Diffusion-weighted imaging of the healthy pancreas: ADC values are age and gender dependent
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Diffusion-weighted imaging of the healthy pancreas: ADC values are age and gender dependent. / Herrmann, Jochen; Schoennagel, Bjoern P; Roesch, Magdalena; Busch, Jasmin D; Derlin, Thorsten; Doh, Laura K; Petersen, Kay U; Graessner, Joachim; Adam, Gerhard; Habermann, Christian R.
In: J MAGN RESON IMAGING, Vol. 37, No. 4, 4, 2013, p. 886-891.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Diffusion-weighted imaging of the healthy pancreas: ADC values are age and gender dependent
AU - Herrmann, Jochen
AU - Schoennagel, Bjoern P
AU - Roesch, Magdalena
AU - Busch, Jasmin D
AU - Derlin, Thorsten
AU - Doh, Laura K
AU - Petersen, Kay U
AU - Graessner, Joachim
AU - Adam, Gerhard
AU - Habermann, Christian R
N1 - Copyright © 2012 Wiley Periodicals, Inc.
PY - 2013
Y1 - 2013
N2 - PURPOSE: To investigate the healthy pancreas with diffusion-weighted imaging (DWI) for characterization of age and gender-related differences in apparent diffusion coefficient (ADC) values.MATERIALS AND METHODS: Sixty six volunteers were prospectively enrolled (33 male, 33 female; range 1.4 to 83.7 years of age) and echo-planar DWI of the pancreas was performed. ADC values were measured in the pancreas head, body, and tail using a pixel-by-pixel approach. Effects of age and gender on ADC values were analyzed using a two-factorial multivariate analysis of variance (MANOVA).RESULTS: ADC values correlated inversely with the age of the volunteers. The mean global pancreatic ADC values (× 10(-3) mm(2)/s) in the age groups 0-20 years, 21-40 years, and > 40 years were 1.18 ± 0.19, 1.07 ± 0.13, and 0.99 ± 0.18, respectively. Female individuals had higher mean global ADC values than male (1.13 ± 0.14 versus 1.02 ± 0.18 × 10(-3) mm(2)/s). MANOVA showed significant effects of age (P value 0.022, eta(2) = 0.13) and gender (P value 0.001, eta(2) = 0.28) on ADC values.CONCLUSION: Pancreatic ADC values decline with ageing and show significant gender differences with higher mean values in females. The awareness of baseline values adjusted to age and gender will be important for correct interpretation of individual cases and design of future studies.
AB - PURPOSE: To investigate the healthy pancreas with diffusion-weighted imaging (DWI) for characterization of age and gender-related differences in apparent diffusion coefficient (ADC) values.MATERIALS AND METHODS: Sixty six volunteers were prospectively enrolled (33 male, 33 female; range 1.4 to 83.7 years of age) and echo-planar DWI of the pancreas was performed. ADC values were measured in the pancreas head, body, and tail using a pixel-by-pixel approach. Effects of age and gender on ADC values were analyzed using a two-factorial multivariate analysis of variance (MANOVA).RESULTS: ADC values correlated inversely with the age of the volunteers. The mean global pancreatic ADC values (× 10(-3) mm(2)/s) in the age groups 0-20 years, 21-40 years, and > 40 years were 1.18 ± 0.19, 1.07 ± 0.13, and 0.99 ± 0.18, respectively. Female individuals had higher mean global ADC values than male (1.13 ± 0.14 versus 1.02 ± 0.18 × 10(-3) mm(2)/s). MANOVA showed significant effects of age (P value 0.022, eta(2) = 0.13) and gender (P value 0.001, eta(2) = 0.28) on ADC values.CONCLUSION: Pancreatic ADC values decline with ageing and show significant gender differences with higher mean values in females. The awareness of baseline values adjusted to age and gender will be important for correct interpretation of individual cases and design of future studies.
U2 - 10.1002/jmri.23871
DO - 10.1002/jmri.23871
M3 - SCORING: Journal article
C2 - 23086728
VL - 37
SP - 886
EP - 891
JO - J MAGN RESON IMAGING
JF - J MAGN RESON IMAGING
SN - 1053-1807
IS - 4
M1 - 4
ER -
