Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation.
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Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation. / Golkar, Armita; Lonsdorf, Tina; Olsson, Andreas; Lindstrom, Kara M; Berrebi, Jonathan; Fransson, Peter; Schalling, Martin; Ingvar, Martin; Öhman, Arne.
In: PLOS ONE, Vol. 7, No. 11, 11, 2012, p. 48107.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation.
AU - Golkar, Armita
AU - Lonsdorf, Tina
AU - Olsson, Andreas
AU - Lindstrom, Kara M
AU - Berrebi, Jonathan
AU - Fransson, Peter
AU - Schalling, Martin
AU - Ingvar, Martin
AU - Öhman, Arne
PY - 2012
Y1 - 2012
N2 - The lateral prefrontal and orbitofrontal cortices have both been implicated in emotion regulation, but their distinct roles in regulation of negative emotion remain poorly understood. To address this issue we enrolled 58 participants in an fMRI study in which participants were instructed to reappraise both negative and neutral stimuli. This design allowed us to separately study activations reflecting cognitive processes associated with reappraisal in general and activations specifically related to reappraisal of negative emotion. Our results confirmed that both the dorsolateral prefrontal cortex (DLPFC) and the lateral orbitofrontal cortex (OFC) contribute to emotion regulation through reappraisal. However, activity in the DLPFC was related to reappraisal independently of whether negative or neutral stimuli were reappraised, whereas the lateral OFC was uniquely related to reappraisal of negative stimuli. We suggest that relative to the lateral OFC, the DLPFC serves a more general role in emotion regulation, perhaps by reflecting the cognitive demand that is inherent to the regulation task.
AB - The lateral prefrontal and orbitofrontal cortices have both been implicated in emotion regulation, but their distinct roles in regulation of negative emotion remain poorly understood. To address this issue we enrolled 58 participants in an fMRI study in which participants were instructed to reappraise both negative and neutral stimuli. This design allowed us to separately study activations reflecting cognitive processes associated with reappraisal in general and activations specifically related to reappraisal of negative emotion. Our results confirmed that both the dorsolateral prefrontal cortex (DLPFC) and the lateral orbitofrontal cortex (OFC) contribute to emotion regulation through reappraisal. However, activity in the DLPFC was related to reappraisal independently of whether negative or neutral stimuli were reappraised, whereas the lateral OFC was uniquely related to reappraisal of negative stimuli. We suggest that relative to the lateral OFC, the DLPFC serves a more general role in emotion regulation, perhaps by reflecting the cognitive demand that is inherent to the regulation task.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Photic Stimulation
KW - Magnetic Resonance Imaging
KW - Brain Mapping
KW - Emotions
KW - Prefrontal Cortex/physiology
KW - Amygdala/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Photic Stimulation
KW - Magnetic Resonance Imaging
KW - Brain Mapping
KW - Emotions
KW - Prefrontal Cortex/physiology
KW - Amygdala/physiology
U2 - 10.1371/journal.pone.0048107
DO - 10.1371/journal.pone.0048107
M3 - SCORING: Journal article
VL - 7
SP - 48107
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 11
M1 - 11
ER -
