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Do patients with invasive lobular breast cancer benefit in terms of adequate change in surgical therapy from a supplementary preoperative breast MRI?

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Do patients with invasive lobular breast cancer benefit in terms of adequate change in surgical therapy from a supplementary preoperative breast MRI? / Heil, J; Buehler, A; Golatta, M; Rom, J; Schipp, A; Harcos, A; Schneeweiss, A; Rauch, G; Sohn, C; Junkermann, H.

In: ANN ONCOL, Vol. 23, No. 1, 01.2012, p. 98-104.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heil, J, Buehler, A, Golatta, M, Rom, J, Schipp, A, Harcos, A, Schneeweiss, A, Rauch, G, Sohn, C & Junkermann, H 2012, 'Do patients with invasive lobular breast cancer benefit in terms of adequate change in surgical therapy from a supplementary preoperative breast MRI?', ANN ONCOL, vol. 23, no. 1, pp. 98-104. https://doi.org/10.1093/annonc/mdr064

APA

Heil, J., Buehler, A., Golatta, M., Rom, J., Schipp, A., Harcos, A., Schneeweiss, A., Rauch, G., Sohn, C., & Junkermann, H. (2012). Do patients with invasive lobular breast cancer benefit in terms of adequate change in surgical therapy from a supplementary preoperative breast MRI? ANN ONCOL, 23(1), 98-104. https://doi.org/10.1093/annonc/mdr064

Vancouver

Heil J, Buehler A, Golatta M, Rom J, Schipp A, Harcos A et al. Do patients with invasive lobular breast cancer benefit in terms of adequate change in surgical therapy from a supplementary preoperative breast MRI? ANN ONCOL. 2012 Jan;23(1):98-104. https://doi.org/10.1093/annonc/mdr064

Bibtex

@article{5d78338993224838aa10d672bde3868e,
title = "Do patients with invasive lobular breast cancer benefit in terms of adequate change in surgical therapy from a supplementary preoperative breast MRI?",
abstract = "BACKGROUND: Breast magnetic resonance imaging (MRI) has been introduced in the preoperative management of invasive lobular breast cancer (ILC). We analysed if MRI leads to adequate changes in surgical management.PATIENTS AND METHODS: We carried out a single-centre retrospective confirmatory analysis of 92 patients with ILC and a preoperative breast MRI. By applying a blinded tumour board method, we analysed if surgical procedures were altered due to breast MRI. In case of alteration, we analysed whether the change was adequate according to the postoperative pathology findings. We considered an adequate rate of change>5% to be a clinically relevant benefit.RESULTS: A change in surgical therapy due to the MRI findings occurred in 23 of 92 patients (25%). According to the postoperative pathology findings, this change was adequate for 20 of these patients (22%; 95% confidence interval [CI] 14%-31%, P<0.0001). An overtreatment occurred for three patients (3%; 95% CI 0%-6%) who underwent a mastectomy following the results of breast MRI. Patients with larger tumours did likely benefit more from preoperative breast MRI.CONCLUSIONS: Patients with ILC might benefit from a preoperative breast MRI. Possible harm from overtreatment should be minimised by diligent use of preoperative histological clarification.",
keywords = "Breast Neoplasms, Carcinoma, Lobular, Female, Humans, Magnetic Resonance Imaging, Mastectomy, Neoplasm Staging, Preoperative Care, Retrospective Studies, Journal Article",
author = "J Heil and A Buehler and M Golatta and J Rom and A Schipp and A Harcos and A Schneeweiss and G Rauch and C Sohn and H Junkermann",
year = "2012",
month = jan,
doi = "10.1093/annonc/mdr064",
language = "English",
volume = "23",
pages = "98--104",
journal = "ANN ONCOL",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Do patients with invasive lobular breast cancer benefit in terms of adequate change in surgical therapy from a supplementary preoperative breast MRI?

AU - Heil, J

AU - Buehler, A

AU - Golatta, M

AU - Rom, J

AU - Schipp, A

AU - Harcos, A

AU - Schneeweiss, A

AU - Rauch, G

AU - Sohn, C

AU - Junkermann, H

PY - 2012/1

Y1 - 2012/1

N2 - BACKGROUND: Breast magnetic resonance imaging (MRI) has been introduced in the preoperative management of invasive lobular breast cancer (ILC). We analysed if MRI leads to adequate changes in surgical management.PATIENTS AND METHODS: We carried out a single-centre retrospective confirmatory analysis of 92 patients with ILC and a preoperative breast MRI. By applying a blinded tumour board method, we analysed if surgical procedures were altered due to breast MRI. In case of alteration, we analysed whether the change was adequate according to the postoperative pathology findings. We considered an adequate rate of change>5% to be a clinically relevant benefit.RESULTS: A change in surgical therapy due to the MRI findings occurred in 23 of 92 patients (25%). According to the postoperative pathology findings, this change was adequate for 20 of these patients (22%; 95% confidence interval [CI] 14%-31%, P<0.0001). An overtreatment occurred for three patients (3%; 95% CI 0%-6%) who underwent a mastectomy following the results of breast MRI. Patients with larger tumours did likely benefit more from preoperative breast MRI.CONCLUSIONS: Patients with ILC might benefit from a preoperative breast MRI. Possible harm from overtreatment should be minimised by diligent use of preoperative histological clarification.

AB - BACKGROUND: Breast magnetic resonance imaging (MRI) has been introduced in the preoperative management of invasive lobular breast cancer (ILC). We analysed if MRI leads to adequate changes in surgical management.PATIENTS AND METHODS: We carried out a single-centre retrospective confirmatory analysis of 92 patients with ILC and a preoperative breast MRI. By applying a blinded tumour board method, we analysed if surgical procedures were altered due to breast MRI. In case of alteration, we analysed whether the change was adequate according to the postoperative pathology findings. We considered an adequate rate of change>5% to be a clinically relevant benefit.RESULTS: A change in surgical therapy due to the MRI findings occurred in 23 of 92 patients (25%). According to the postoperative pathology findings, this change was adequate for 20 of these patients (22%; 95% confidence interval [CI] 14%-31%, P<0.0001). An overtreatment occurred for three patients (3%; 95% CI 0%-6%) who underwent a mastectomy following the results of breast MRI. Patients with larger tumours did likely benefit more from preoperative breast MRI.CONCLUSIONS: Patients with ILC might benefit from a preoperative breast MRI. Possible harm from overtreatment should be minimised by diligent use of preoperative histological clarification.

KW - Breast Neoplasms

KW - Carcinoma, Lobular

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Mastectomy

KW - Neoplasm Staging

KW - Preoperative Care

KW - Retrospective Studies

KW - Journal Article

U2 - 10.1093/annonc/mdr064

DO - 10.1093/annonc/mdr064

M3 - SCORING: Journal article

C2 - 21460377

VL - 23

SP - 98

EP - 104

JO - ANN ONCOL

JF - ANN ONCOL

SN - 0923-7534

IS - 1

ER -