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Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.

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Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. / Stoecklein, Nikolas H; Hosch, Stefan B; Bezler, Martin; Stern, Franziska; Hartmann, Claudia H; Vay, Christian; Siegmund, Annika; Scheunemann, Peter; Schurr, Paulus; Knoefel, Wolfram T; Verde Pablo, E; Reichelt, Uta; Erbersdobler, Andreas; Grau, Roger; Ullrich, Axel; Izbicki, Jakob R.; Klein, Christoph A.

In: CANCER CELL, Vol. 13, No. 5, 5, 2008, p. 441-453.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stoecklein, NH, Hosch, SB, Bezler, M, Stern, F, Hartmann, CH, Vay, C, Siegmund, A, Scheunemann, P, Schurr, P, Knoefel, WT, Verde Pablo, E, Reichelt, U, Erbersdobler, A, Grau, R, Ullrich, A, Izbicki, JR & Klein, CA 2008, 'Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.', CANCER CELL, vol. 13, no. 5, 5, pp. 441-453. <http://www.ncbi.nlm.nih.gov/pubmed/18455127?dopt=Citation>

APA

Stoecklein, N. H., Hosch, S. B., Bezler, M., Stern, F., Hartmann, C. H., Vay, C., Siegmund, A., Scheunemann, P., Schurr, P., Knoefel, W. T., Verde Pablo, E., Reichelt, U., Erbersdobler, A., Grau, R., Ullrich, A., Izbicki, J. R., & Klein, C. A. (2008). Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. CANCER CELL, 13(5), 441-453. [5]. http://www.ncbi.nlm.nih.gov/pubmed/18455127?dopt=Citation

Vancouver

Stoecklein NH, Hosch SB, Bezler M, Stern F, Hartmann CH, Vay C et al. Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. CANCER CELL. 2008;13(5):441-453. 5.

Bibtex

@article{e2a7d111498f41979913e1ce35664d62,
title = "Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.",
abstract = "The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To address this problem, we studied the precursor cells of metastases directly for the identification of prognostic and therapeutic markers and prospectively analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients. Whole-genome screening revealed that primary tumors and lymphatically and hematogenously disseminated cancer cells diverged for most genetic aberrations. However, we identified chromosome 17q12-21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites. Survival analysis demonstrated that HER2 gain in a single disseminated tumor cell but not in primary tumors conferred high risk for early death.",
author = "Stoecklein, {Nikolas H} and Hosch, {Stefan B} and Martin Bezler and Franziska Stern and Hartmann, {Claudia H} and Christian Vay and Annika Siegmund and Peter Scheunemann and Paulus Schurr and Knoefel, {Wolfram T} and {Verde Pablo}, E and Uta Reichelt and Andreas Erbersdobler and Roger Grau and Axel Ullrich and Izbicki, {Jakob R.} and Klein, {Christoph A}",
year = "2008",
language = "Deutsch",
volume = "13",
pages = "441--453",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.

AU - Stoecklein, Nikolas H

AU - Hosch, Stefan B

AU - Bezler, Martin

AU - Stern, Franziska

AU - Hartmann, Claudia H

AU - Vay, Christian

AU - Siegmund, Annika

AU - Scheunemann, Peter

AU - Schurr, Paulus

AU - Knoefel, Wolfram T

AU - Verde Pablo, E

AU - Reichelt, Uta

AU - Erbersdobler, Andreas

AU - Grau, Roger

AU - Ullrich, Axel

AU - Izbicki, Jakob R.

AU - Klein, Christoph A

PY - 2008

Y1 - 2008

N2 - The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To address this problem, we studied the precursor cells of metastases directly for the identification of prognostic and therapeutic markers and prospectively analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients. Whole-genome screening revealed that primary tumors and lymphatically and hematogenously disseminated cancer cells diverged for most genetic aberrations. However, we identified chromosome 17q12-21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites. Survival analysis demonstrated that HER2 gain in a single disseminated tumor cell but not in primary tumors conferred high risk for early death.

AB - The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To address this problem, we studied the precursor cells of metastases directly for the identification of prognostic and therapeutic markers and prospectively analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients. Whole-genome screening revealed that primary tumors and lymphatically and hematogenously disseminated cancer cells diverged for most genetic aberrations. However, we identified chromosome 17q12-21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites. Survival analysis demonstrated that HER2 gain in a single disseminated tumor cell but not in primary tumors conferred high risk for early death.

M3 - SCORING: Zeitschriftenaufsatz

VL - 13

SP - 441

EP - 453

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 5

M1 - 5

ER -