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DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance

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DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance. / Nymberg, Charlotte; Banaschewski, Tobias; Bokde, Arun Lw; Büchel, Christian; Conrod, Patricia; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, P; Heinz, Andreas; Ittermann, Bernd; Mann, Karl; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomas; Pausova, Zdenka; Rietschel, Marcella; Robbins, Trevor W; Smolka, Michael N; Ströhle, Andreas; Schumann, Gunter; Klingberg, Torkel; IMAGEN Consortium.

In: NEUROPSYCHOPHARMACOL, Vol. 39, No. 10, 2014, p. 2357-2365.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nymberg, C, Banaschewski, T, Bokde, AL, Büchel, C, Conrod, P, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Mann, K, Martinot, J-L, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Robbins, TW, Smolka, MN, Ströhle, A, Schumann, G, Klingberg, T & IMAGEN Consortium 2014, 'DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance', NEUROPSYCHOPHARMACOL, vol. 39, no. 10, pp. 2357-2365. https://doi.org/10.1038/npp.2014.83

APA

Nymberg, C., Banaschewski, T., Bokde, A. L., Büchel, C., Conrod, P., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Mann, K., Martinot, J-L., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Robbins, T. W., Smolka, M. N., ... IMAGEN Consortium (2014). DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance. NEUROPSYCHOPHARMACOL, 39(10), 2357-2365. https://doi.org/10.1038/npp.2014.83

Vancouver

Nymberg C, Banaschewski T, Bokde AL, Büchel C, Conrod P, Flor H et al. DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance. NEUROPSYCHOPHARMACOL. 2014;39(10):2357-2365. https://doi.org/10.1038/npp.2014.83

Bibtex

@article{d67f4e1dbdf14ac3aa14212e857d0e0f,
title = "DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance",
abstract = "Motivation is important for learning and cognition. Although dopaminergic (D2) transmission in the ventral striatum (VS) is associated with motivation, learning, and cognition are more strongly associated with function of the dorsal striatum, including activation in the caudate nucleus. A recent study found an interaction between intrinsic motivation and the DRD2/ANKK1 polymorphism (rs1800497), suggesting that A-carriers of rs1800497 are significantly more sensitive to motivation in order to improve during working memory (WM) training. Using data from the two large-scale imaging genetic data sets, IMAGEN (n=1080, age 13-15 years) and BrainChild (n∼300, age 6-27), we investigated whether rs1800497 is associated with WM. In the IMAGEN data set, we tested whether VS/caudate activation during reward anticipation was associated with WM performance and whether rs1800497 and VS/caudate activation interact to affect WM performance. We found that rs1800497 was associated with WM performance in IMAGEN and BrainChild. Higher VS and caudate activation during reward processing were significantly associated with higher WM performance (p<0.0001). An interaction was found between the DRD2/ANKK1 polymorphism rs1800497 and VS activation during reward anticipation on WM (p<0.01), such that carriers of the minor allele (A) showed a significant correlation between VS activation and WM, whereas the GG-homozygotes did not, suggesting that the effect of VS BOLD on WM is modified by inter-individual genetic differences related to D2 dopaminergic transmission.Neuropsychopharmacology advance online publication, 14 May 2014; doi:10.1038/npp.2014.83.",
author = "Charlotte Nymberg and Tobias Banaschewski and Bokde, {Arun Lw} and Christian B{\"u}chel and Patricia Conrod and Herta Flor and Vincent Frouin and Hugh Garavan and P Gowland and Andreas Heinz and Bernd Ittermann and Karl Mann and Jean-Luc Martinot and Frauke Nees and Tomas Paus and Zdenka Pausova and Marcella Rietschel and Robbins, {Trevor W} and Smolka, {Michael N} and Andreas Str{\"o}hle and Gunter Schumann and Torkel Klingberg and {IMAGEN Consortium} and J{\"u}rgen Finsterbusch",
year = "2014",
doi = "10.1038/npp.2014.83",
language = "English",
volume = "39",
pages = "2357--2365",
journal = "NEUROPSYCHOPHARMACOL",
issn = "0893-133X",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance

