Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis
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Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis. / Golde, Sabrina; Heine, Josephine; Pöttgen, Jana; Mantwill, Maron; Lau, Stephanie; Wingenfeld, Katja; Otte, Christian; Penner, Iris-Katharina; Engel, Andreas K; Heesen, Christoph; Stellmann, Jan-Patrick; Dziobek, Isabel; Finke, Carsten; Gold, Stefan M.
In: FRONT NEUROL, Vol. 11, 2020, p. 507.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis
AU - Golde, Sabrina
AU - Heine, Josephine
AU - Pöttgen, Jana
AU - Mantwill, Maron
AU - Lau, Stephanie
AU - Wingenfeld, Katja
AU - Otte, Christian
AU - Penner, Iris-Katharina
AU - Engel, Andreas K
AU - Heesen, Christoph
AU - Stellmann, Jan-Patrick
AU - Dziobek, Isabel
AU - Finke, Carsten
AU - Gold, Stefan M
N1 - Copyright © 2020 Golde, Heine, Pöttgen, Mantwill, Lau, Wingenfeld, Otte, Penner, Engel, Heesen, Stellmann, Dziobek, Finke and Gold.
PY - 2020
Y1 - 2020
N2 - Objective: Multiple sclerosis (MS) is characterized by impairments in basic cognitive functions such as information processing speed as well as in more complex, higher-order domains such as social cognition. However, as these deficits often co-occur, it has remained challenging to determine whether they have a specific pathological basis or are driven by shared biology. Methods: To identify neural signatures of social cognition deficits in MS, data were analyzed from n = 29 patients with relapsing-remitting MS and n = 29 healthy controls matched for age, sex, and education. We used neuropsychological assessments of information processing speed, attention, learning, working memory, and relevant aspects of social cognition (theory of mind, emotion recognition (ER), empathy) and employed neuroimaging of CNS networks using resting-state functional connectivity. Results: MS patients showed significant deficits in verbal learning and memory, as well as implicit ER. Performance in these domains was uncorrelated. Functional connectivity analysis identified a distinct network characterized by significant associations between poorer ER and lower connectivity of the fusiform gyrus (FFG) with the right lateral occipital cortex, which also showed lower connectivity in patients compared to controls. Moreover, while ER was correlated with MS symptoms such as fatigue and motor/sensory functioning on a behavioral level, FFG connectivity signatures of social cognition deficits showed no overlap with these symptoms. Conclusions: Our analyses identify distinct functional connectivity signatures of social cognition deficits in MS, indicating that these alterations may occur independently from those in other neuropsychological functions.
AB - Objective: Multiple sclerosis (MS) is characterized by impairments in basic cognitive functions such as information processing speed as well as in more complex, higher-order domains such as social cognition. However, as these deficits often co-occur, it has remained challenging to determine whether they have a specific pathological basis or are driven by shared biology. Methods: To identify neural signatures of social cognition deficits in MS, data were analyzed from n = 29 patients with relapsing-remitting MS and n = 29 healthy controls matched for age, sex, and education. We used neuropsychological assessments of information processing speed, attention, learning, working memory, and relevant aspects of social cognition (theory of mind, emotion recognition (ER), empathy) and employed neuroimaging of CNS networks using resting-state functional connectivity. Results: MS patients showed significant deficits in verbal learning and memory, as well as implicit ER. Performance in these domains was uncorrelated. Functional connectivity analysis identified a distinct network characterized by significant associations between poorer ER and lower connectivity of the fusiform gyrus (FFG) with the right lateral occipital cortex, which also showed lower connectivity in patients compared to controls. Moreover, while ER was correlated with MS symptoms such as fatigue and motor/sensory functioning on a behavioral level, FFG connectivity signatures of social cognition deficits showed no overlap with these symptoms. Conclusions: Our analyses identify distinct functional connectivity signatures of social cognition deficits in MS, indicating that these alterations may occur independently from those in other neuropsychological functions.
U2 - 10.3389/fneur.2020.00507
DO - 10.3389/fneur.2020.00507
M3 - SCORING: Journal article
C2 - 32670178
VL - 11
SP - 507
JO - FRONT NEUROL
JF - FRONT NEUROL
SN - 1664-2295
ER -
