[Do opioids induce hyperalgesia?].
Standard
[Do opioids induce hyperalgesia?]. / Zöllner, Christian.
In: ANAESTHESIST, Vol. 59, No. 11, 11, 2010, p. 983-986, 988-993.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - [Do opioids induce hyperalgesia?].
AU - Zöllner, Christian
PY - 2010
Y1 - 2010
N2 - Opioids are the most potent drugs for treatment of acute and chronic pain. However, accumulating evidence suggests that opioids may paradoxically also enhance pain, often referred to as opioid-induced hyperalgesia. Opioid-induced hyperalgesia is defined as an increased sensitivity to pain or a decreased pain threshold in response to opioid therapy. Several mechanisms have been proposed to support opioid-induced hyperalgesia. However, it remains unclear whether opioid-induced hyperalgesia develops during continuous chronic application of opioids or on their withdrawal. This review provides a comprehensive summary of clinical research concerning opioid-induced hyperalgesia and the molecular mechanisms of opioid withdrawal and opioid tolerance and other potential mechanisms which might induce hyperalgesia during opioid therapy will be discussed. The status quo of our knowledge will be summarized and the clinical relevance of opioid-induced hyperalgesia will be discussed.
AB - Opioids are the most potent drugs for treatment of acute and chronic pain. However, accumulating evidence suggests that opioids may paradoxically also enhance pain, often referred to as opioid-induced hyperalgesia. Opioid-induced hyperalgesia is defined as an increased sensitivity to pain or a decreased pain threshold in response to opioid therapy. Several mechanisms have been proposed to support opioid-induced hyperalgesia. However, it remains unclear whether opioid-induced hyperalgesia develops during continuous chronic application of opioids or on their withdrawal. This review provides a comprehensive summary of clinical research concerning opioid-induced hyperalgesia and the molecular mechanisms of opioid withdrawal and opioid tolerance and other potential mechanisms which might induce hyperalgesia during opioid therapy will be discussed. The status quo of our knowledge will be summarized and the clinical relevance of opioid-induced hyperalgesia will be discussed.
KW - Animals
KW - Humans
KW - Analgesics, Opioid adverse effects
KW - Drug Tolerance
KW - Hyperalgesia chemically induced
KW - Morphine adverse effects
KW - Nociceptors drug effects
KW - Pain complications
KW - Pain Threshold drug effects
KW - Receptors, Opioid drug effects
KW - Substance Withdrawal Syndrome psychology
KW - Animals
KW - Humans
KW - Analgesics, Opioid adverse effects
KW - Drug Tolerance
KW - Hyperalgesia chemically induced
KW - Morphine adverse effects
KW - Nociceptors drug effects
KW - Pain complications
KW - Pain Threshold drug effects
KW - Receptors, Opioid drug effects
KW - Substance Withdrawal Syndrome psychology
M3 - SCORING: Zeitschriftenaufsatz
VL - 59
SP - 983-986, 988-993
JO - ANAESTHESIST
JF - ANAESTHESIST
SN - 0003-2417
IS - 11
M1 - 11
ER -
