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Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study

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Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study. / Lampart, Maurin; Rüegg, Marco; Jauslin, Andrea S; Simon, Noemi R; Zellweger, Núria; Eken, Ceylan; Tschudin-Sutter, Sarah; Bassetti, Stefano; Rentsch, Katharina M; Siegemund, Martin; Bingisser, Roland; Nickel, Christian H; Osswald, Stefan; Kuster, Gabriela M; Twerenbold, Raphael.

In: J CLIN MED, Vol. 10, No. 12, 2672, 17.06.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lampart, M, Rüegg, M, Jauslin, AS, Simon, NR, Zellweger, N, Eken, C, Tschudin-Sutter, S, Bassetti, S, Rentsch, KM, Siegemund, M, Bingisser, R, Nickel, CH, Osswald, S, Kuster, GM & Twerenbold, R 2021, 'Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study', J CLIN MED, vol. 10, no. 12, 2672. https://doi.org/10.3390/jcm10122672

APA

Lampart, M., Rüegg, M., Jauslin, A. S., Simon, N. R., Zellweger, N., Eken, C., Tschudin-Sutter, S., Bassetti, S., Rentsch, K. M., Siegemund, M., Bingisser, R., Nickel, C. H., Osswald, S., Kuster, G. M., & Twerenbold, R. (2021). Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study. J CLIN MED, 10(12), [2672]. https://doi.org/10.3390/jcm10122672

Vancouver

Lampart M, Rüegg M, Jauslin AS, Simon NR, Zellweger N, Eken C et al. Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study. J CLIN MED. 2021 Jun 17;10(12). 2672. https://doi.org/10.3390/jcm10122672

Bibtex

@article{0a4931e96c604c728123aa7b3e8aa105,
title = "Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study",
abstract = "Most studies investigating early risk predictors in coronavirus disease 19 (COVID-19) lacked comparison with controls. We aimed to assess and directly compare outcomes and risk predictors at time of emergency department (ED) presentation in COVID-19 and controls. Consecutive patients presenting to the ED with suspected COVID-19 were prospectively enrolled. COVID-19-patients were compared with (i) patients tested negative (overall controls) and (ii) patients tested negative, who had a respiratory infection (respiratory controls). Primary outcome was the composite of intensive care unit (ICU) admission and death at 30 days. Among 1081 consecutive cases, 191 (18%) were tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 890 (82%) were tested negative (overall controls), of which 323 (30%) had a respiratory infection (respiratory controls). Incidence of the composite outcome was significantly higher in COVID-19 (23%) as compared with the overall control group (10%, adjusted-HR 2.45 (95%CI, 1.61-3.74), p < 0.001) or the respiratory control group (10%, adjusted-HR 2.93 (95%CI, 1.66-5.17), p < 0.001). Blood oxygen saturation, age, high-sensitivity troponin, c-reactive protein, and lactate dehydrogenase were identified as the strongest predictors of poor outcome available at time of ED presentation in COVID-19 with highly comparable prognostic utility in overall and respiratory controls. In conclusion, patients presenting to the ED with COVID-19 have a worse outcome than controls, even after adjustment for differences in baseline characteristics. Most predictors of poor outcome in COVID-19 were not restricted to COVID-19, but of comparable prognostic utility in controls and therefore generalizable to unselected patients with suspected COVID-19.",
author = "Maurin Lampart and Marco R{\"u}egg and Jauslin, {Andrea S} and Simon, {Noemi R} and N{\'u}ria Zellweger and Ceylan Eken and Sarah Tschudin-Sutter and Stefano Bassetti and Rentsch, {Katharina M} and Martin Siegemund and Roland Bingisser and Nickel, {Christian H} and Stefan Osswald and Kuster, {Gabriela M} and Raphael Twerenbold",
year = "2021",
month = jun,
day = "17",
doi = "10.3390/jcm10122672",
language = "English",
volume = "10",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "12",

