Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities
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Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities. / Sydow, Karsten; Fortmann, Stephen P; Fair, Joan M; Varady, Ann; Hlatky, Mark A; Go, Alan S; Iribarren, Carlos; Tsao, Philip S; ADVANCE Investigators.
In: CLIN CHEM, Vol. 56, No. 1, 01.2010, p. 111-120.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities
AU - Sydow, Karsten
AU - Fortmann, Stephen P
AU - Fair, Joan M
AU - Varady, Ann
AU - Hlatky, Mark A
AU - Go, Alan S
AU - Iribarren, Carlos
AU - Tsao, Philip S
AU - ADVANCE Investigators
PY - 2010/1
Y1 - 2010/1
N2 - BACKGROUND: Endothelium-derived nitric oxide plays a crucial role in the regulation of vascular tone and the development of cardiovascular disease. The endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) has emerged as a novel cardiovascular risk factor. ADMA appears to be an independent predictor for cardiovascular and overall mortality. However, the majority of studies investigating the clinical role of ADMA were performed in European study populations with few individuals of other ethnicities.METHODS: We performed a cross-sectional study of 980 healthy, older (age 60-72 years) individuals of different ethnicities living in the San Francisco Bay area and analyzed ADMA plasma concentrations and their relationship to other cardiovascular risk factors. Plasma ADMA concentrations were measured using a recently developed, highly sensitive ELISA.RESULTS: In our entire sample, we were able to define a reference interval for ADMA plasma concentrations of 0.47 (90% CI 0.46-0.48) mumol/L to 0.85 (0.84-0.89) mumol/L. The mean ADMA concentration was 0.63 (SD 0.11) mumol/L (median 0.61 mumol/L). Mean ADMA concentrations were significantly lower in African Americans (0.60 mumol/L; P < 0.01) and mixed non-Hispanics (0.60 mumol/L; P < 0.05) compared with whites (0.63 mumol/L). ADMA was positively correlated with cystatin-C in both men (rho = 0.29) and women (rho = 0.37), and median plasma ADMA concentrations increased across cystatin-C quintiles.CONCLUSIONS: ADMA varies nearly 2-fold across a healthy sample of older men and women, correlates with age, body mass index, and renal function, and is different across ethnic groups. Additional studies in a wider age range and including larger ethnic subgroups would be useful.
AB - BACKGROUND: Endothelium-derived nitric oxide plays a crucial role in the regulation of vascular tone and the development of cardiovascular disease. The endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) has emerged as a novel cardiovascular risk factor. ADMA appears to be an independent predictor for cardiovascular and overall mortality. However, the majority of studies investigating the clinical role of ADMA were performed in European study populations with few individuals of other ethnicities.METHODS: We performed a cross-sectional study of 980 healthy, older (age 60-72 years) individuals of different ethnicities living in the San Francisco Bay area and analyzed ADMA plasma concentrations and their relationship to other cardiovascular risk factors. Plasma ADMA concentrations were measured using a recently developed, highly sensitive ELISA.RESULTS: In our entire sample, we were able to define a reference interval for ADMA plasma concentrations of 0.47 (90% CI 0.46-0.48) mumol/L to 0.85 (0.84-0.89) mumol/L. The mean ADMA concentration was 0.63 (SD 0.11) mumol/L (median 0.61 mumol/L). Mean ADMA concentrations were significantly lower in African Americans (0.60 mumol/L; P < 0.01) and mixed non-Hispanics (0.60 mumol/L; P < 0.05) compared with whites (0.63 mumol/L). ADMA was positively correlated with cystatin-C in both men (rho = 0.29) and women (rho = 0.37), and median plasma ADMA concentrations increased across cystatin-C quintiles.CONCLUSIONS: ADMA varies nearly 2-fold across a healthy sample of older men and women, correlates with age, body mass index, and renal function, and is different across ethnic groups. Additional studies in a wider age range and including larger ethnic subgroups would be useful.
KW - African Continental Ancestry Group
KW - Aged
KW - Arginine/analogs & derivatives
KW - Asian Continental Ancestry Group
KW - Cardiovascular Diseases/etiology
KW - Cystatin C/blood
KW - Enzyme-Linked Immunosorbent Assay
KW - European Continental Ancestry Group
KW - Female
KW - Glomerular Filtration Rate
KW - Hispanic Americans
KW - Humans
KW - Male
KW - Middle Aged
KW - Regression Analysis
KW - Risk Factors
U2 - 10.1373/clinchem.2009.136200
DO - 10.1373/clinchem.2009.136200
M3 - SCORING: Journal article
C2 - 19892843
VL - 56
SP - 111
EP - 120
JO - CLIN CHEM
JF - CLIN CHEM
SN - 0009-9147
IS - 1
ER -
