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Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice

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Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice. / Dieni, Sandra; Nestel, Sigrun; Sibbe, Mirjam; Frotscher, Michael; Hellwig, Sabine.

In: FRONT SYNAPTIC NEURO, Vol. 7, 23.10.2015, p. 18.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dieni, S, Nestel, S, Sibbe, M, Frotscher, M & Hellwig, S 2015, 'Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice', FRONT SYNAPTIC NEURO, vol. 7, pp. 18. https://doi.org/10.3389/fnsyn.2015.00018

APA

Dieni, S., Nestel, S., Sibbe, M., Frotscher, M., & Hellwig, S. (2015). Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice. FRONT SYNAPTIC NEURO, 7, 18. https://doi.org/10.3389/fnsyn.2015.00018

Vancouver

Dieni S, Nestel S, Sibbe M, Frotscher M, Hellwig S. Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice. FRONT SYNAPTIC NEURO. 2015 Oct 23;7:18. https://doi.org/10.3389/fnsyn.2015.00018

Bibtex

@article{a7c5c59525834ca0b28ba97ac39d4dc3,
title = "Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice",
abstract = "Proper synaptic function depends on a finely-tuned balance between events such as protein synthesis and structural organization. In particular, the functional loss of just one synaptic-related protein can have a profound impact on overall neuronal network function. To this end, we used a mutant mouse model harboring a mutated form of the presynaptic scaffolding protein Bassoon (Bsn), which is phenotypically characterized by: (i) spontaneous generalized epileptic seizure activity, representing a chronically-imbalanced neuronal network; and (ii) a dramatic increase in hippocampal brain-derived neurotrophic factor (BDNF) protein concentration, a key player in synaptic plasticity. Detailed morphological and neurochemical analyses revealed that the increased BDNF levels are associated with: (i) modified neuropeptide distribution; (ii) perturbed expression of selected markers of synaptic activation or plasticity; (iii) subtle changes to microglial structure; and (iv) morphological alterations to the mossy fiber (MF) synapse. These findings emphasize the important contribution of Bassoon protein to normal hippocampal function, and further characterize the Bsn-mutant as a useful model for studying the effects of chronic changes to network activity.",
author = "Sandra Dieni and Sigrun Nestel and Mirjam Sibbe and Michael Frotscher and Sabine Hellwig",
year = "2015",
month = oct,
day = "23",
doi = "10.3389/fnsyn.2015.00018",
language = "English",
volume = "7",
pages = "18",
journal = "FRONT SYNAPTIC NEURO",
issn = "1663-3563",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice

AU - Dieni, Sandra

AU - Nestel, Sigrun

AU - Sibbe, Mirjam

AU - Frotscher, Michael

AU - Hellwig, Sabine

PY - 2015/10/23

Y1 - 2015/10/23

N2 - Proper synaptic function depends on a finely-tuned balance between events such as protein synthesis and structural organization. In particular, the functional loss of just one synaptic-related protein can have a profound impact on overall neuronal network function. To this end, we used a mutant mouse model harboring a mutated form of the presynaptic scaffolding protein Bassoon (Bsn), which is phenotypically characterized by: (i) spontaneous generalized epileptic seizure activity, representing a chronically-imbalanced neuronal network; and (ii) a dramatic increase in hippocampal brain-derived neurotrophic factor (BDNF) protein concentration, a key player in synaptic plasticity. Detailed morphological and neurochemical analyses revealed that the increased BDNF levels are associated with: (i) modified neuropeptide distribution; (ii) perturbed expression of selected markers of synaptic activation or plasticity; (iii) subtle changes to microglial structure; and (iv) morphological alterations to the mossy fiber (MF) synapse. These findings emphasize the important contribution of Bassoon protein to normal hippocampal function, and further characterize the Bsn-mutant as a useful model for studying the effects of chronic changes to network activity.

AB - Proper synaptic function depends on a finely-tuned balance between events such as protein synthesis and structural organization. In particular, the functional loss of just one synaptic-related protein can have a profound impact on overall neuronal network function. To this end, we used a mutant mouse model harboring a mutated form of the presynaptic scaffolding protein Bassoon (Bsn), which is phenotypically characterized by: (i) spontaneous generalized epileptic seizure activity, representing a chronically-imbalanced neuronal network; and (ii) a dramatic increase in hippocampal brain-derived neurotrophic factor (BDNF) protein concentration, a key player in synaptic plasticity. Detailed morphological and neurochemical analyses revealed that the increased BDNF levels are associated with: (i) modified neuropeptide distribution; (ii) perturbed expression of selected markers of synaptic activation or plasticity; (iii) subtle changes to microglial structure; and (iv) morphological alterations to the mossy fiber (MF) synapse. These findings emphasize the important contribution of Bassoon protein to normal hippocampal function, and further characterize the Bsn-mutant as a useful model for studying the effects of chronic changes to network activity.

U2 - 10.3389/fnsyn.2015.00018

DO - 10.3389/fnsyn.2015.00018

M3 - SCORING: Journal article

C2 - 26557085

VL - 7

SP - 18

JO - FRONT SYNAPTIC NEURO

JF - FRONT SYNAPTIC NEURO

SN - 1663-3563

ER -