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Do reexcisions impair aesthetic outcome in breast conservation surgery? Exploratory analysis of a prospective cohort study

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Do reexcisions impair aesthetic outcome in breast conservation surgery? Exploratory analysis of a prospective cohort study. / Heil, Joerg; Breitkreuz, Kathrin; Golatta, Michael; Czink, Elena; Dahlkamp, Julia; Rom, Joachim; Schuetz, Florian; Blumenstein, Maria; Rauch, Geraldine; Sohn, Christof.

In: ANN SURG ONCOL, Vol. 19, No. 2, 02.2012, p. 541-547.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heil, J, Breitkreuz, K, Golatta, M, Czink, E, Dahlkamp, J, Rom, J, Schuetz, F, Blumenstein, M, Rauch, G & Sohn, C 2012, 'Do reexcisions impair aesthetic outcome in breast conservation surgery? Exploratory analysis of a prospective cohort study', ANN SURG ONCOL, vol. 19, no. 2, pp. 541-547. https://doi.org/10.1245/s10434-011-1947-1

APA

Heil, J., Breitkreuz, K., Golatta, M., Czink, E., Dahlkamp, J., Rom, J., Schuetz, F., Blumenstein, M., Rauch, G., & Sohn, C. (2012). Do reexcisions impair aesthetic outcome in breast conservation surgery? Exploratory analysis of a prospective cohort study. ANN SURG ONCOL, 19(2), 541-547. https://doi.org/10.1245/s10434-011-1947-1

Vancouver

Heil J, Breitkreuz K, Golatta M, Czink E, Dahlkamp J, Rom J et al. Do reexcisions impair aesthetic outcome in breast conservation surgery? Exploratory analysis of a prospective cohort study. ANN SURG ONCOL. 2012 Feb;19(2):541-547. https://doi.org/10.1245/s10434-011-1947-1

Bibtex

@article{1382e42cee3241be8fa3b1e5d9803b63,
title = "Do reexcisions impair aesthetic outcome in breast conservation surgery? Exploratory analysis of a prospective cohort study",
abstract = "PURPOSE: Reexcision is a clinically relevant aspect of oncological breast conservation surgery. The influence of reexcision on aesthetic outcome is described differently in the literature. Our aim was to analyze this question in a well-defined cohort with standardized study instruments.METHODS: A total of 439 patients from a prospectively followed cohort were included in this analysis. Aesthetic results were assessed by the Breast Cancer Treatment Outcome Scale (BCTOS) aesthetic status. Dates of assessments were shortly after surgical interventions and before surgery. Group comparison was performed between patients with reexcisions (80 cases; 18%) and patients without reexcision (359 cases; 82%). We considered variables of differing distribution between the two groups that could hypothetically influence BCTOS aesthetic status in a nonparametric analysis of covariance (ANCOVA).RESULTS: The aesthetic status of patients with reexcisions was found to be significantly worse than for patients with a single breast conservation surgery (P < 0.0001) when tested by a nonparametric ANCOVA model. Because patients with reexcisions had more noninvasive tumors (25% vs. 8%, P = 0.0001) and tumors were larger in patients with reexcision (P = 0.01), we included these variables as possible covariates in the multivariate model. The model was adjusted for the BCTOS aesthetic status before and shortly after the first surgery.CONCLUSIONS: Our findings suggest that reexcision in breast conservation surgery impairs aesthetic outcome, at least when assessed shortly after surgery.",
keywords = "Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Intraductal, Noninfiltrating, Female, Follow-Up Studies, Humans, Mastectomy, Segmental, Middle Aged, Neoplasm Invasiveness, Prospective Studies, Reoperation, Surgery, Plastic, Treatment Outcome, Clinical Trial, Journal Article",
author = "Joerg Heil and Kathrin Breitkreuz and Michael Golatta and Elena Czink and Julia Dahlkamp and Joachim Rom and Florian Schuetz and Maria Blumenstein and Geraldine Rauch and Christof Sohn",
year = "2012",
month = feb,
doi = "10.1245/s10434-011-1947-1",
language = "English",
volume = "19",
pages = "541--547",
journal = "ANN SURG ONCOL",
issn = "1068-9265",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Do reexcisions impair aesthetic outcome in breast conservation surgery? Exploratory analysis of a prospective cohort study

