Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses.
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Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses. / Koch, H M; Christensen, K L Y; Harth, Volker; Lorber, M; Brüning, T.
In: ARCH TOXICOL, Vol. 86, No. 12, 12, 2012, p. 1829-1839.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses.
AU - Koch, H M
AU - Christensen, K L Y
AU - Harth, Volker
AU - Lorber, M
AU - Brüning, T
PY - 2012
Y1 - 2012
N2 - An individual (male, 36 years, 87 kg) ingested two separate doses of di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) at a rate of ~60 ?g/kg. Key monoester and oxidized metabolites were identified and quantified in urine continuously collected until 48 h post-dose. For both DnBP and DiBP, the majority of the dose was excreted in the first 24 h (92.2 % of DnBP, 90.3 % of DiBP), while only
AB - An individual (male, 36 years, 87 kg) ingested two separate doses of di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) at a rate of ~60 ?g/kg. Key monoester and oxidized metabolites were identified and quantified in urine continuously collected until 48 h post-dose. For both DnBP and DiBP, the majority of the dose was excreted in the first 24 h (92.2 % of DnBP, 90.3 % of DiBP), while only
KW - Adult
KW - Humans
KW - Male
KW - Creatinine/blood
KW - Indicators and Reagents
KW - Oxidation-Reduction
KW - Half-Life
KW - Dibutyl Phthalate/analogs & derivatives/metabolism/pharmacokinetics
KW - Environmental Monitoring
KW - Plasticizers/metabolism/pharmacokinetics
KW - Adult
KW - Humans
KW - Male
KW - Creatinine/blood
KW - Indicators and Reagents
KW - Oxidation-Reduction
KW - Half-Life
KW - Dibutyl Phthalate/analogs & derivatives/metabolism/pharmacokinetics
KW - Environmental Monitoring
KW - Plasticizers/metabolism/pharmacokinetics
M3 - SCORING: Journal article
VL - 86
SP - 1829
EP - 1839
JO - ARCH TOXICOL
JF - ARCH TOXICOL
SN - 0340-5761
IS - 12
M1 - 12
ER -