Dorsolateral prefrontal cortex modulates striatal reward encoding during reappraisal of reward anticipation.
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Dorsolateral prefrontal cortex modulates striatal reward encoding during reappraisal of reward anticipation. / Staudinger, Markus; Erk, Susanne; Walter, Henrik.
In: CEREB CORTEX, Vol. 21, No. 11, 11, 2011, p. 2578-2588.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dorsolateral prefrontal cortex modulates striatal reward encoding during reappraisal of reward anticipation.
AU - Staudinger, Markus
AU - Erk, Susanne
AU - Walter, Henrik
PY - 2011
Y1 - 2011
N2 - Recent research showed that cognitive emotion regulation (ER) both increases activity in the dorsolateral prefrontal cortex (DLPFC) and decreases striatal responsivity to monetary rewards. Using a mixed monetary incentive delay/memory task as well as functional magnetic resonance imaging, we tested in healthy subjects whether ER effectively attenuates striatal reward encoding during the anticipation of reward (€1.00 vs. €0.05 reward cues) as well as subsequent target reaction times (RTs), which are an indicator of motivation to obtain reward. ER significantly diminished feelings of pleasant anticipation and slowed down €1.00 target RT. At the neural level, ER increased activity in the DLPFC and attenuated reward encoding in the left putamen. Analyses of psychophysiological interaction revealed that DLPFC activity correlated more positively with putamen activity during €0.05 than during €1.00 reward trials. Furthermore, parametric modulations showed that anticipatory left putamen activity correlated with target RT during nonregulation. No such correlation could be observed during ER, suggesting that ER had abolished preparatory target RT encoding. Our results provide evidence that ER can attenuate behavioral and striatal measures of reward-related motivation and motor preparation. Furthermore, the present findings suggest that the DLPFC might contribute to successful regulation of reward via increased promotion of low-reward responses.
AB - Recent research showed that cognitive emotion regulation (ER) both increases activity in the dorsolateral prefrontal cortex (DLPFC) and decreases striatal responsivity to monetary rewards. Using a mixed monetary incentive delay/memory task as well as functional magnetic resonance imaging, we tested in healthy subjects whether ER effectively attenuates striatal reward encoding during the anticipation of reward (€1.00 vs. €0.05 reward cues) as well as subsequent target reaction times (RTs), which are an indicator of motivation to obtain reward. ER significantly diminished feelings of pleasant anticipation and slowed down €1.00 target RT. At the neural level, ER increased activity in the DLPFC and attenuated reward encoding in the left putamen. Analyses of psychophysiological interaction revealed that DLPFC activity correlated more positively with putamen activity during €0.05 than during €1.00 reward trials. Furthermore, parametric modulations showed that anticipatory left putamen activity correlated with target RT during nonregulation. No such correlation could be observed during ER, suggesting that ER had abolished preparatory target RT encoding. Our results provide evidence that ER can attenuate behavioral and striatal measures of reward-related motivation and motor preparation. Furthermore, the present findings suggest that the DLPFC might contribute to successful regulation of reward via increased promotion of low-reward responses.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Magnetic Resonance Imaging
KW - Brain Mapping
KW - Reward
KW - Cues
KW - Emotions/physiology
KW - Prefrontal Cortex/physiology
KW - Corpus Striatum/physiology
KW - Motivation/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Magnetic Resonance Imaging
KW - Brain Mapping
KW - Reward
KW - Cues
KW - Emotions/physiology
KW - Prefrontal Cortex/physiology
KW - Corpus Striatum/physiology
KW - Motivation/physiology
M3 - SCORING: Journal article
VL - 21
SP - 2578
EP - 2588
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 11
M1 - 11
ER -