Dopaminergic stimulation facilitates working memory and differentially affects prefrontal low theta oscillations
Standard
Dopaminergic stimulation facilitates working memory and differentially affects prefrontal low theta oscillations. / Eckart, Cindy; Fuentemilla, Lluís; Bauch, Eva M; Bunzeck, Nico.
In: NEUROIMAGE, Vol. 94, 01.07.2014, p. 185-92.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Dopaminergic stimulation facilitates working memory and differentially affects prefrontal low theta oscillations
AU - Eckart, Cindy
AU - Fuentemilla, Lluís
AU - Bauch, Eva M
AU - Bunzeck, Nico
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - We used electroencephalography (EEG) together with psychopharmacological stimulation to investigate the role of dopamine in neural oscillations during working memory (WM). Following a within-subjects design, healthy humans either received the dopamine precursor L-Dopa (150 mg) or a placebo before they performed a Sternberg WM paradigm. Here, sequences of sample images had to be memorized for a delay of 5 s in three different load conditions (two, four or six items). On the next day, long-term memory (LTM) for the images was tested. Behaviorally, L-Dopa improved WM and LTM performance as a function of WM load. More precisely, there was a specific drug effect in the four-load condition with faster reaction times to the probe in the WM task and higher corrected hit-rates in the LTM task. During the maintenance period, there was a linear and quadratic effect of WM load on power in the high theta (5-8 Hz) and alpha (9-14 Hz) frequency range at frontal sensors. Importantly, a drug by load interaction--mimicking the behavioral results--was found only in low theta power (2-4 Hz). As such, our results indicate a specific link between prefrontal low theta oscillations, dopaminergic neuromodulation during WM and subsequent LTM performance.
AB - We used electroencephalography (EEG) together with psychopharmacological stimulation to investigate the role of dopamine in neural oscillations during working memory (WM). Following a within-subjects design, healthy humans either received the dopamine precursor L-Dopa (150 mg) or a placebo before they performed a Sternberg WM paradigm. Here, sequences of sample images had to be memorized for a delay of 5 s in three different load conditions (two, four or six items). On the next day, long-term memory (LTM) for the images was tested. Behaviorally, L-Dopa improved WM and LTM performance as a function of WM load. More precisely, there was a specific drug effect in the four-load condition with faster reaction times to the probe in the WM task and higher corrected hit-rates in the LTM task. During the maintenance period, there was a linear and quadratic effect of WM load on power in the high theta (5-8 Hz) and alpha (9-14 Hz) frequency range at frontal sensors. Importantly, a drug by load interaction--mimicking the behavioral results--was found only in low theta power (2-4 Hz). As such, our results indicate a specific link between prefrontal low theta oscillations, dopaminergic neuromodulation during WM and subsequent LTM performance.
KW - Adult
KW - Biological Clocks
KW - Brain Mapping
KW - Dopamine
KW - Dopamine Agents
KW - Dopaminergic Neurons
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Levodopa
KW - Long-Term Potentiation
KW - Male
KW - Memory, Short-Term
KW - Nerve Net
KW - Prefrontal Cortex
KW - Task Performance and Analysis
KW - Theta Rhythm
U2 - 10.1016/j.neuroimage.2014.03.011
DO - 10.1016/j.neuroimage.2014.03.011
M3 - SCORING: Journal article
C2 - 24642289
VL - 94
SP - 185
EP - 192
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
ER -