Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization.
Standard
Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. / Soba, Peter; Zhu, Sijun; Emoto, Kazuo; Younger, Susan; Yang, Shun-Jen; Yu, Hung-Hsiang; Lee, Tzumin; Jan, Lily Yeh; Jan, Yuh-Nung.
In: NEURON, Vol. 54, No. 3, 3, 2007, p. 403-416.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization.
AU - Soba, Peter
AU - Zhu, Sijun
AU - Emoto, Kazuo
AU - Younger, Susan
AU - Yang, Shun-Jen
AU - Yu, Hung-Hsiang
AU - Lee, Tzumin
AU - Jan, Lily Yeh
AU - Jan, Yuh-Nung
PY - 2007
Y1 - 2007
N2 - A neuron's dendrites typically do not cross one another. This intrinsic self-avoidance mechanism ensures unambiguous processing of sensory or synaptic inputs. Moreover, some neurons respect the territory of others of the same type, a phenomenon known as tiling. Different types of neurons, however, often have overlapping dendritic fields. We found that Down's syndrome Cell Adhesion Molecule (Dscam) is required for dendritic self-avoidance of all four classes of Drosophila dendritic arborization (da) neurons. However, neighboring mutant class IV da neurons still exhibited tiling, suggesting that self-avoidance and tiling differ in their recognition and repulsion mechanisms. Introducing 1 of the 38,016 Dscam isoforms to da neurons in Dscam mutants was sufficient to significantly restore self-avoidance. Remarkably, expression of a common Dscam isoform in da neurons of different classes prevented their dendrites from sharing the same territory, suggesting that coexistence of dendritic fields of different neuronal classes requires divergent expression of Dscam isoforms.
AB - A neuron's dendrites typically do not cross one another. This intrinsic self-avoidance mechanism ensures unambiguous processing of sensory or synaptic inputs. Moreover, some neurons respect the territory of others of the same type, a phenomenon known as tiling. Different types of neurons, however, often have overlapping dendritic fields. We found that Down's syndrome Cell Adhesion Molecule (Dscam) is required for dendritic self-avoidance of all four classes of Drosophila dendritic arborization (da) neurons. However, neighboring mutant class IV da neurons still exhibited tiling, suggesting that self-avoidance and tiling differ in their recognition and repulsion mechanisms. Introducing 1 of the 38,016 Dscam isoforms to da neurons in Dscam mutants was sufficient to significantly restore self-avoidance. Remarkably, expression of a common Dscam isoform in da neurons of different classes prevented their dendrites from sharing the same territory, suggesting that coexistence of dendritic fields of different neuronal classes requires divergent expression of Dscam isoforms.
KW - Animals
KW - Gene Expression Regulation, Developmental
KW - Animals, Genetically Modified
KW - Mutation/physiology
KW - Staining and Labeling
KW - Dendrites/physiology/ultrastructure
KW - Drosophila
KW - Embryo, Nonmammalian
KW - Sense Organs/cytology
KW - Cell Adhesion Molecules
KW - Cell Shape/physiology
KW - Drosophila Proteins/physiology
KW - Neurons, Afferent/classification/cytology/physiology
KW - Animals
KW - Gene Expression Regulation, Developmental
KW - Animals, Genetically Modified
KW - Mutation/physiology
KW - Staining and Labeling
KW - Dendrites/physiology/ultrastructure
KW - Drosophila
KW - Embryo, Nonmammalian
KW - Sense Organs/cytology
KW - Cell Adhesion Molecules
KW - Cell Shape/physiology
KW - Drosophila Proteins/physiology
KW - Neurons, Afferent/classification/cytology/physiology
M3 - SCORING: Journal article
VL - 54
SP - 403
EP - 416
JO - NEURON
JF - NEURON
SN - 0896-6273
IS - 3
M1 - 3
ER -
