Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations

Julia Bär; Yannes Popp; Michael Bucher; Marina Mikhaylova

doi:10.1016/j.bbamcr.2022.119241

Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations

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Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations. / Bär, Julia; Popp, Yannes; Bucher, Michael; Mikhaylova, Marina.

In: BBA-MOL CELL RES, Vol. 1869, No. 6, 119241, 06.2022.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Bär, J, Popp, Y, Bucher, M & Mikhaylova, M 2022, 'Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations', BBA-MOL CELL RES, vol. 1869, no. 6, 119241. https://doi.org/10.1016/j.bbamcr.2022.119241

APA

Bär, J., Popp, Y., Bucher, M., & Mikhaylova, M. (2022). Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations. BBA-MOL CELL RES, 1869(6), [119241]. https://doi.org/10.1016/j.bbamcr.2022.119241

Vancouver

Bär J, Popp Y, Bucher M, Mikhaylova M. Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations. BBA-MOL CELL RES. 2022 Jun;1869(6). 119241. https://doi.org/10.1016/j.bbamcr.2022.119241

Bibtex

@article{04779af04bf84e6db8ecc2e107faaaf7,

title = "Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations",

abstract = "Microtubules (MTs) mediate various cellular functions such as structural support, chromosome segregation, and intracellular transport. To achieve this, the pivotal properties of MTs have to be changeable and tightly controlled. This is enabled by a high variety of tubulin posttranslational modifications, which influence MT properties directly, via altering the MT lattice structurally, or indirectly by changing MT interaction partners. Here, the distinction between these direct and indirect effects of MT PTMs are exemplified by acetylation of the luminal α-tubulin K40 resulting in decreased rigidity of MTs, and by MT detyrosination which decreases interaction with depolymerizing proteins, thus causing more stable MTs. We discuss how these PTMs are reversed and regulated, e.g. on the level of enzyme transcription, localization, and activity via various signalling pathways including the conventional calcium-dependent proteases calpains and how advances in microscopy techniques and development of live-sensors facilitate the understanding of MT PTM interaction and effects.",

author = "Julia B{\"a}r and Yannes Popp and Michael Bucher and Marina Mikhaylova",

year = "2022",

month = jun,

doi = "10.1016/j.bbamcr.2022.119241",

language = "English",

volume = "1869",

journal = "BBA-MOL CELL RES",

issn = "0167-4889",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations

AU - Bär, Julia

AU - Popp, Yannes

AU - Bucher, Michael

AU - Mikhaylova, Marina

PY - 2022/6

Y1 - 2022/6

N2 - Microtubules (MTs) mediate various cellular functions such as structural support, chromosome segregation, and intracellular transport. To achieve this, the pivotal properties of MTs have to be changeable and tightly controlled. This is enabled by a high variety of tubulin posttranslational modifications, which influence MT properties directly, via altering the MT lattice structurally, or indirectly by changing MT interaction partners. Here, the distinction between these direct and indirect effects of MT PTMs are exemplified by acetylation of the luminal α-tubulin K40 resulting in decreased rigidity of MTs, and by MT detyrosination which decreases interaction with depolymerizing proteins, thus causing more stable MTs. We discuss how these PTMs are reversed and regulated, e.g. on the level of enzyme transcription, localization, and activity via various signalling pathways including the conventional calcium-dependent proteases calpains and how advances in microscopy techniques and development of live-sensors facilitate the understanding of MT PTM interaction and effects.

AB - Microtubules (MTs) mediate various cellular functions such as structural support, chromosome segregation, and intracellular transport. To achieve this, the pivotal properties of MTs have to be changeable and tightly controlled. This is enabled by a high variety of tubulin posttranslational modifications, which influence MT properties directly, via altering the MT lattice structurally, or indirectly by changing MT interaction partners. Here, the distinction between these direct and indirect effects of MT PTMs are exemplified by acetylation of the luminal α-tubulin K40 resulting in decreased rigidity of MTs, and by MT detyrosination which decreases interaction with depolymerizing proteins, thus causing more stable MTs. We discuss how these PTMs are reversed and regulated, e.g. on the level of enzyme transcription, localization, and activity via various signalling pathways including the conventional calcium-dependent proteases calpains and how advances in microscopy techniques and development of live-sensors facilitate the understanding of MT PTM interaction and effects.

U2 - 10.1016/j.bbamcr.2022.119241

DO - 10.1016/j.bbamcr.2022.119241

M3 - SCORING: Review article

C2 - 35181405

VL - 1869

JO - BBA-MOL CELL RES

JF - BBA-MOL CELL RES

SN - 0167-4889

IS - 6

M1 - 119241

ER -