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Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies

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Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies. / Manolakou, Theodora; Kaltezioti, Valeria; Prakoura, Niki; Kavvadas, Panagiotis; Reichelt-Wurm, Simone; Gakiopoulou, Harikleia; Banas, Miriam; Banas, Bernhard; Lindenmeyer, Maja T; Cohen, Clemens D; Boor, Peter; Djudjaj, Sonja; Boumpas, Dimitrios T; Chatziantoniou, Christos; Charonis, Aristidis; Politis, Panagiotis K.

In: J CELL MOL MED, Vol. 27, No. 9, 05.2023, p. 1192-1205.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Manolakou, T, Kaltezioti, V, Prakoura, N, Kavvadas, P, Reichelt-Wurm, S, Gakiopoulou, H, Banas, M, Banas, B, Lindenmeyer, MT, Cohen, CD, Boor, P, Djudjaj, S, Boumpas, DT, Chatziantoniou, C, Charonis, A & Politis, PK 2023, 'Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies', J CELL MOL MED, vol. 27, no. 9, pp. 1192-1205. https://doi.org/10.1111/jcmm.17014

APA

Manolakou, T., Kaltezioti, V., Prakoura, N., Kavvadas, P., Reichelt-Wurm, S., Gakiopoulou, H., Banas, M., Banas, B., Lindenmeyer, M. T., Cohen, C. D., Boor, P., Djudjaj, S., Boumpas, D. T., Chatziantoniou, C., Charonis, A., & Politis, P. K. (2023). Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies. J CELL MOL MED, 27(9), 1192-1205. https://doi.org/10.1111/jcmm.17014

Vancouver

Manolakou T, Kaltezioti V, Prakoura N, Kavvadas P, Reichelt-Wurm S, Gakiopoulou H et al. Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies. J CELL MOL MED. 2023 May;27(9):1192-1205. https://doi.org/10.1111/jcmm.17014

Bibtex

@article{3e588481bcda40bfa0a29be4e26b3816,
title = "Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies",
abstract = "Chronic kidney diseases affect a substantial percentage of the adult population worldwide. This observation emphasizes the need for novel insights into the molecular mechanisms that control the onset and progression of renal diseases. Recent advances in genomics have uncovered a previously unanticipated link between the non-coding genome and human kidney diseases. Here we screened and analysed long non-coding RNAs (lncRNAs) previously identified in mouse kidneys by genome-wide transcriptomic analysis, for conservation in humans and differential expression in renal tissue from healthy and diseased individuals. Our data suggest that LINC01187 is strongly down-regulated in human kidney tissues of patients with diabetic nephropathy and rapidly progressive glomerulonephritis, as well as in murine models of kidney diseases, including unilateral ureteral obstruction, nephrotoxic serum-induced glomerulonephritis and ischemia/reperfusion. Interestingly, LINC01187 overexpression in human kidney cells in vitro inhibits cell death indicating an anti-apoptotic function. Collectively, these data suggest a negative association of LINC01187 expression with renal diseases implying a potential protective role.",
keywords = "Animals, Humans, Mice, Diabetic Nephropathies/metabolism, Down-Regulation/genetics, Glomerulonephritis/metabolism, Kidney/metabolism, RNA, Long Noncoding/metabolism",
author = "Theodora Manolakou and Valeria Kaltezioti and Niki Prakoura and Panagiotis Kavvadas and Simone Reichelt-Wurm and Harikleia Gakiopoulou and Miriam Banas and Bernhard Banas and Lindenmeyer, {Maja T} and Cohen, {Clemens D} and Peter Boor and Sonja Djudjaj and Boumpas, {Dimitrios T} and Christos Chatziantoniou and Aristidis Charonis and Politis, {Panagiotis K}",
note = "{\textcopyright} 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.",
year = "2023",
month = may,
doi = "10.1111/jcmm.17014",
language = "English",
volume = "27",
pages = "1192--1205",
journal = "J CELL MOL MED",
issn = "1582-1838",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies

AU - Manolakou, Theodora

AU - Kaltezioti, Valeria

AU - Prakoura, Niki

AU - Kavvadas, Panagiotis

AU - Reichelt-Wurm, Simone

AU - Gakiopoulou, Harikleia

AU - Banas, Miriam

AU - Banas, Bernhard

AU - Lindenmeyer, Maja T

AU - Cohen, Clemens D

AU - Boor, Peter

AU - Djudjaj, Sonja

AU - Boumpas, Dimitrios T

AU - Chatziantoniou, Christos

AU - Charonis, Aristidis

AU - Politis, Panagiotis K

N1 - © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

PY - 2023/5

Y1 - 2023/5

N2 - Chronic kidney diseases affect a substantial percentage of the adult population worldwide. This observation emphasizes the need for novel insights into the molecular mechanisms that control the onset and progression of renal diseases. Recent advances in genomics have uncovered a previously unanticipated link between the non-coding genome and human kidney diseases. Here we screened and analysed long non-coding RNAs (lncRNAs) previously identified in mouse kidneys by genome-wide transcriptomic analysis, for conservation in humans and differential expression in renal tissue from healthy and diseased individuals. Our data suggest that LINC01187 is strongly down-regulated in human kidney tissues of patients with diabetic nephropathy and rapidly progressive glomerulonephritis, as well as in murine models of kidney diseases, including unilateral ureteral obstruction, nephrotoxic serum-induced glomerulonephritis and ischemia/reperfusion. Interestingly, LINC01187 overexpression in human kidney cells in vitro inhibits cell death indicating an anti-apoptotic function. Collectively, these data suggest a negative association of LINC01187 expression with renal diseases implying a potential protective role.

AB - Chronic kidney diseases affect a substantial percentage of the adult population worldwide. This observation emphasizes the need for novel insights into the molecular mechanisms that control the onset and progression of renal diseases. Recent advances in genomics have uncovered a previously unanticipated link between the non-coding genome and human kidney diseases. Here we screened and analysed long non-coding RNAs (lncRNAs) previously identified in mouse kidneys by genome-wide transcriptomic analysis, for conservation in humans and differential expression in renal tissue from healthy and diseased individuals. Our data suggest that LINC01187 is strongly down-regulated in human kidney tissues of patients with diabetic nephropathy and rapidly progressive glomerulonephritis, as well as in murine models of kidney diseases, including unilateral ureteral obstruction, nephrotoxic serum-induced glomerulonephritis and ischemia/reperfusion. Interestingly, LINC01187 overexpression in human kidney cells in vitro inhibits cell death indicating an anti-apoptotic function. Collectively, these data suggest a negative association of LINC01187 expression with renal diseases implying a potential protective role.

KW - Animals

KW - Humans

KW - Mice

KW - Diabetic Nephropathies/metabolism

KW - Down-Regulation/genetics

KW - Glomerulonephritis/metabolism

KW - Kidney/metabolism

KW - RNA, Long Noncoding/metabolism

U2 - 10.1111/jcmm.17014

DO - 10.1111/jcmm.17014

M3 - SCORING: Journal article

C2 - 37056054

VL - 27

SP - 1192

EP - 1205

JO - J CELL MOL MED

JF - J CELL MOL MED

SN - 1582-1838

IS - 9

ER -