von Felden, J, Montani, M, Kessebohm, K & Stickel, F 2013, 'Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate', INT J CLIN PHARM TH, vol. 51, no. 3, pp. 219-23. https://doi.org/10.5414/CP201835

APA

von Felden, J., Montani, M., Kessebohm, K., & Stickel, F. (2013). Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. INT J CLIN PHARM TH, 51(3), 219-23. https://doi.org/10.5414/CP201835

Vancouver

von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. INT J CLIN PHARM TH. 2013 Mar;51(3):219-23. https://doi.org/10.5414/CP201835

Bibtex

@article{886e01794f71485c880ded4edc149b17,
title = "Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate",
abstract = "INTRODUCTION: Herbal and dietary supplements are widely used as measures to improve and preserve health and well-being. Among the bestselling preparations are dietary supplement containing glucosamine and chondroitine sulfate taken to improve symptoms of osteoarthritis.METHODS AND RESULTS: We here present a case of a male patient with biopsy-proven acute and severe autoimmune hepatitis subsequent to intake of a preparation containing glucosamine and chondroitine sulfate. Response to steroids was favorable and resulted in complete remission of the patient. Diagnostic work-up of the case revealed no other possible cause of liver injury, and causality assessment using the Roussel Uclaf Causality Assessment Method (RUCAM) resulted in a possible causal relationship between intake of glucosamine and chondroitine sulfate and the adverse hepatic reaction.CONCLUSION: The present case recalls that products containing glucosamine and chondroitine sulfate can occasionally cause acute liver injury mimicking autoimmune hepatitis, and reminds of the potential dangers of compounds with poor efficacy and ill-defined safety records.",
keywords = "Acute Disease, Aged, Chemical and Drug Induced Liver Injury, Chondroitin Sulfates, Diagnosis, Differential, Dietary Supplements, Glucosamine, Hepatitis, Autoimmune, Humans, Male, Case Reports, Journal Article",
author = "{von Felden}, Johann and Matteo Montani and Kerstin Kessebohm and Felix Stickel",
year = "2013",
month = mar,
doi = "10.5414/CP201835",
language = "English",
volume = "51",
pages = "219--23",
number = "3",

}

RIS

TY - JOUR

T1 - Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate

AU - von Felden, Johann

AU - Montani, Matteo

AU - Kessebohm, Kerstin

AU - Stickel, Felix

PY - 2013/3

Y1 - 2013/3

N2 - INTRODUCTION: Herbal and dietary supplements are widely used as measures to improve and preserve health and well-being. Among the bestselling preparations are dietary supplement containing glucosamine and chondroitine sulfate taken to improve symptoms of osteoarthritis.METHODS AND RESULTS: We here present a case of a male patient with biopsy-proven acute and severe autoimmune hepatitis subsequent to intake of a preparation containing glucosamine and chondroitine sulfate. Response to steroids was favorable and resulted in complete remission of the patient. Diagnostic work-up of the case revealed no other possible cause of liver injury, and causality assessment using the Roussel Uclaf Causality Assessment Method (RUCAM) resulted in a possible causal relationship between intake of glucosamine and chondroitine sulfate and the adverse hepatic reaction.CONCLUSION: The present case recalls that products containing glucosamine and chondroitine sulfate can occasionally cause acute liver injury mimicking autoimmune hepatitis, and reminds of the potential dangers of compounds with poor efficacy and ill-defined safety records.

AB - INTRODUCTION: Herbal and dietary supplements are widely used as measures to improve and preserve health and well-being. Among the bestselling preparations are dietary supplement containing glucosamine and chondroitine sulfate taken to improve symptoms of osteoarthritis.METHODS AND RESULTS: We here present a case of a male patient with biopsy-proven acute and severe autoimmune hepatitis subsequent to intake of a preparation containing glucosamine and chondroitine sulfate. Response to steroids was favorable and resulted in complete remission of the patient. Diagnostic work-up of the case revealed no other possible cause of liver injury, and causality assessment using the Roussel Uclaf Causality Assessment Method (RUCAM) resulted in a possible causal relationship between intake of glucosamine and chondroitine sulfate and the adverse hepatic reaction.CONCLUSION: The present case recalls that products containing glucosamine and chondroitine sulfate can occasionally cause acute liver injury mimicking autoimmune hepatitis, and reminds of the potential dangers of compounds with poor efficacy and ill-defined safety records.

KW - Acute Disease

KW - Aged

KW - Chemical and Drug Induced Liver Injury

KW - Chondroitin Sulfates

KW - Diagnosis, Differential

KW - Dietary Supplements

KW - Glucosamine

KW - Hepatitis, Autoimmune

KW - Humans

KW - Male

KW - Case Reports

KW - Journal Article

U2 - 10.5414/CP201835

DO - 10.5414/CP201835

M3 - SCORING: Journal article

C2 - 23391366

VL - 51

SP - 219

EP - 223

IS - 3

ER -