Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons.
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Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. / Hack, Iris; Hellwig, Sabine; Junghans, Dirk; Brunne, Bianka; Bock, Hans H; Zhao, Shanting; Frotscher, Michael.
In: DEVELOPMENT, Vol. 134, No. 21, 21, 2007, p. 3883-3891.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons.
AU - Hack, Iris
AU - Hellwig, Sabine
AU - Junghans, Dirk
AU - Brunne, Bianka
AU - Bock, Hans H
AU - Zhao, Shanting
AU - Frotscher, Michael
PY - 2007
Y1 - 2007
N2 - Reelin, its lipoprotein receptors [very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1) are important for the correct formation of layers in the cerebral cortex. Reeler mice lacking the reelin protein show altered radial neuronal migration resulting in an inversion of cortical layers. ApoER2 Vldlr double-knockout mutants and Dab1 mutants show a reeler-like phenotype, whereas milder phenotypes are found if only one of the two lipoprotein receptors for reelin is absent. However, the precise role of the individual reelin receptors in neuronal migration remained unclear. In the study reported here, we performed fate mapping of newly generated cortical neurons in single and double receptor mutants using bromodeoxyuridine-labeling and layer-specific markers. We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons.
AB - Reelin, its lipoprotein receptors [very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1) are important for the correct formation of layers in the cerebral cortex. Reeler mice lacking the reelin protein show altered radial neuronal migration resulting in an inversion of cortical layers. ApoER2 Vldlr double-knockout mutants and Dab1 mutants show a reeler-like phenotype, whereas milder phenotypes are found if only one of the two lipoprotein receptors for reelin is absent. However, the precise role of the individual reelin receptors in neuronal migration remained unclear. In the study reported here, we performed fate mapping of newly generated cortical neurons in single and double receptor mutants using bromodeoxyuridine-labeling and layer-specific markers. We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons.
KW - Animals
KW - Mice
KW - Mice, Knockout
KW - Cell Movement
KW - Mutation genetics
KW - Gene Expression Regulation, Developmental
KW - DNA-Binding Proteins metabolism
KW - Neuroglia metabolism
KW - Neurons cytology
KW - Receptors, LDL deficiency
KW - Receptors, Lipoprotein deficiency
KW - Repressor Proteins metabolism
KW - Transcription, Genetic genetics
KW - Animals
KW - Mice
KW - Mice, Knockout
KW - Cell Movement
KW - Mutation genetics
KW - Gene Expression Regulation, Developmental
KW - DNA-Binding Proteins metabolism
KW - Neuroglia metabolism
KW - Neurons cytology
KW - Receptors, LDL deficiency
KW - Receptors, Lipoprotein deficiency
KW - Repressor Proteins metabolism
KW - Transcription, Genetic genetics
M3 - SCORING: Zeitschriftenaufsatz
VL - 134
SP - 3883
EP - 3891
JO - DEVELOPMENT
JF - DEVELOPMENT
SN - 0950-1991
IS - 21
M1 - 21
ER -