AU - Heil, Joerg

AU - Breitkreuz, Kathrin

AU - Golatta, Michael

AU - Czink, Elena

AU - Dahlkamp, Julia

AU - Rom, Joachim

AU - Schuetz, Florian

AU - Blumenstein, Maria

AU - Rauch, Geraldine

AU - Sohn, Christof

PY - 2012/2

Y1 - 2012/2

N2 - PURPOSE: Reexcision is a clinically relevant aspect of oncological breast conservation surgery. The influence of reexcision on aesthetic outcome is described differently in the literature. Our aim was to analyze this question in a well-defined cohort with standardized study instruments.METHODS: A total of 439 patients from a prospectively followed cohort were included in this analysis. Aesthetic results were assessed by the Breast Cancer Treatment Outcome Scale (BCTOS) aesthetic status. Dates of assessments were shortly after surgical interventions and before surgery. Group comparison was performed between patients with reexcisions (80 cases; 18%) and patients without reexcision (359 cases; 82%). We considered variables of differing distribution between the two groups that could hypothetically influence BCTOS aesthetic status in a nonparametric analysis of covariance (ANCOVA).RESULTS: The aesthetic status of patients with reexcisions was found to be significantly worse than for patients with a single breast conservation surgery (P < 0.0001) when tested by a nonparametric ANCOVA model. Because patients with reexcisions had more noninvasive tumors (25% vs. 8%, P = 0.0001) and tumors were larger in patients with reexcision (P = 0.01), we included these variables as possible covariates in the multivariate model. The model was adjusted for the BCTOS aesthetic status before and shortly after the first surgery.CONCLUSIONS: Our findings suggest that reexcision in breast conservation surgery impairs aesthetic outcome, at least when assessed shortly after surgery.

AB - PURPOSE: Reexcision is a clinically relevant aspect of oncological breast conservation surgery. The influence of reexcision on aesthetic outcome is described differently in the literature. Our aim was to analyze this question in a well-defined cohort with standardized study instruments.METHODS: A total of 439 patients from a prospectively followed cohort were included in this analysis. Aesthetic results were assessed by the Breast Cancer Treatment Outcome Scale (BCTOS) aesthetic status. Dates of assessments were shortly after surgical interventions and before surgery. Group comparison was performed between patients with reexcisions (80 cases; 18%) and patients without reexcision (359 cases; 82%). We considered variables of differing distribution between the two groups that could hypothetically influence BCTOS aesthetic status in a nonparametric analysis of covariance (ANCOVA).RESULTS: The aesthetic status of patients with reexcisions was found to be significantly worse than for patients with a single breast conservation surgery (P < 0.0001) when tested by a nonparametric ANCOVA model. Because patients with reexcisions had more noninvasive tumors (25% vs. 8%, P = 0.0001) and tumors were larger in patients with reexcision (P = 0.01), we included these variables as possible covariates in the multivariate model. The model was adjusted for the BCTOS aesthetic status before and shortly after the first surgery.CONCLUSIONS: Our findings suggest that reexcision in breast conservation surgery impairs aesthetic outcome, at least when assessed shortly after surgery.

KW - Breast Neoplasms

KW - Carcinoma, Ductal, Breast

KW - Carcinoma, Intraductal, Noninfiltrating

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Mastectomy, Segmental

KW - Middle Aged

KW - Neoplasm Invasiveness

KW - Prospective Studies

KW - Reoperation

KW - Surgery, Plastic

KW - Treatment Outcome

KW - Clinical Trial

KW - Journal Article

U2 - 10.1245/s10434-011-1947-1

DO - 10.1245/s10434-011-1947-1

M3 - SCORING: Journal article

C2 - 21761099

VL - 19

SP - 541

EP - 547

JO - ANN SURG ONCOL

JF - ANN SURG ONCOL

SN - 1068-9265

IS - 2

ER -