Direct evidence for spinal cord involvement in placebo analgesia.
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Direct evidence for spinal cord involvement in placebo analgesia. / Eippert, Falk; Finsterbusch, Jürgen; Bingel, Ulrike; Büchel, Christian.
In: SCIENCE, Vol. 326, No. 5951, 5951, 2009, p. 404.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Direct evidence for spinal cord involvement in placebo analgesia.
AU - Eippert, Falk
AU - Finsterbusch, Jürgen
AU - Bingel, Ulrike
AU - Büchel, Christian
PY - 2009
Y1 - 2009
N2 - Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.
AB - Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.
M3 - SCORING: Zeitschriftenaufsatz
VL - 326
SP - 404
JO - SCIENCE
JF - SCIENCE
SN - 0036-8075
IS - 5951
M1 - 5951
ER -