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Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system

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Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system. / Kröger, Inga L; Düesberg, Mareike; May, Arne.

In: CEPHALALGIA, Vol. 36, No. 8, 01.07.2016, p. 790-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kröger, IL, Düesberg, M & May, A 2016, 'Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system', CEPHALALGIA, vol. 36, no. 8, pp. 790-9. https://doi.org/10.1177/0333102415612765

APA

Kröger, I. L., Düesberg, M., & May, A. (2016). Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system. CEPHALALGIA, 36(8), 790-9. https://doi.org/10.1177/0333102415612765

Vancouver

Kröger IL, Düesberg M, May A. Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system. CEPHALALGIA. 2016 Jul 1;36(8):790-9. https://doi.org/10.1177/0333102415612765

Bibtex

@article{7145555b20da462b846c5660c667f166,
title = "Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system",
abstract = "BACKGROUND: Individual differences in pain perception to a standardized nociceptive input are a well-known phenomenon within pain research. Brain structures known to play a crucial role in pain modulatory processes are the rostral/subgenual anterior cingulate cortex (sACC) as well as the periaqueductal gray (PAG), which belong to the endogenous antinociceptive system. However, the exact mechanisms possibly leading to this high level of variance in pain perception are still a matter of debate.METHODS: Pain perception within the trigemino-vascular system was investigated in 37 healthy volunteers using functional magnetic resonance imaging.RESULTS: Behavioral results show high levels of variance being inversely correlated to mean pain ratings as well as to an increase in BOLD signal intensity within the sACC. In addition, higher sACC activation was coupled with activation in the PAG the lower the level of intra-individual variance.CONCLUSION: This study gives first indications that coupled BOLD response within brain structures of the antinociceptive system seems to rather not code pain intensity within the trigemino-nociceptive system but the stability of volunteers' pain ratings. Intrinsic mechanisms may modulate the pain perception in the trigemino-vascular system, which is highly involved in headache disorders.",
author = "Kr{\"o}ger, {Inga L} and Mareike D{\"u}esberg and Arne May",
note = "{\textcopyright} International Headache Society 2015.",
year = "2016",
month = jul,
day = "1",
doi = "10.1177/0333102415612765",
language = "English",
volume = "36",
pages = "790--9",
journal = "CEPHALALGIA",
issn = "0333-1024",
publisher = "SAGE Publications",
number = "8",

}

RIS

TY - JOUR

T1 - Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system

AU - Kröger, Inga L

AU - Düesberg, Mareike

AU - May, Arne

N1 - © International Headache Society 2015.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - BACKGROUND: Individual differences in pain perception to a standardized nociceptive input are a well-known phenomenon within pain research. Brain structures known to play a crucial role in pain modulatory processes are the rostral/subgenual anterior cingulate cortex (sACC) as well as the periaqueductal gray (PAG), which belong to the endogenous antinociceptive system. However, the exact mechanisms possibly leading to this high level of variance in pain perception are still a matter of debate.METHODS: Pain perception within the trigemino-vascular system was investigated in 37 healthy volunteers using functional magnetic resonance imaging.RESULTS: Behavioral results show high levels of variance being inversely correlated to mean pain ratings as well as to an increase in BOLD signal intensity within the sACC. In addition, higher sACC activation was coupled with activation in the PAG the lower the level of intra-individual variance.CONCLUSION: This study gives first indications that coupled BOLD response within brain structures of the antinociceptive system seems to rather not code pain intensity within the trigemino-nociceptive system but the stability of volunteers' pain ratings. Intrinsic mechanisms may modulate the pain perception in the trigemino-vascular system, which is highly involved in headache disorders.

AB - BACKGROUND: Individual differences in pain perception to a standardized nociceptive input are a well-known phenomenon within pain research. Brain structures known to play a crucial role in pain modulatory processes are the rostral/subgenual anterior cingulate cortex (sACC) as well as the periaqueductal gray (PAG), which belong to the endogenous antinociceptive system. However, the exact mechanisms possibly leading to this high level of variance in pain perception are still a matter of debate.METHODS: Pain perception within the trigemino-vascular system was investigated in 37 healthy volunteers using functional magnetic resonance imaging.RESULTS: Behavioral results show high levels of variance being inversely correlated to mean pain ratings as well as to an increase in BOLD signal intensity within the sACC. In addition, higher sACC activation was coupled with activation in the PAG the lower the level of intra-individual variance.CONCLUSION: This study gives first indications that coupled BOLD response within brain structures of the antinociceptive system seems to rather not code pain intensity within the trigemino-nociceptive system but the stability of volunteers' pain ratings. Intrinsic mechanisms may modulate the pain perception in the trigemino-vascular system, which is highly involved in headache disorders.

U2 - 10.1177/0333102415612765

DO - 10.1177/0333102415612765

M3 - SCORING: Journal article

C2 - 26494855

VL - 36

SP - 790

EP - 799

JO - CEPHALALGIA

JF - CEPHALALGIA

SN - 0333-1024

IS - 8

ER -