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Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial

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Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial. / Fahrni, Gregor; Scheller, Bruno; Coslovsky, Michael; Gilgen, Nicole; Farah, Ahmed; Ohlow, Marc-Alexander; Mangner, Norman; Weilenmann, Daniel; Wöhrle, Jochen; Cuculi, Florim; Leibundgut, Gregor; Möbius-Winkler, Sven; Zweiker, Robert; Twerenbold, Raphael; Kaiser, Christoph; Jeger, Raban; BASKET-SMALL 2 Investigators.

In: CLIN RES CARDIOL, Vol. 109, No. 9, 09.2020, p. 1114-1124.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fahrni, G, Scheller, B, Coslovsky, M, Gilgen, N, Farah, A, Ohlow, M-A, Mangner, N, Weilenmann, D, Wöhrle, J, Cuculi, F, Leibundgut, G, Möbius-Winkler, S, Zweiker, R, Twerenbold, R, Kaiser, C, Jeger, R & BASKET-SMALL 2 Investigators 2020, 'Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial', CLIN RES CARDIOL, vol. 109, no. 9, pp. 1114-1124. https://doi.org/10.1007/s00392-020-01603-2

APA

Fahrni, G., Scheller, B., Coslovsky, M., Gilgen, N., Farah, A., Ohlow, M-A., Mangner, N., Weilenmann, D., Wöhrle, J., Cuculi, F., Leibundgut, G., Möbius-Winkler, S., Zweiker, R., Twerenbold, R., Kaiser, C., Jeger, R., & BASKET-SMALL 2 Investigators (2020). Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial. CLIN RES CARDIOL, 109(9), 1114-1124. https://doi.org/10.1007/s00392-020-01603-2

Vancouver

Fahrni G, Scheller B, Coslovsky M, Gilgen N, Farah A, Ohlow M-A et al. Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial. CLIN RES CARDIOL. 2020 Sep;109(9):1114-1124. https://doi.org/10.1007/s00392-020-01603-2

Bibtex

@article{30e291d32b554261a1ccf62bba068055,
title = "Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial",
abstract = "BACKGROUND: The randomized BASKET-SMALL 2 trial showed non-inferiority for treatment with drug-coated balloon (DCB) compared with drug-eluting stents (DES) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions in small coronary arteries regarding clinical endpoints at 1 year. In this predefined substudy, we investigated the angiographic findings in patients undergoing a clinically indicated follow-up angiography during the study phase.METHODS: Eight-hundred and eighty-three patients underwent PCI with either DES or DCB in a culprit vessel < 3 mm in diameter for stable coronary artery disease or acute coronary syndrome. Event-driven re-angiographies and the corresponding images at baseline were analyzed for angiographic endpoints.RESULTS: One-hundred and eleven patients (117 lesions, 66 DES versus 51 DCB) presented for an unscheduled re-angiography at median 5.7 months after the index procedure. At baseline, mean reference vessel diameter was 2.05 mm and the residual in-segment stenosis after the index procedure was less in DES compared to DCB (23.7% vs 33.8%, p = 0.001). At follow-up angiography, diameter stenosis in the DES group (29.0%) was still somewhat smaller than after DCB angioplasty (35.8%) when adjusting for time since PCI (p = 0.047), whereas lumen loss (LL) did not differ between the two treatment arms (LL-DES 0.06 mm vs LL-DCB 0.10 mm, p = 0.20). Eight patients following DES implantation presented with a complete occlusion of the target lesion compared to no occlusion in the DCB group (p = 0.009).CONCLUSIONS: The clinically indicated follow-up angiography within 1 year showed no difference in LL. Complete thrombotic vessel occlusions were found only in the DES group.CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov ; number, NCT01574534.",
keywords = "Aged, Angioplasty, Balloon, Coronary/methods, Coronary Angiography, Coronary Artery Disease/diagnostic imaging, Drug-Eluting Stents, Female, Follow-Up Studies, Humans, Male, Middle Aged, Percutaneous Coronary Intervention/methods, Treatment Outcome",
author = "Gregor Fahrni and Bruno Scheller and Michael Coslovsky and Nicole Gilgen and Ahmed Farah and Marc-Alexander Ohlow and Norman Mangner and Daniel Weilenmann and Jochen W{\"o}hrle and Florim Cuculi and Gregor Leibundgut and Sven M{\"o}bius-Winkler and Robert Zweiker and Raphael Twerenbold and Christoph Kaiser and Raban Jeger and {BASKET-SMALL 2 Investigators}",
year = "2020",
month = sep,
doi = "10.1007/s00392-020-01603-2",
language = "English",
volume = "109",
pages = "1114--1124",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "9",

