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Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias

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Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. / Jungen, Christiane; Scherschel, Katharina; Eickholt, Christian; Kuklik, Pawel; Klatt, Niklas; Bork, Nadja; Salzbrunn, Tim; Alken, Fares; Angendohr, Stephan; Klene, Christiane; Mester, Janos; Klöcker, Nikolaj; Veldkamp, Marieke W; Schumacher, Udo; Willems, Stephan; Nikolaev, Viacheslav O; Meyer, Christian.

In: NAT COMMUN, Vol. 8, 14155, 27.01.2017.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jungen, C, Scherschel, K, Eickholt, C, Kuklik, P, Klatt, N, Bork, N, Salzbrunn, T, Alken, F, Angendohr, S, Klene, C, Mester, J, Klöcker, N, Veldkamp, MW, Schumacher, U, Willems, S, Nikolaev, VO & Meyer, C 2017, 'Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias', NAT COMMUN, vol. 8, 14155. https://doi.org/10.1038/ncomms14155

APA

Jungen, C., Scherschel, K., Eickholt, C., Kuklik, P., Klatt, N., Bork, N., Salzbrunn, T., Alken, F., Angendohr, S., Klene, C., Mester, J., Klöcker, N., Veldkamp, M. W., Schumacher, U., Willems, S., Nikolaev, V. O., & Meyer, C. (2017). Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. NAT COMMUN, 8, [14155]. https://doi.org/10.1038/ncomms14155

Vancouver

Jungen C, Scherschel K, Eickholt C, Kuklik P, Klatt N, Bork N et al. Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. NAT COMMUN. 2017 Jan 27;8. 14155. https://doi.org/10.1038/ncomms14155

Bibtex

@article{8693304b89054de7aee30dca04924865,
title = "Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias",
abstract = "The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular electrophysiology is unclear. Here we show that cardiac cholinergic neurons modulate ventricular electrophysiology. Mechanical disruption or pharmacological blockade of parasympathetic innervation shortens ventricular refractory periods, increases the incidence of ventricular arrhythmia and decreases ventricular cAMP levels in murine hearts. Immunohistochemistry confirmed ventricular cholinergic innervation, revealing parasympathetic fibres running from the atria to the ventricles parallel to sympathetic fibres. In humans, catheter ablation of atrial fibrillation, which is accompanied by accidental parasympathetic and concomitant sympathetic denervation, raises the burden of premature ventricular complexes. In summary, our results demonstrate an influence of cardiac cholinergic neurons on the regulation of ventricular function and arrhythmogenesis.",
keywords = "Journal Article",
author = "Christiane Jungen and Katharina Scherschel and Christian Eickholt and Pawel Kuklik and Niklas Klatt and Nadja Bork and Tim Salzbrunn and Fares Alken and Stephan Angendohr and Christiane Klene and Janos Mester and Nikolaj Kl{\"o}cker and Veldkamp, {Marieke W} and Udo Schumacher and Stephan Willems and Nikolaev, {Viacheslav O} and Christian Meyer",
year = "2017",
month = jan,
day = "27",
doi = "10.1038/ncomms14155",
language = "English",
volume = "8",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias

AU - Jungen, Christiane

AU - Scherschel, Katharina

AU - Eickholt, Christian

AU - Kuklik, Pawel

AU - Klatt, Niklas

AU - Bork, Nadja

AU - Salzbrunn, Tim

AU - Alken, Fares

AU - Angendohr, Stephan

AU - Klene, Christiane

AU - Mester, Janos

AU - Klöcker, Nikolaj

AU - Veldkamp, Marieke W

AU - Schumacher, Udo

AU - Willems, Stephan

AU - Nikolaev, Viacheslav O

AU - Meyer, Christian

PY - 2017/1/27

Y1 - 2017/1/27

N2 - The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular electrophysiology is unclear. Here we show that cardiac cholinergic neurons modulate ventricular electrophysiology. Mechanical disruption or pharmacological blockade of parasympathetic innervation shortens ventricular refractory periods, increases the incidence of ventricular arrhythmia and decreases ventricular cAMP levels in murine hearts. Immunohistochemistry confirmed ventricular cholinergic innervation, revealing parasympathetic fibres running from the atria to the ventricles parallel to sympathetic fibres. In humans, catheter ablation of atrial fibrillation, which is accompanied by accidental parasympathetic and concomitant sympathetic denervation, raises the burden of premature ventricular complexes. In summary, our results demonstrate an influence of cardiac cholinergic neurons on the regulation of ventricular function and arrhythmogenesis.

AB - The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular electrophysiology is unclear. Here we show that cardiac cholinergic neurons modulate ventricular electrophysiology. Mechanical disruption or pharmacological blockade of parasympathetic innervation shortens ventricular refractory periods, increases the incidence of ventricular arrhythmia and decreases ventricular cAMP levels in murine hearts. Immunohistochemistry confirmed ventricular cholinergic innervation, revealing parasympathetic fibres running from the atria to the ventricles parallel to sympathetic fibres. In humans, catheter ablation of atrial fibrillation, which is accompanied by accidental parasympathetic and concomitant sympathetic denervation, raises the burden of premature ventricular complexes. In summary, our results demonstrate an influence of cardiac cholinergic neurons on the regulation of ventricular function and arrhythmogenesis.

KW - Journal Article

U2 - 10.1038/ncomms14155

DO - 10.1038/ncomms14155

M3 - SCORING: Journal article

C2 - 28128201

VL - 8

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

M1 - 14155

ER -