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Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients?

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Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients? / Tomaske, Maren; Harpes, Paul; Dodge-Khatami, Ali; Amacker, Nadja; Bauersfeld, Urs.

In: EUROPACE, Vol. 9, No. 8, 08.2007, p. 662-668.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tomaske, M, Harpes, P, Dodge-Khatami, A, Amacker, N & Bauersfeld, U 2007, 'Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients?', EUROPACE, vol. 9, no. 8, pp. 662-668. https://doi.org/10.1093/europace/eum100

APA

Tomaske, M., Harpes, P., Dodge-Khatami, A., Amacker, N., & Bauersfeld, U. (2007). Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients? EUROPACE, 9(8), 662-668. https://doi.org/10.1093/europace/eum100

Vancouver

Tomaske M, Harpes P, Dodge-Khatami A, Amacker N, Bauersfeld U. Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients? EUROPACE. 2007 Aug;9(8):662-668. https://doi.org/10.1093/europace/eum100

Bibtex

@article{6527e663c8b04a9d958292654a37c007,
title = "Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients?",
abstract = "AIMS: To evaluate whether the magnitude of daily ventricular pacing threshold fluctuations (Deltafluctuation) in trend graphs of stored diagrams correlate with ventricular threshold and sensing changes over time.METHODS AND RESULTS: A total of 56 children received AutoCapture devices (St. Jude Medical, Sylmar, CA, USA) connected to steroid-eluting epicardial leads. Maximum lead age at study closure was 12.2 years (median 4.0). Telemetry data and daily Deltafluctuation were obtained every 6 months. Regression slope coefficients and mean values of repeated measurements were calculated for each patient's course. High daily Deltafluctuation correlated with higher pacing thresholds (rho = 0.68, P < 0.001), lower impedances (rho = -0.38, P = 0.004), and a Deltafluctuation-incline (rho = 0.34, P = 0.01) over time. Furthermore, a Deltafluctuation-incline correlated with a pacing threshold-incline (rho = 0.34, P = 0.01). No correlation was observed for ventricular sensing. Higher daily Deltafluctuation were observed if lead age was > 5 years compared with CONCLUSION: High amplitudes of daily Deltafluctuation correlate with higher and increasing pacing thresholds and lower impedances. Theoretically, this results from electrode microinstability on the epicardial surface. A decrease of the steroid-eluting potency of the electrode can be hypothesized to cause higher daily Deltafluctuation beyond a lead age of 5 years. Potential implications of marked daily Deltafluctuation are short-term follow-up and lead replacement in the presence of high pacing thresholds.",
keywords = "Cardiac Pacing, Artificial/methods, Child, Child, Preschool, Differential Threshold, Electrocardiography/methods, Electrodes, Implanted, Female, Humans, Male, Pericardium, Reproducibility of Results, Sensitivity and Specificity, Therapy, Computer-Assisted/methods, Ventricular Fibrillation/diagnosis",
author = "Maren Tomaske and Paul Harpes and Ali Dodge-Khatami and Nadja Amacker and Urs Bauersfeld",
year = "2007",
month = aug,
doi = "10.1093/europace/eum100",
language = "English",
volume = "9",
pages = "662--668",
journal = "EUROPACE",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients?

AU - Tomaske, Maren

AU - Harpes, Paul

AU - Dodge-Khatami, Ali

AU - Amacker, Nadja

AU - Bauersfeld, Urs

PY - 2007/8

Y1 - 2007/8

N2 - AIMS: To evaluate whether the magnitude of daily ventricular pacing threshold fluctuations (Deltafluctuation) in trend graphs of stored diagrams correlate with ventricular threshold and sensing changes over time.METHODS AND RESULTS: A total of 56 children received AutoCapture devices (St. Jude Medical, Sylmar, CA, USA) connected to steroid-eluting epicardial leads. Maximum lead age at study closure was 12.2 years (median 4.0). Telemetry data and daily Deltafluctuation were obtained every 6 months. Regression slope coefficients and mean values of repeated measurements were calculated for each patient's course. High daily Deltafluctuation correlated with higher pacing thresholds (rho = 0.68, P < 0.001), lower impedances (rho = -0.38, P = 0.004), and a Deltafluctuation-incline (rho = 0.34, P = 0.01) over time. Furthermore, a Deltafluctuation-incline correlated with a pacing threshold-incline (rho = 0.34, P = 0.01). No correlation was observed for ventricular sensing. Higher daily Deltafluctuation were observed if lead age was > 5 years compared with CONCLUSION: High amplitudes of daily Deltafluctuation correlate with higher and increasing pacing thresholds and lower impedances. Theoretically, this results from electrode microinstability on the epicardial surface. A decrease of the steroid-eluting potency of the electrode can be hypothesized to cause higher daily Deltafluctuation beyond a lead age of 5 years. Potential implications of marked daily Deltafluctuation are short-term follow-up and lead replacement in the presence of high pacing thresholds.

AB - AIMS: To evaluate whether the magnitude of daily ventricular pacing threshold fluctuations (Deltafluctuation) in trend graphs of stored diagrams correlate with ventricular threshold and sensing changes over time.METHODS AND RESULTS: A total of 56 children received AutoCapture devices (St. Jude Medical, Sylmar, CA, USA) connected to steroid-eluting epicardial leads. Maximum lead age at study closure was 12.2 years (median 4.0). Telemetry data and daily Deltafluctuation were obtained every 6 months. Regression slope coefficients and mean values of repeated measurements were calculated for each patient's course. High daily Deltafluctuation correlated with higher pacing thresholds (rho = 0.68, P < 0.001), lower impedances (rho = -0.38, P = 0.004), and a Deltafluctuation-incline (rho = 0.34, P = 0.01) over time. Furthermore, a Deltafluctuation-incline correlated with a pacing threshold-incline (rho = 0.34, P = 0.01). No correlation was observed for ventricular sensing. Higher daily Deltafluctuation were observed if lead age was > 5 years compared with CONCLUSION: High amplitudes of daily Deltafluctuation correlate with higher and increasing pacing thresholds and lower impedances. Theoretically, this results from electrode microinstability on the epicardial surface. A decrease of the steroid-eluting potency of the electrode can be hypothesized to cause higher daily Deltafluctuation beyond a lead age of 5 years. Potential implications of marked daily Deltafluctuation are short-term follow-up and lead replacement in the presence of high pacing thresholds.

KW - Cardiac Pacing, Artificial/methods

KW - Child

KW - Child, Preschool

KW - Differential Threshold

KW - Electrocardiography/methods

KW - Electrodes, Implanted

KW - Female

KW - Humans

KW - Male

KW - Pericardium

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Therapy, Computer-Assisted/methods

KW - Ventricular Fibrillation/diagnosis

U2 - 10.1093/europace/eum100

DO - 10.1093/europace/eum100

M3 - SCORING: Journal article

C2 - 17573359

VL - 9

SP - 662

EP - 668

JO - EUROPACE

JF - EUROPACE

SN - 1099-5129

IS - 8

ER -