AU - Nymberg, Charlotte

AU - Banaschewski, Tobias

AU - Bokde, Arun Lw

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, P

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Mann, Karl

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Rietschel, Marcella

AU - Robbins, Trevor W

AU - Smolka, Michael N

AU - Ströhle, Andreas

AU - Schumann, Gunter

AU - Klingberg, Torkel

AU - IMAGEN Consortium

AU - Finsterbusch, Jürgen

PY - 2014

Y1 - 2014

N2 - Motivation is important for learning and cognition. Although dopaminergic (D2) transmission in the ventral striatum (VS) is associated with motivation, learning, and cognition are more strongly associated with function of the dorsal striatum, including activation in the caudate nucleus. A recent study found an interaction between intrinsic motivation and the DRD2/ANKK1 polymorphism (rs1800497), suggesting that A-carriers of rs1800497 are significantly more sensitive to motivation in order to improve during working memory (WM) training. Using data from the two large-scale imaging genetic data sets, IMAGEN (n=1080, age 13-15 years) and BrainChild (n∼300, age 6-27), we investigated whether rs1800497 is associated with WM. In the IMAGEN data set, we tested whether VS/caudate activation during reward anticipation was associated with WM performance and whether rs1800497 and VS/caudate activation interact to affect WM performance. We found that rs1800497 was associated with WM performance in IMAGEN and BrainChild. Higher VS and caudate activation during reward processing were significantly associated with higher WM performance (p<0.0001). An interaction was found between the DRD2/ANKK1 polymorphism rs1800497 and VS activation during reward anticipation on WM (p<0.01), such that carriers of the minor allele (A) showed a significant correlation between VS activation and WM, whereas the GG-homozygotes did not, suggesting that the effect of VS BOLD on WM is modified by inter-individual genetic differences related to D2 dopaminergic transmission.Neuropsychopharmacology advance online publication, 14 May 2014; doi:10.1038/npp.2014.83.

AB - Motivation is important for learning and cognition. Although dopaminergic (D2) transmission in the ventral striatum (VS) is associated with motivation, learning, and cognition are more strongly associated with function of the dorsal striatum, including activation in the caudate nucleus. A recent study found an interaction between intrinsic motivation and the DRD2/ANKK1 polymorphism (rs1800497), suggesting that A-carriers of rs1800497 are significantly more sensitive to motivation in order to improve during working memory (WM) training. Using data from the two large-scale imaging genetic data sets, IMAGEN (n=1080, age 13-15 years) and BrainChild (n∼300, age 6-27), we investigated whether rs1800497 is associated with WM. In the IMAGEN data set, we tested whether VS/caudate activation during reward anticipation was associated with WM performance and whether rs1800497 and VS/caudate activation interact to affect WM performance. We found that rs1800497 was associated with WM performance in IMAGEN and BrainChild. Higher VS and caudate activation during reward processing were significantly associated with higher WM performance (p<0.0001). An interaction was found between the DRD2/ANKK1 polymorphism rs1800497 and VS activation during reward anticipation on WM (p<0.01), such that carriers of the minor allele (A) showed a significant correlation between VS activation and WM, whereas the GG-homozygotes did not, suggesting that the effect of VS BOLD on WM is modified by inter-individual genetic differences related to D2 dopaminergic transmission.Neuropsychopharmacology advance online publication, 14 May 2014; doi:10.1038/npp.2014.83.

U2 - 10.1038/npp.2014.83

DO - 10.1038/npp.2014.83

M3 - SCORING: Journal article

C2 - 24713612

VL - 39

SP - 2357

EP - 2365

JO - NEUROPSYCHOPHARMACOL

JF - NEUROPSYCHOPHARMACOL

SN - 0893-133X

IS - 10

ER -