Research ExplorerPublicationsDronedarone induces regression of coronary artery remodeling...

Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status

Standard

Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status. / Quintana-Villamandos, Begoña; Pazó-Sayós, Laia; Arribas, Silvia Magdalena; Rodríguez-Rodríguez, Pilar; Böger, Rainer H; Lüneburg, Nicole; Delgado-Baeza, Emilio; González, Maria Carmen.

In: HYPERTENS RES, Vol. 42, No. 10, 10.2019, p. 1485-1494.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Quintana-Villamandos, B, Pazó-Sayós, L, Arribas, SM, Rodríguez-Rodríguez, P, Böger, RH, Lüneburg, N, Delgado-Baeza, E & González, MC 2019, 'Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status', HYPERTENS RES, vol. 42, no. 10, pp. 1485-1494. https://doi.org/10.1038/s41440-019-0257-z

APA

Quintana-Villamandos, B., Pazó-Sayós, L., Arribas, S. M., Rodríguez-Rodríguez, P., Böger, R. H., Lüneburg, N., Delgado-Baeza, E., & González, M. C. (2019). Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status. HYPERTENS RES, 42(10), 1485-1494. https://doi.org/10.1038/s41440-019-0257-z

Vancouver

Quintana-Villamandos B, Pazó-Sayós L, Arribas SM, Rodríguez-Rodríguez P, Böger RH, Lüneburg N et al. Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status. HYPERTENS RES. 2019 Oct;42(10):1485-1494. https://doi.org/10.1038/s41440-019-0257-z

Bibtex

@article{9a0f91eba03942308c4e2a5c6a39bebf,
title = "Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status",
abstract = "Our group previously demonstrated that dronedarone induces regression of left ventricular hypertrophy in spontaneously hypertensive rats (SHRs). We assessed changes in vascular remodeling and oxidative stress following short-term use of this agent. The coronary artery was isolated from 10-month-old male SHRs treated with 100 mg kg-1 dronedarone once daily for 14 days (SHR-D group), and age-matched untreated SHRs were used as hypertensive controls. We analyzed the geometry and composition of the artery and constructed dose-response curves for acetylcholine and serotonin (5-HT). We calculated a global score (OXY-SCORE) from plasma biomarkers of oxidative status: carbonyl levels, thiol levels, reduced glutathione levels, total antioxidant capacity, and superoxide anion scavenging activity. Finally, we analyzed asymmetric dimethylarginine (ADMA) concentrations in plasma. Dronedarone significantly decreased wall thickness (medial and adventitial layer thickness and cell count) and the cross-sectional area of the artery. Dronedarone significantly improved endothelium-dependent relaxation and reduced the contraction induced by 5-HT. The OXY-SCORE was negative in the SHR model group (suggesting an enhanced oxidative status) and was positive in the SHR-D group (suggesting enhanced antioxidant defense). Dronedarone significantly decreased the concentrations of ADMA. We conclude that dronedarone improves coronary artery remodeling in SHRs. The better global antioxidant status after treatment with dronedarone and decreased plasma ADMA levels could contribute to the cardiovascular protective effect of dronedarone.",
keywords = "Animals, Antioxidants/metabolism, Arginine/analogs & derivatives, Coronary Vessels/drug effects, Dronedarone/pharmacology, Male, Nitric Oxide/physiology, Rats, Rats, Inbred SHR, Rats, Inbred WKY, Vascular Remodeling/drug effects, Vasoconstriction/drug effects",
author = "Bego{\~n}a Quintana-Villamandos and Laia Paz{\'o}-Say{\'o}s and Arribas, {Silvia Magdalena} and Pilar Rodr{\'i}guez-Rodr{\'i}guez and B{\"o}ger, {Rainer H} and Nicole L{\"u}neburg and Emilio Delgado-Baeza and Gonz{\'a}lez, {Maria Carmen}",
year = "2019",
month = oct,
doi = "10.1038/s41440-019-0257-z",
language = "English",
volume = "42",
pages = "1485--1494",
journal = "HYPERTENS RES",
issn = "0916-9636",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status

