Disseminated Mycobacterium haemophilum infection in a renal transplant recipient

Silke R Brix; Christof Iking-Konert; Rolf A K Stahl; Ulrich Wenzel

doi:10.1136/bcr-2016-216042

Disseminated Mycobacterium haemophilum infection in a renal transplant recipient

Standard

Disseminated Mycobacterium haemophilum infection in a renal transplant recipient. / Brix, Silke R; Iking-Konert, Christof ; Stahl, Rolf A K ; Wenzel, Ulrich.

In: BMJ CASE REP, Vol. 2016, 31.10.2016.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brix, SR, Iking-Konert, C , Stahl, RAK & Wenzel, U 2016, 'Disseminated Mycobacterium haemophilum infection in a renal transplant recipient', BMJ CASE REP, vol. 2016. https://doi.org/10.1136/bcr-2016-216042

APA

Brix, S. R., Iking-Konert, C., Stahl, R. A. K., & Wenzel, U. (2016). Disseminated Mycobacterium haemophilum infection in a renal transplant recipient. BMJ CASE REP, 2016. https://doi.org/10.1136/bcr-2016-216042

Vancouver

Brix SR, Iking-Konert C , Stahl RAK , Wenzel U. Disseminated Mycobacterium haemophilum infection in a renal transplant recipient. BMJ CASE REP. 2016 Oct 31;2016. https://doi.org/10.1136/bcr-2016-216042

Bibtex

@article{f90545e7ba124e1f8de4ecb7face1f30,

title = "Disseminated Mycobacterium haemophilum infection in a renal transplant recipient",

abstract = "Opportunistic infections are a major concern in renal and transplant medicine. We present the case of a renal transplant recipient with a generalised Mycobacterium haemophilum infection after an increase in immunosuppressive therapy and treatment with a tumour necrosis factor-α (TNF-α) inhibitor. Infection involved skin and soft tissue, joints and bones, as well as the renal transplant with an interstitial nephritis. Rapid diagnosis using PCR and DNA sequencing allowed early appropriate treatment. Triple antibiotic therapy and reduction in immunosuppression resulted in a slow but sustained recovery. Immunosuppression causes severe opportunistic infections. TNF-α inhibitors are very effective and well tolerated but have an increased susceptibility to infections with mycobacteria. Mycobacterial infections represent a significant clinical risk to transplant recipients because of their aggressive clinical course and the need for complex toxic antibiotic treatments. In these patients, M. haemophilum is a cause of skin infections.",

keywords = "Adult, Antitubercular Agents, Biopsy, Humans, Immunocompromised Host, Immunosuppressive Agents, Kidney Function Tests, Kidney Transplantation, Male, Mycobacterium Infections, Mycobacterium haemophilum, Opportunistic Infections, Case Reports, Journal Article",

author = "Brix, {Silke R} and Christof Iking-Konert and Stahl, {Rolf A K} and Ulrich Wenzel",

note = "2016 BMJ Publishing Group Ltd.",

year = "2016",

month = oct,

day = "31",

doi = "10.1136/bcr-2016-216042",

language = "English",

volume = "2016",

journal = "BMJ CASE REP",

issn = "1757-790X",

publisher = "BMJ PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Disseminated Mycobacterium haemophilum infection in a renal transplant recipient

AU - Brix, Silke R

AU - Iking-Konert, Christof

AU - Stahl, Rolf A K

AU - Wenzel, Ulrich

N1 - 2016 BMJ Publishing Group Ltd.

PY - 2016/10/31

Y1 - 2016/10/31

N2 - Opportunistic infections are a major concern in renal and transplant medicine. We present the case of a renal transplant recipient with a generalised Mycobacterium haemophilum infection after an increase in immunosuppressive therapy and treatment with a tumour necrosis factor-α (TNF-α) inhibitor. Infection involved skin and soft tissue, joints and bones, as well as the renal transplant with an interstitial nephritis. Rapid diagnosis using PCR and DNA sequencing allowed early appropriate treatment. Triple antibiotic therapy and reduction in immunosuppression resulted in a slow but sustained recovery. Immunosuppression causes severe opportunistic infections. TNF-α inhibitors are very effective and well tolerated but have an increased susceptibility to infections with mycobacteria. Mycobacterial infections represent a significant clinical risk to transplant recipients because of their aggressive clinical course and the need for complex toxic antibiotic treatments. In these patients, M. haemophilum is a cause of skin infections.

AB - Opportunistic infections are a major concern in renal and transplant medicine. We present the case of a renal transplant recipient with a generalised Mycobacterium haemophilum infection after an increase in immunosuppressive therapy and treatment with a tumour necrosis factor-α (TNF-α) inhibitor. Infection involved skin and soft tissue, joints and bones, as well as the renal transplant with an interstitial nephritis. Rapid diagnosis using PCR and DNA sequencing allowed early appropriate treatment. Triple antibiotic therapy and reduction in immunosuppression resulted in a slow but sustained recovery. Immunosuppression causes severe opportunistic infections. TNF-α inhibitors are very effective and well tolerated but have an increased susceptibility to infections with mycobacteria. Mycobacterial infections represent a significant clinical risk to transplant recipients because of their aggressive clinical course and the need for complex toxic antibiotic treatments. In these patients, M. haemophilum is a cause of skin infections.

KW - Adult

KW - Antitubercular Agents

KW - Biopsy

KW - Humans

KW - Immunocompromised Host

KW - Immunosuppressive Agents

KW - Kidney Function Tests

KW - Kidney Transplantation

KW - Male

KW - Mycobacterium Infections

KW - Mycobacterium haemophilum

KW - Opportunistic Infections

KW - Case Reports

KW - Journal Article

U2 - 10.1136/bcr-2016-216042

DO - 10.1136/bcr-2016-216042

M3 - SCORING: Journal article

C2 - 27799227

VL - 2016

JO - BMJ CASE REP

JF - BMJ CASE REP

SN - 1757-790X

ER -