}

RIS

TY - JOUR

T1 - Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial

AU - Fahrni, Gregor

AU - Scheller, Bruno

AU - Coslovsky, Michael

AU - Gilgen, Nicole

AU - Farah, Ahmed

AU - Ohlow, Marc-Alexander

AU - Mangner, Norman

AU - Weilenmann, Daniel

AU - Wöhrle, Jochen

AU - Cuculi, Florim

AU - Leibundgut, Gregor

AU - Möbius-Winkler, Sven

AU - Zweiker, Robert

AU - Twerenbold, Raphael

AU - Kaiser, Christoph

AU - Jeger, Raban

AU - BASKET-SMALL 2 Investigators

PY - 2020/9

Y1 - 2020/9

N2 - BACKGROUND: The randomized BASKET-SMALL 2 trial showed non-inferiority for treatment with drug-coated balloon (DCB) compared with drug-eluting stents (DES) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions in small coronary arteries regarding clinical endpoints at 1 year. In this predefined substudy, we investigated the angiographic findings in patients undergoing a clinically indicated follow-up angiography during the study phase.METHODS: Eight-hundred and eighty-three patients underwent PCI with either DES or DCB in a culprit vessel < 3 mm in diameter for stable coronary artery disease or acute coronary syndrome. Event-driven re-angiographies and the corresponding images at baseline were analyzed for angiographic endpoints.RESULTS: One-hundred and eleven patients (117 lesions, 66 DES versus 51 DCB) presented for an unscheduled re-angiography at median 5.7 months after the index procedure. At baseline, mean reference vessel diameter was 2.05 mm and the residual in-segment stenosis after the index procedure was less in DES compared to DCB (23.7% vs 33.8%, p = 0.001). At follow-up angiography, diameter stenosis in the DES group (29.0%) was still somewhat smaller than after DCB angioplasty (35.8%) when adjusting for time since PCI (p = 0.047), whereas lumen loss (LL) did not differ between the two treatment arms (LL-DES 0.06 mm vs LL-DCB 0.10 mm, p = 0.20). Eight patients following DES implantation presented with a complete occlusion of the target lesion compared to no occlusion in the DCB group (p = 0.009).CONCLUSIONS: The clinically indicated follow-up angiography within 1 year showed no difference in LL. Complete thrombotic vessel occlusions were found only in the DES group.CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov ; number, NCT01574534.

AB - BACKGROUND: The randomized BASKET-SMALL 2 trial showed non-inferiority for treatment with drug-coated balloon (DCB) compared with drug-eluting stents (DES) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions in small coronary arteries regarding clinical endpoints at 1 year. In this predefined substudy, we investigated the angiographic findings in patients undergoing a clinically indicated follow-up angiography during the study phase.METHODS: Eight-hundred and eighty-three patients underwent PCI with either DES or DCB in a culprit vessel < 3 mm in diameter for stable coronary artery disease or acute coronary syndrome. Event-driven re-angiographies and the corresponding images at baseline were analyzed for angiographic endpoints.RESULTS: One-hundred and eleven patients (117 lesions, 66 DES versus 51 DCB) presented for an unscheduled re-angiography at median 5.7 months after the index procedure. At baseline, mean reference vessel diameter was 2.05 mm and the residual in-segment stenosis after the index procedure was less in DES compared to DCB (23.7% vs 33.8%, p = 0.001). At follow-up angiography, diameter stenosis in the DES group (29.0%) was still somewhat smaller than after DCB angioplasty (35.8%) when adjusting for time since PCI (p = 0.047), whereas lumen loss (LL) did not differ between the two treatment arms (LL-DES 0.06 mm vs LL-DCB 0.10 mm, p = 0.20). Eight patients following DES implantation presented with a complete occlusion of the target lesion compared to no occlusion in the DCB group (p = 0.009).CONCLUSIONS: The clinically indicated follow-up angiography within 1 year showed no difference in LL. Complete thrombotic vessel occlusions were found only in the DES group.CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov ; number, NCT01574534.

KW - Aged

KW - Angioplasty, Balloon, Coronary/methods

KW - Coronary Angiography

KW - Coronary Artery Disease/diagnostic imaging

KW - Drug-Eluting Stents

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Percutaneous Coronary Intervention/methods

KW - Treatment Outcome

U2 - 10.1007/s00392-020-01603-2

DO - 10.1007/s00392-020-01603-2

M3 - SCORING: Journal article

C2 - 31993736

VL - 109

SP - 1114

EP - 1124

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 9

ER -