AU - Quintana-Villamandos, Begoña

AU - Pazó-Sayós, Laia

AU - Arribas, Silvia Magdalena

AU - Rodríguez-Rodríguez, Pilar

AU - Böger, Rainer H

AU - Lüneburg, Nicole

AU - Delgado-Baeza, Emilio

AU - González, Maria Carmen

PY - 2019/10

Y1 - 2019/10

N2 - Our group previously demonstrated that dronedarone induces regression of left ventricular hypertrophy in spontaneously hypertensive rats (SHRs). We assessed changes in vascular remodeling and oxidative stress following short-term use of this agent. The coronary artery was isolated from 10-month-old male SHRs treated with 100 mg kg-1 dronedarone once daily for 14 days (SHR-D group), and age-matched untreated SHRs were used as hypertensive controls. We analyzed the geometry and composition of the artery and constructed dose-response curves for acetylcholine and serotonin (5-HT). We calculated a global score (OXY-SCORE) from plasma biomarkers of oxidative status: carbonyl levels, thiol levels, reduced glutathione levels, total antioxidant capacity, and superoxide anion scavenging activity. Finally, we analyzed asymmetric dimethylarginine (ADMA) concentrations in plasma. Dronedarone significantly decreased wall thickness (medial and adventitial layer thickness and cell count) and the cross-sectional area of the artery. Dronedarone significantly improved endothelium-dependent relaxation and reduced the contraction induced by 5-HT. The OXY-SCORE was negative in the SHR model group (suggesting an enhanced oxidative status) and was positive in the SHR-D group (suggesting enhanced antioxidant defense). Dronedarone significantly decreased the concentrations of ADMA. We conclude that dronedarone improves coronary artery remodeling in SHRs. The better global antioxidant status after treatment with dronedarone and decreased plasma ADMA levels could contribute to the cardiovascular protective effect of dronedarone.

AB - Our group previously demonstrated that dronedarone induces regression of left ventricular hypertrophy in spontaneously hypertensive rats (SHRs). We assessed changes in vascular remodeling and oxidative stress following short-term use of this agent. The coronary artery was isolated from 10-month-old male SHRs treated with 100 mg kg-1 dronedarone once daily for 14 days (SHR-D group), and age-matched untreated SHRs were used as hypertensive controls. We analyzed the geometry and composition of the artery and constructed dose-response curves for acetylcholine and serotonin (5-HT). We calculated a global score (OXY-SCORE) from plasma biomarkers of oxidative status: carbonyl levels, thiol levels, reduced glutathione levels, total antioxidant capacity, and superoxide anion scavenging activity. Finally, we analyzed asymmetric dimethylarginine (ADMA) concentrations in plasma. Dronedarone significantly decreased wall thickness (medial and adventitial layer thickness and cell count) and the cross-sectional area of the artery. Dronedarone significantly improved endothelium-dependent relaxation and reduced the contraction induced by 5-HT. The OXY-SCORE was negative in the SHR model group (suggesting an enhanced oxidative status) and was positive in the SHR-D group (suggesting enhanced antioxidant defense). Dronedarone significantly decreased the concentrations of ADMA. We conclude that dronedarone improves coronary artery remodeling in SHRs. The better global antioxidant status after treatment with dronedarone and decreased plasma ADMA levels could contribute to the cardiovascular protective effect of dronedarone.

KW - Animals

KW - Antioxidants/metabolism

KW - Arginine/analogs & derivatives

KW - Coronary Vessels/drug effects

KW - Dronedarone/pharmacology

KW - Male

KW - Nitric Oxide/physiology

KW - Rats

KW - Rats, Inbred SHR

KW - Rats, Inbred WKY

KW - Vascular Remodeling/drug effects

KW - Vasoconstriction/drug effects

U2 - 10.1038/s41440-019-0257-z

DO - 10.1038/s41440-019-0257-z

M3 - SCORING: Journal article

C2 - 30992541

VL - 42

SP - 1485

EP - 1494

JO - HYPERTENS RES

JF - HYPERTENS RES

SN - 0916-9636

IS - 10

ER -