}

RIS

TY - JOUR

T1 - Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study

AU - Lampart, Maurin

AU - Rüegg, Marco

AU - Jauslin, Andrea S

AU - Simon, Noemi R

AU - Zellweger, Núria

AU - Eken, Ceylan

AU - Tschudin-Sutter, Sarah

AU - Bassetti, Stefano

AU - Rentsch, Katharina M

AU - Siegemund, Martin

AU - Bingisser, Roland

AU - Nickel, Christian H

AU - Osswald, Stefan

AU - Kuster, Gabriela M

AU - Twerenbold, Raphael

PY - 2021/6/17

Y1 - 2021/6/17

N2 - Most studies investigating early risk predictors in coronavirus disease 19 (COVID-19) lacked comparison with controls. We aimed to assess and directly compare outcomes and risk predictors at time of emergency department (ED) presentation in COVID-19 and controls. Consecutive patients presenting to the ED with suspected COVID-19 were prospectively enrolled. COVID-19-patients were compared with (i) patients tested negative (overall controls) and (ii) patients tested negative, who had a respiratory infection (respiratory controls). Primary outcome was the composite of intensive care unit (ICU) admission and death at 30 days. Among 1081 consecutive cases, 191 (18%) were tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 890 (82%) were tested negative (overall controls), of which 323 (30%) had a respiratory infection (respiratory controls). Incidence of the composite outcome was significantly higher in COVID-19 (23%) as compared with the overall control group (10%, adjusted-HR 2.45 (95%CI, 1.61-3.74), p < 0.001) or the respiratory control group (10%, adjusted-HR 2.93 (95%CI, 1.66-5.17), p < 0.001). Blood oxygen saturation, age, high-sensitivity troponin, c-reactive protein, and lactate dehydrogenase were identified as the strongest predictors of poor outcome available at time of ED presentation in COVID-19 with highly comparable prognostic utility in overall and respiratory controls. In conclusion, patients presenting to the ED with COVID-19 have a worse outcome than controls, even after adjustment for differences in baseline characteristics. Most predictors of poor outcome in COVID-19 were not restricted to COVID-19, but of comparable prognostic utility in controls and therefore generalizable to unselected patients with suspected COVID-19.

AB - Most studies investigating early risk predictors in coronavirus disease 19 (COVID-19) lacked comparison with controls. We aimed to assess and directly compare outcomes and risk predictors at time of emergency department (ED) presentation in COVID-19 and controls. Consecutive patients presenting to the ED with suspected COVID-19 were prospectively enrolled. COVID-19-patients were compared with (i) patients tested negative (overall controls) and (ii) patients tested negative, who had a respiratory infection (respiratory controls). Primary outcome was the composite of intensive care unit (ICU) admission and death at 30 days. Among 1081 consecutive cases, 191 (18%) were tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 890 (82%) were tested negative (overall controls), of which 323 (30%) had a respiratory infection (respiratory controls). Incidence of the composite outcome was significantly higher in COVID-19 (23%) as compared with the overall control group (10%, adjusted-HR 2.45 (95%CI, 1.61-3.74), p < 0.001) or the respiratory control group (10%, adjusted-HR 2.93 (95%CI, 1.66-5.17), p < 0.001). Blood oxygen saturation, age, high-sensitivity troponin, c-reactive protein, and lactate dehydrogenase were identified as the strongest predictors of poor outcome available at time of ED presentation in COVID-19 with highly comparable prognostic utility in overall and respiratory controls. In conclusion, patients presenting to the ED with COVID-19 have a worse outcome than controls, even after adjustment for differences in baseline characteristics. Most predictors of poor outcome in COVID-19 were not restricted to COVID-19, but of comparable prognostic utility in controls and therefore generalizable to unselected patients with suspected COVID-19.

U2 - 10.3390/jcm10122672

DO - 10.3390/jcm10122672

M3 - SCORING: Journal article

C2 - 34204453

VL - 10

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 12

M1 - 2672

ER -