Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia.
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Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia. / Hessling, Jörg; Kröger, Nicolaus-Martin; Werner, Mathias; Zabelina, Tatjana; Hansen, Arne; Kordes, Uwe; Ayuketang Ayuk, Francis; Renges, Helmut-Hans; Panse, Jens; Erttmann, Rudolf; Zander, Axel.
In: BRIT J HAEMATOL, Vol. 119, No. 3, 3, 2002, p. 769-772.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia.
AU - Hessling, Jörg
AU - Kröger, Nicolaus-Martin
AU - Werner, Mathias
AU - Zabelina, Tatjana
AU - Hansen, Arne
AU - Kordes, Uwe
AU - Ayuketang Ayuk, Francis
AU - Renges, Helmut-Hans
AU - Panse, Jens
AU - Erttmann, Rudolf
AU - Zander, Axel
PY - 2002
Y1 - 2002
N2 - Three patients with myelofibrosis received allogeneic stem cell transplantation after a dose-reduced conditioning regimen of busulphan (8 mg/kg), fludarabine (180 mg/m2) and antithymocyte globulin (4 x 10 mg/kg). The median age at transplantation was 51 years (range 44-58). All patients engrafted with a leucocyte count > 1.0 x 10(9)/l after a median of 18 d (range 16-20). Grade II acute skin graft-versus-host disease (GvHD) occurred in one patient. One limited and one extensive chronic GvHD was observed. All patients achieved complete haematological remission. In one patient the fibrosis resolved completely 180 d post transplant. All patients are alive 126, 466 and 764 d after transplantation.
AB - Three patients with myelofibrosis received allogeneic stem cell transplantation after a dose-reduced conditioning regimen of busulphan (8 mg/kg), fludarabine (180 mg/m2) and antithymocyte globulin (4 x 10 mg/kg). The median age at transplantation was 51 years (range 44-58). All patients engrafted with a leucocyte count > 1.0 x 10(9)/l after a median of 18 d (range 16-20). Grade II acute skin graft-versus-host disease (GvHD) occurred in one patient. One limited and one extensive chronic GvHD was observed. All patients achieved complete haematological remission. In one patient the fibrosis resolved completely 180 d post transplant. All patients are alive 126, 466 and 764 d after transplantation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 119
SP - 769
EP - 772
JO - BRIT J HAEMATOL
JF - BRIT J HAEMATOL
SN - 0007-1048
IS - 3
M1 - 3
ER -