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Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions

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Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions. / Siebers, Michael; Biedermann, Sarah V; Fuß, Johannes.

In: NEUROSCIENTIST, Vol. 29, No. 3, 06.2023, p. 352-369.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Siebers, M, Biedermann, SV & Fuß, J 2023, 'Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions', NEUROSCIENTIST, vol. 29, no. 3, pp. 352-369. https://doi.org/10.1177/10738584211069981

APA

Siebers, M., Biedermann, S. V., & Fuß, J. (2023). Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions. NEUROSCIENTIST, 29(3), 352-369. https://doi.org/10.1177/10738584211069981

Vancouver

Siebers M, Biedermann SV, Fuß J. Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions. NEUROSCIENTIST. 2023 Jun;29(3):352-369. https://doi.org/10.1177/10738584211069981

Bibtex

@article{521349300c344b0dacb44520259455c0,
title = "Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions",
abstract = "The runner{\textquoteright}s high is an ephemeral feeling some humans experience during and after endurance exercise. Recent evidence in mice suggests that a runner{\textquoteright}s high depends on the release of endocannabinoids (eCBs) during exercise. However, little is known under what circumstances eCBs are released during exercise in humans. This systematic review sampled all data from clinical trials in humans on eCB levels following exercise from the discovery of eCBs until April 20, 2021. PubMed/NCBI, Ovid MEDLINE, and Cochrane library were searched systematically and reviewed following the PRISMA guidelines. From 278 records, 21 met the inclusion criteria. After acute exercise, 14 of 17 studies detected an increase in eCBs. In contrast, after a period of long-term endurance exercise, four articles described a decrease in eCBs. Even though several studies demonstrated an association between eCB levels and features of the runner{\textquoteright}s high, reliable proof of the involvement of eCBs in the runner{\textquoteright}s high in humans has not yet been achieved due to methodological hurdles. In this review, we suggest how to advance the study of the influence of eCBs on the beneficial effects of exercise and provide recommendations on how endocannabinoid release is most likely to occur under laboratory conditions.",
keywords = "Animals, Emotions, Endocannabinoids, Humans, Mice, Physical Conditioning, Animal, Running",
author = "Michael Siebers and Biedermann, {Sarah V} and Johannes Fu{\ss}",
year = "2023",
month = jun,
doi = "10.1177/10738584211069981",
language = "English",
volume = "29",
pages = "352--369",
journal = "NEUROSCIENTIST",
issn = "1073-8584",
publisher = "SAGE Publications",
number = "3",

}

RIS

TY - JOUR

T1 - Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions

AU - Siebers, Michael

AU - Biedermann, Sarah V

AU - Fuß, Johannes

PY - 2023/6

Y1 - 2023/6

N2 - The runner’s high is an ephemeral feeling some humans experience during and after endurance exercise. Recent evidence in mice suggests that a runner’s high depends on the release of endocannabinoids (eCBs) during exercise. However, little is known under what circumstances eCBs are released during exercise in humans. This systematic review sampled all data from clinical trials in humans on eCB levels following exercise from the discovery of eCBs until April 20, 2021. PubMed/NCBI, Ovid MEDLINE, and Cochrane library were searched systematically and reviewed following the PRISMA guidelines. From 278 records, 21 met the inclusion criteria. After acute exercise, 14 of 17 studies detected an increase in eCBs. In contrast, after a period of long-term endurance exercise, four articles described a decrease in eCBs. Even though several studies demonstrated an association between eCB levels and features of the runner’s high, reliable proof of the involvement of eCBs in the runner’s high in humans has not yet been achieved due to methodological hurdles. In this review, we suggest how to advance the study of the influence of eCBs on the beneficial effects of exercise and provide recommendations on how endocannabinoid release is most likely to occur under laboratory conditions.

AB - The runner’s high is an ephemeral feeling some humans experience during and after endurance exercise. Recent evidence in mice suggests that a runner’s high depends on the release of endocannabinoids (eCBs) during exercise. However, little is known under what circumstances eCBs are released during exercise in humans. This systematic review sampled all data from clinical trials in humans on eCB levels following exercise from the discovery of eCBs until April 20, 2021. PubMed/NCBI, Ovid MEDLINE, and Cochrane library were searched systematically and reviewed following the PRISMA guidelines. From 278 records, 21 met the inclusion criteria. After acute exercise, 14 of 17 studies detected an increase in eCBs. In contrast, after a period of long-term endurance exercise, four articles described a decrease in eCBs. Even though several studies demonstrated an association between eCB levels and features of the runner’s high, reliable proof of the involvement of eCBs in the runner’s high in humans has not yet been achieved due to methodological hurdles. In this review, we suggest how to advance the study of the influence of eCBs on the beneficial effects of exercise and provide recommendations on how endocannabinoid release is most likely to occur under laboratory conditions.

KW - Animals

KW - Emotions

KW - Endocannabinoids

KW - Humans

KW - Mice

KW - Physical Conditioning, Animal

KW - Running

U2 - 10.1177/10738584211069981

DO - 10.1177/10738584211069981

M3 - SCORING: Review article

C2 - 35081831

VL - 29

SP - 352

EP - 369

JO - NEUROSCIENTIST

JF - NEUROSCIENTIST

SN - 1073-8584

IS - 3

ER -