[Do advers health effects of chrysotile and amphibole asbestos differ?].
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[Do advers health effects of chrysotile and amphibole asbestos differ?]. / Baur, Xaver; Schneider, J; Woitowitz, H-J; Velasco Garrido, Marcial.
In: PNEUMOLOGIE, Vol. 66, No. 8, 8, 2012, p. 497-506.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - [Do advers health effects of chrysotile and amphibole asbestos differ?].
AU - Baur, Xaver
AU - Schneider, J
AU - Woitowitz, H-J
AU - Velasco Garrido, Marcial
PY - 2012
Y1 - 2012
N2 - Due to the current query whether the predominantly used chrysotile (white) asbestos comprises health risks we performed a literature search including in vitro and animal experiments as well as epidemiological studies.As shown by epidemiological studies chrysotile causes less pleural fibrosis and mesotheliomas when compared with other asbestos types. However, its otherwise inflammatory, toxic, carcinogenic, and fibrosis-inducing effects correspond to those of other occupationally relevant asbestos types. This is based on clinical, animal as well as on in-vitro findings. This means that denying a causal relationship, e. g. in a case with lung fibrosis (= asbestosis) or lung cancer with an asbestos load of 25 fiber-years in the absence of identification of a significant concentration of asbestos fibers or asbestos bodies in the lung (see so-called "hit and run" phenomenon), contradicts the medical-scientific knowledge.
AB - Due to the current query whether the predominantly used chrysotile (white) asbestos comprises health risks we performed a literature search including in vitro and animal experiments as well as epidemiological studies.As shown by epidemiological studies chrysotile causes less pleural fibrosis and mesotheliomas when compared with other asbestos types. However, its otherwise inflammatory, toxic, carcinogenic, and fibrosis-inducing effects correspond to those of other occupationally relevant asbestos types. This is based on clinical, animal as well as on in-vitro findings. This means that denying a causal relationship, e. g. in a case with lung fibrosis (= asbestosis) or lung cancer with an asbestos load of 25 fiber-years in the absence of identification of a significant concentration of asbestos fibers or asbestos bodies in the lung (see so-called "hit and run" phenomenon), contradicts the medical-scientific knowledge.
KW - Humans
KW - Risk Factors
KW - Survival Analysis
KW - Survival Rate
KW - Prevalence
KW - Evidence-Based Medicine
KW - Asbestos, Amphibole/poisoning
KW - Asbestos, Serpentine/poisoning
KW - Asbestosis/etiology/mortality
KW - Literature Based Discovery
KW - Lung Neoplasms/chemically induced/mortality
KW - Humans
KW - Risk Factors
KW - Survival Analysis
KW - Survival Rate
KW - Prevalence
KW - Evidence-Based Medicine
KW - Asbestos, Amphibole/poisoning
KW - Asbestos, Serpentine/poisoning
KW - Asbestosis/etiology/mortality
KW - Literature Based Discovery
KW - Lung Neoplasms/chemically induced/mortality
M3 - SCORING: Zeitschriftenaufsatz
VL - 66
SP - 497
EP - 506
JO - PNEUMOLOGIE
JF - PNEUMOLOGIE
SN - 0934-8387
IS - 8
M1 - 8
ER -