Direct evidence for spinal cord involvement in placebo analgesia.

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Direct evidence for spinal cord involvement in placebo analgesia. / Eippert, Falk; Finsterbusch, Jürgen; Bingel, Ulrike; Büchel, Christian.

In: SCIENCE, Vol. 326, No. 5951, 5951, 2009, p. 404.

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@article{111d1e91310847af96ba07cf9877fbe9,
title = "Direct evidence for spinal cord involvement in placebo analgesia.",
abstract = "Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.",
author = "Falk Eippert and J{\"u}rgen Finsterbusch and Ulrike Bingel and Christian B{\"u}chel",
year = "2009",
language = "Deutsch",
volume = "326",
pages = "404",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5951",

}

RIS

TY - JOUR

T1 - Direct evidence for spinal cord involvement in placebo analgesia.

AU - Eippert, Falk

AU - Finsterbusch, Jürgen

AU - Bingel, Ulrike

AU - Büchel, Christian

PY - 2009

Y1 - 2009

N2 - Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.

AB - Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.

M3 - SCORING: Zeitschriftenaufsatz

VL - 326

SP - 404

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 5951

M1 - 5951

ER -