Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making
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Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making. / Chakroun, Karima; Mathar, David; Wiehler, Antonius; Ganzer, Florian; Peters, Jan.
In: ELIFE, Vol. 9, 02.06.2020, p. 1-44.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making
AU - Chakroun, Karima
AU - Mathar, David
AU - Wiehler, Antonius
AU - Ganzer, Florian
AU - Peters, Jan
N1 - © 2020, Chakroun et al.
PY - 2020/6/2
Y1 - 2020/6/2
N2 - Involvement of dopamine in regulating exploration during decision-making has long been hypothesized, but direct causal evidence in humans is still lacking. Here, we use a combination of computational modeling, pharmacological intervention and functional magnetic resonance imaging to address this issue. Thirty-one healthy male participants performed a restless four-armed bandit task in a within-subjects design under three drug conditions: 150 mg of the dopamine precursor L-dopa, 2 mg of the D2 receptor antagonist haloperidol, and placebo. Choices were best explained by an extension of an established Bayesian learning model accounting for perseveration, directed exploration and random exploration. Modeling revealed attenuated directed exploration under L-dopa, while neural signatures of exploration, exploitation and prediction error were unaffected. Instead, L-dopa attenuated neural representations of overall uncertainty in insula and dorsal anterior cingulate cortex. Our results highlight the computational role of these regions in exploration and suggest that dopamine modulates how this circuit tracks accumulating uncertainty during decision-making.
AB - Involvement of dopamine in regulating exploration during decision-making has long been hypothesized, but direct causal evidence in humans is still lacking. Here, we use a combination of computational modeling, pharmacological intervention and functional magnetic resonance imaging to address this issue. Thirty-one healthy male participants performed a restless four-armed bandit task in a within-subjects design under three drug conditions: 150 mg of the dopamine precursor L-dopa, 2 mg of the D2 receptor antagonist haloperidol, and placebo. Choices were best explained by an extension of an established Bayesian learning model accounting for perseveration, directed exploration and random exploration. Modeling revealed attenuated directed exploration under L-dopa, while neural signatures of exploration, exploitation and prediction error were unaffected. Instead, L-dopa attenuated neural representations of overall uncertainty in insula and dorsal anterior cingulate cortex. Our results highlight the computational role of these regions in exploration and suggest that dopamine modulates how this circuit tracks accumulating uncertainty during decision-making.
U2 - 10.7554/eLife.51260
DO - 10.7554/eLife.51260
M3 - SCORING: Journal article
C2 - 32484779
VL - 9
SP - 1
EP - 44
JO - ELIFE
JF - ELIFE
SN - 2050-084X
ER -