Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses.

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Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses. / Koch, H M; Christensen, K L Y; Harth, Volker; Lorber, M; Brüning, T.

In: ARCH TOXICOL, Vol. 86, No. 12, 12, 2012, p. 1829-1839.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{16e1abcba6f2435683b262a73902f3c9,
title = "Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses.",
abstract = "An individual (male, 36 years, 87 kg) ingested two separate doses of di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) at a rate of ~60 ?g/kg. Key monoester and oxidized metabolites were identified and quantified in urine continuously collected until 48 h post-dose. For both DnBP and DiBP, the majority of the dose was excreted in the first 24 h (92.2 % of DnBP, 90.3 % of DiBP), while only",
keywords = "Adult, Humans, Male, Creatinine/blood, Indicators and Reagents, Oxidation-Reduction, Half-Life, Dibutyl Phthalate/*analogs & derivatives/*metabolism/pharmacokinetics, Environmental Monitoring, Plasticizers/*metabolism/pharmacokinetics, Adult, Humans, Male, Creatinine/blood, Indicators and Reagents, Oxidation-Reduction, Half-Life, Dibutyl Phthalate/*analogs & derivatives/*metabolism/pharmacokinetics, Environmental Monitoring, Plasticizers/*metabolism/pharmacokinetics",
author = "Koch, {H M} and Christensen, {K L Y} and Volker Harth and M Lorber and T Br{\"u}ning",
year = "2012",
language = "English",
volume = "86",
pages = "1829--1839",
journal = "ARCH TOXICOL",
issn = "0340-5761",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses.

AU - Koch, H M

AU - Christensen, K L Y

AU - Harth, Volker

AU - Lorber, M

AU - Brüning, T

PY - 2012

Y1 - 2012

N2 - An individual (male, 36 years, 87 kg) ingested two separate doses of di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) at a rate of ~60 ?g/kg. Key monoester and oxidized metabolites were identified and quantified in urine continuously collected until 48 h post-dose. For both DnBP and DiBP, the majority of the dose was excreted in the first 24 h (92.2 % of DnBP, 90.3 % of DiBP), while only

AB - An individual (male, 36 years, 87 kg) ingested two separate doses of di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) at a rate of ~60 ?g/kg. Key monoester and oxidized metabolites were identified and quantified in urine continuously collected until 48 h post-dose. For both DnBP and DiBP, the majority of the dose was excreted in the first 24 h (92.2 % of DnBP, 90.3 % of DiBP), while only

KW - Adult

KW - Humans

KW - Male

KW - Creatinine/blood

KW - Indicators and Reagents

KW - Oxidation-Reduction

KW - Half-Life

KW - Dibutyl Phthalate/analogs & derivatives/metabolism/pharmacokinetics

KW - Environmental Monitoring

KW - Plasticizers/metabolism/pharmacokinetics

KW - Adult

KW - Humans

KW - Male

KW - Creatinine/blood

KW - Indicators and Reagents

KW - Oxidation-Reduction

KW - Half-Life

KW - Dibutyl Phthalate/analogs & derivatives/metabolism/pharmacokinetics

KW - Environmental Monitoring

KW - Plasticizers/metabolism/pharmacokinetics

M3 - SCORING: Journal article

VL - 86

SP - 1829

EP - 1839

JO - ARCH TOXICOL

JF - ARCH TOXICOL

SN - 0340-5761

IS - 12

M1 - 12

ER -