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Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study

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Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study. / Wagenfeld, Lars; Schwarzer, Hendrik; Roessler, Gernot; Klemm, Maren; Skevas, Christos; Richard, Gisbert; Zeitz, Oliver.

In: BIOMED RES INT , Vol. 2014, 2014, p. 983102.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wagenfeld, L, Schwarzer, H, Roessler, G, Klemm, M, Skevas, C, Richard, G & Zeitz, O 2014, 'Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study', BIOMED RES INT , vol. 2014, pp. 983102. https://doi.org/10.1155/2014/983102

APA

Wagenfeld, L., Schwarzer, H., Roessler, G., Klemm, M., Skevas, C., Richard, G., & Zeitz, O. (2014). Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study. BIOMED RES INT , 2014, 983102. https://doi.org/10.1155/2014/983102

Vancouver

Wagenfeld L, Schwarzer H, Roessler G, Klemm M, Skevas C, Richard G et al. Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study. BIOMED RES INT . 2014;2014:983102. https://doi.org/10.1155/2014/983102

Bibtex

@article{42130d3aaadd42b99f1e3ff81526ecce,
title = "Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study",
abstract = "PURPOSE: The relationship between number of laser burns of cyclophotocoagulation (CPC) and intraocular pressure (IOP) reduction is unknown. This animal model was established to reveal a possible dose-response-relationship between the number of applied laser burns and the IOP lowering effect.METHODS: 30 chinchilla bastard rabbits were divided into 5 groups and treated with either 1, 5, 10, 20, or 30 CPC burns, respectively. IOP was followed up for 1 week. IOP reduction of a single 30-burn treatment was compared with a fractionated treatment (three sessions; one week in between; 10 burns/session).RESULTS: IOP reduction increases nonlinearly with the number of CPC burns (max. -6.1 ± 1.4 mmHg). Fractionated treatment shows similar IOP reduction with less complications and more constant results compared to single session treatment.CONCLUSIONS: The study reveals a complex relationship between IOP reduction and the number of CPC burns. Fractionated CPC gives comparable IOP reduction at a higher degree of safety.",
author = "Lars Wagenfeld and Hendrik Schwarzer and Gernot Roessler and Maren Klemm and Christos Skevas and Gisbert Richard and Oliver Zeitz",
year = "2014",
doi = "10.1155/2014/983102",
language = "English",
volume = "2014",
pages = "983102",
journal = "BIOMED RES INT ",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study

AU - Wagenfeld, Lars

AU - Schwarzer, Hendrik

AU - Roessler, Gernot

AU - Klemm, Maren

AU - Skevas, Christos

AU - Richard, Gisbert

AU - Zeitz, Oliver

PY - 2014

Y1 - 2014

N2 - PURPOSE: The relationship between number of laser burns of cyclophotocoagulation (CPC) and intraocular pressure (IOP) reduction is unknown. This animal model was established to reveal a possible dose-response-relationship between the number of applied laser burns and the IOP lowering effect.METHODS: 30 chinchilla bastard rabbits were divided into 5 groups and treated with either 1, 5, 10, 20, or 30 CPC burns, respectively. IOP was followed up for 1 week. IOP reduction of a single 30-burn treatment was compared with a fractionated treatment (three sessions; one week in between; 10 burns/session).RESULTS: IOP reduction increases nonlinearly with the number of CPC burns (max. -6.1 ± 1.4 mmHg). Fractionated treatment shows similar IOP reduction with less complications and more constant results compared to single session treatment.CONCLUSIONS: The study reveals a complex relationship between IOP reduction and the number of CPC burns. Fractionated CPC gives comparable IOP reduction at a higher degree of safety.

AB - PURPOSE: The relationship between number of laser burns of cyclophotocoagulation (CPC) and intraocular pressure (IOP) reduction is unknown. This animal model was established to reveal a possible dose-response-relationship between the number of applied laser burns and the IOP lowering effect.METHODS: 30 chinchilla bastard rabbits were divided into 5 groups and treated with either 1, 5, 10, 20, or 30 CPC burns, respectively. IOP was followed up for 1 week. IOP reduction of a single 30-burn treatment was compared with a fractionated treatment (three sessions; one week in between; 10 burns/session).RESULTS: IOP reduction increases nonlinearly with the number of CPC burns (max. -6.1 ± 1.4 mmHg). Fractionated treatment shows similar IOP reduction with less complications and more constant results compared to single session treatment.CONCLUSIONS: The study reveals a complex relationship between IOP reduction and the number of CPC burns. Fractionated CPC gives comparable IOP reduction at a higher degree of safety.

U2 - 10.1155/2014/983102

DO - 10.1155/2014/983102

M3 - SCORING: Journal article

C2 - 25054158

VL - 2014

SP - 983102

JO - BIOMED RES INT

JF - BIOMED RES INT

SN - 2314-6133

ER -