Donor lymphocyte infusion enhances remission status in patients with persistent disease after allografting for multiple myeloma.
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Donor lymphocyte infusion enhances remission status in patients with persistent disease after allografting for multiple myeloma. / Kröger, N; Krüger, W; Renges, H; Zabelina, Tatjana; Stute, N; Jung, Roman; Wittkowsky, G; Kuse, R; Zander, A.
In: BRIT J HAEMATOL, Vol. 112, No. 2, 2, 2001, p. 421-423.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Donor lymphocyte infusion enhances remission status in patients with persistent disease after allografting for multiple myeloma.
AU - Kröger, N
AU - Krüger, W
AU - Renges, H
AU - Zabelina, Tatjana
AU - Stute, N
AU - Jung, Roman
AU - Wittkowsky, G
AU - Kuse, R
AU - Zander, A
PY - 2001
Y1 - 2001
N2 - Two patients with persistent disease after allografting for multiple myeloma received donor T-cell lymphocyte infusion (DLI) (1.5 x 10(8) and 7 x 10(7)) to induce a graft-vs.-myeloma effect for further tumour regression after withdrawal of immunosuppression. The interval between stem cell transplantation and DLI was 8 and 14 months respectively. Both patients converted from partial to complete remission, lasting 12+ and 28+ months. Immunofixation became negative after 3 and 4 months. The main toxicity was grade II and III acute graft-vs.-host disease (GvHD) and limited or extensive chronic GvHD in each patient. We conclude that DLI induced further tumour reduction in patients with persistent disease after allografting for multiple myeloma.
AB - Two patients with persistent disease after allografting for multiple myeloma received donor T-cell lymphocyte infusion (DLI) (1.5 x 10(8) and 7 x 10(7)) to induce a graft-vs.-myeloma effect for further tumour regression after withdrawal of immunosuppression. The interval between stem cell transplantation and DLI was 8 and 14 months respectively. Both patients converted from partial to complete remission, lasting 12+ and 28+ months. Immunofixation became negative after 3 and 4 months. The main toxicity was grade II and III acute graft-vs.-host disease (GvHD) and limited or extensive chronic GvHD in each patient. We conclude that DLI induced further tumour reduction in patients with persistent disease after allografting for multiple myeloma.
M3 - SCORING: Zeitschriftenaufsatz
VL - 112
SP - 421
EP - 423
JO - BRIT J HAEMATOL
JF - BRIT J HAEMATOL
SN - 0007-1048
IS - 2
M1 - 2
ER -