Disrupting the ipsilateral motor cortex interferes with training of a complex motor task in older adults
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Disrupting the ipsilateral motor cortex interferes with training of a complex motor task in older adults. / Zimerman, Máximo; Heise, Kirstin-Friederike; Gerloff, Christian; Cohen, Leonardo G; Hummel, Friedhelm.
In: CEREB CORTEX, Vol. 24, No. 4, 2014, p. 1030-1036.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Disrupting the ipsilateral motor cortex interferes with training of a complex motor task in older adults
AU - Zimerman, Máximo
AU - Heise, Kirstin-Friederike
AU - Gerloff, Christian
AU - Cohen, Leonardo G
AU - Hummel, Friedhelm
PY - 2014
Y1 - 2014
N2 - Performance of unimanual movements is associated with bihemispheric activity in the motor cortex in old adults. However, the causal functional role of the ipsilateral MC (iMC) for motor control is still not completely known. Here, the behavioral consequences of interference of the iMC during training of a complex motor skill were tested. Healthy old (58-85 years) and young volunteers (22-35 years) were tested in a double-blind, cross-over, sham-controlled design. Participants attended 2 different study arms with either cathodal transcranial direct current stimulation (ctDCS) or sham concurrent with training. Motor performance was evaluated before, during, 90 min, and 24 h after training. During training, a reduced slope of performance with ctDCS relative to sham was observed in old compared with young (F = 5.8, P = 0.02), with a decrease of correctly rehearsed sequences, an effect that was evident even after 2 consecutive retraining periods without intervention. Furthermore, the older the subject, the more prominent was the disruptive effect of ctDCS (R(2) = 0.50, P = 0.01). These data provide direct evidence for a causal functional link between the iMC and motor skill acquisition in old subjects pointing toward the concept that the recruitment of iMC in old is an adaptive process in response to age-related declines in motor functions.
AB - Performance of unimanual movements is associated with bihemispheric activity in the motor cortex in old adults. However, the causal functional role of the ipsilateral MC (iMC) for motor control is still not completely known. Here, the behavioral consequences of interference of the iMC during training of a complex motor skill were tested. Healthy old (58-85 years) and young volunteers (22-35 years) were tested in a double-blind, cross-over, sham-controlled design. Participants attended 2 different study arms with either cathodal transcranial direct current stimulation (ctDCS) or sham concurrent with training. Motor performance was evaluated before, during, 90 min, and 24 h after training. During training, a reduced slope of performance with ctDCS relative to sham was observed in old compared with young (F = 5.8, P = 0.02), with a decrease of correctly rehearsed sequences, an effect that was evident even after 2 consecutive retraining periods without intervention. Furthermore, the older the subject, the more prominent was the disruptive effect of ctDCS (R(2) = 0.50, P = 0.01). These data provide direct evidence for a causal functional link between the iMC and motor skill acquisition in old subjects pointing toward the concept that the recruitment of iMC in old is an adaptive process in response to age-related declines in motor functions.
U2 - 10.1093/cercor/bhs385
DO - 10.1093/cercor/bhs385
M3 - SCORING: Journal article
C2 - 23242199
VL - 24
SP - 1030
EP - 1036
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 4
ER -