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Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL

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Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL. / Prinz, Immo; Thamm, Kristina; Port, Matthias; Weissinger, Eva M; Stadler, Michael; Gabaev, Ildar; Jacobs, Roland; Ganser, Arnold; Koenecke, Christian.

In: EXP HEMATOL ONCOL, Vol. 2, No. 1, 11.05.2013, p. 14.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Prinz, I, Thamm, K, Port, M, Weissinger, EM, Stadler, M, Gabaev, I, Jacobs, R, Ganser, A & Koenecke, C 2013, 'Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL', EXP HEMATOL ONCOL, vol. 2, no. 1, pp. 14. https://doi.org/10.1186/2162-3619-2-14

APA

Prinz, I., Thamm, K., Port, M., Weissinger, E. M., Stadler, M., Gabaev, I., Jacobs, R., Ganser, A., & Koenecke, C. (2013). Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL. EXP HEMATOL ONCOL, 2(1), 14. https://doi.org/10.1186/2162-3619-2-14

Vancouver

Prinz I, Thamm K, Port M, Weissinger EM, Stadler M, Gabaev I et al. Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL. EXP HEMATOL ONCOL. 2013 May 11;2(1):14. https://doi.org/10.1186/2162-3619-2-14

Bibtex

@article{5c0cbf43b8c849f6a41e8b64ec926553,
title = "Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL",
abstract = "γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9-Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recently, Vδ1+ T lymphocytes were proposed to also have anti- B-CLL reactivity. Here we report a case of 48-year-old man who received allogeneic stem cell transplantation for progressive B-CLL. Within one year after transplantation, lymphoma relapsed despite a dramatic increase of Vδ1+ T cells in the patient's blood. In vitro killing assays revealed activity of patient's γδ cells against CMV target cells, but not against the relapsing lymphoma-cells. This argues for a contribution of Vδ1+ cells in the immune reaction against CMV reactivation, but does not support a strong correlation of expanded Vδ1+ T cells and favorable disease outcome in B-CLL patients.",
author = "Immo Prinz and Kristina Thamm and Matthias Port and Weissinger, {Eva M} and Michael Stadler and Ildar Gabaev and Roland Jacobs and Arnold Ganser and Christian Koenecke",
year = "2013",
month = may,
day = "11",
doi = "10.1186/2162-3619-2-14",
language = "English",
volume = "2",
pages = "14",
journal = "EXP HEMATOL ONCOL",
issn = "2162-3619",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL

AU - Prinz, Immo

AU - Thamm, Kristina

AU - Port, Matthias

AU - Weissinger, Eva M

AU - Stadler, Michael

AU - Gabaev, Ildar

AU - Jacobs, Roland

AU - Ganser, Arnold

AU - Koenecke, Christian

PY - 2013/5/11

Y1 - 2013/5/11

N2 - γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9-Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recently, Vδ1+ T lymphocytes were proposed to also have anti- B-CLL reactivity. Here we report a case of 48-year-old man who received allogeneic stem cell transplantation for progressive B-CLL. Within one year after transplantation, lymphoma relapsed despite a dramatic increase of Vδ1+ T cells in the patient's blood. In vitro killing assays revealed activity of patient's γδ cells against CMV target cells, but not against the relapsing lymphoma-cells. This argues for a contribution of Vδ1+ cells in the immune reaction against CMV reactivation, but does not support a strong correlation of expanded Vδ1+ T cells and favorable disease outcome in B-CLL patients.

AB - γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9-Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recently, Vδ1+ T lymphocytes were proposed to also have anti- B-CLL reactivity. Here we report a case of 48-year-old man who received allogeneic stem cell transplantation for progressive B-CLL. Within one year after transplantation, lymphoma relapsed despite a dramatic increase of Vδ1+ T cells in the patient's blood. In vitro killing assays revealed activity of patient's γδ cells against CMV target cells, but not against the relapsing lymphoma-cells. This argues for a contribution of Vδ1+ cells in the immune reaction against CMV reactivation, but does not support a strong correlation of expanded Vδ1+ T cells and favorable disease outcome in B-CLL patients.

U2 - 10.1186/2162-3619-2-14

DO - 10.1186/2162-3619-2-14

M3 - SCORING: Journal article

C2 - 23663319

VL - 2

SP - 14

JO - EXP HEMATOL ONCOL

JF - EXP HEMATOL ONCOL

SN - 2162-3619

IS - 1

ER -