Drug safety and efficacy evaluation of sertindole for schizophrenia.
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Drug safety and efficacy evaluation of sertindole for schizophrenia. / Karamatskos, Evangelos; Lambert, Martin; Mulert, Christoph; Naber, Dieter.
In: EXPERT OPIN DRUG SAF, Vol. 11, No. 6, 6, 2012, p. 1047-1062.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Drug safety and efficacy evaluation of sertindole for schizophrenia.
AU - Karamatskos, Evangelos
AU - Lambert, Martin
AU - Mulert, Christoph
AU - Naber, Dieter
PY - 2012
Y1 - 2012
N2 - Despite the progress in antipsychotic treatment, modern antipsychotic medication is still associated with side effects, reduced compliance, drug discontinuation and insufficient effects on negative and cognitive symptoms. Sertindole is an antipsychotic compound, with high affinity for dopamine D(2), serotonin 5-HT(2A), 5-HT(2C) and ?(1)-adrenergic receptors, which has been reintroduced in the market after extended re-evaluation of its safety and risk-benefit profile.
AB - Despite the progress in antipsychotic treatment, modern antipsychotic medication is still associated with side effects, reduced compliance, drug discontinuation and insufficient effects on negative and cognitive symptoms. Sertindole is an antipsychotic compound, with high affinity for dopamine D(2), serotonin 5-HT(2A), 5-HT(2C) and ?(1)-adrenergic receptors, which has been reintroduced in the market after extended re-evaluation of its safety and risk-benefit profile.
KW - Animals
KW - Humans
KW - Risk Factors
KW - Randomized Controlled Trials as Topic
KW - Electrocardiography
KW - Dose-Response Relationship, Drug
KW - Schizophrenia/drug therapy/physiopathology
KW - Antipsychotic Agents/adverse effects/pharmacology/therapeutic use
KW - Cardiovascular Diseases/chemically induced/prevention & control
KW - Imidazoles/adverse effects/pharmacology/therapeutic use
KW - Indoles/adverse effects/pharmacology/therapeutic use
KW - Animals
KW - Humans
KW - Risk Factors
KW - Randomized Controlled Trials as Topic
KW - Electrocardiography
KW - Dose-Response Relationship, Drug
KW - Schizophrenia/drug therapy/physiopathology
KW - Antipsychotic Agents/adverse effects/pharmacology/therapeutic use
KW - Cardiovascular Diseases/chemically induced/prevention & control
KW - Imidazoles/adverse effects/pharmacology/therapeutic use
KW - Indoles/adverse effects/pharmacology/therapeutic use
M3 - SCORING: Journal article
VL - 11
SP - 1047
EP - 1062
JO - EXPERT OPIN DRUG SAF
JF - EXPERT OPIN DRUG SAF
SN - 1474-0338
IS - 6
M1 - 6
ER -
