Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brain
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Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brain. / Yacubian, Juliana; Gläscher, Jan; Schroeder, Katrin; Sommer-Blöchl, Tobias; Braus, Dieter F; Büchel, Christian.
In: J NEUROSCI, Vol. 26, No. 37, 13.09.2006, p. 9530-7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brain
AU - Yacubian, Juliana
AU - Gläscher, Jan
AU - Schroeder, Katrin
AU - Sommer-Blöchl, Tobias
AU - Braus, Dieter F
AU - Büchel, Christian
PY - 2006/9/13
Y1 - 2006/9/13
N2 - Midbrain dopaminergic neurons projecting to the ventral striatum code for reward magnitude and probability during reward anticipation and then indicate the difference between actual and predicted outcome. It has been questioned whether such a common system for the prediction and evaluation of reward exists in humans. Using functional magnetic resonance imaging and a guessing task in two large cohorts, we are able to confirm ventral striatal responses coding both reward probability and magnitude during anticipation, permitting the local computation of expected value (EV). However, the ventral striatum only represented the gain-related part of EV (EV+). At reward delivery, the same area shows a reward probability and magnitude-dependent prediction error signal, best modeled as the difference between actual outcome and EV+. In contrast, loss-related expected value (EV-) and the associated prediction error was represented in the amygdala. Thus, the ventral striatum and the amygdala distinctively process the value of a prediction and subsequently compute a prediction error for gains and losses, respectively. Therefore, a homeostatic balance of both systems might be important for generating adequate expectations under uncertainty. Prevalence of either part might render expectations more positive or negative, which could contribute to the pathophysiology of mood disorders like major depression.
AB - Midbrain dopaminergic neurons projecting to the ventral striatum code for reward magnitude and probability during reward anticipation and then indicate the difference between actual and predicted outcome. It has been questioned whether such a common system for the prediction and evaluation of reward exists in humans. Using functional magnetic resonance imaging and a guessing task in two large cohorts, we are able to confirm ventral striatal responses coding both reward probability and magnitude during anticipation, permitting the local computation of expected value (EV). However, the ventral striatum only represented the gain-related part of EV (EV+). At reward delivery, the same area shows a reward probability and magnitude-dependent prediction error signal, best modeled as the difference between actual outcome and EV+. In contrast, loss-related expected value (EV-) and the associated prediction error was represented in the amygdala. Thus, the ventral striatum and the amygdala distinctively process the value of a prediction and subsequently compute a prediction error for gains and losses, respectively. Therefore, a homeostatic balance of both systems might be important for generating adequate expectations under uncertainty. Prevalence of either part might render expectations more positive or negative, which could contribute to the pathophysiology of mood disorders like major depression.
KW - Adult
KW - Amygdala
KW - Basal Ganglia
KW - Brain Mapping
KW - Cognition
KW - Cohort Studies
KW - Dopamine
KW - Gambling
KW - Humans
KW - Judgment
KW - Magnetic Resonance Imaging
KW - Male
KW - Mood Disorders
KW - Neural Pathways
KW - Neuropsychological Tests
KW - Reward
KW - Thinking
KW - Ventral Tegmental Area
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1523/JNEUROSCI.2915-06.2006
DO - 10.1523/JNEUROSCI.2915-06.2006
M3 - SCORING: Journal article
C2 - 16971537
VL - 26
SP - 9530
EP - 9537
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 37
ER -