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Diffusion Tensor Imaging of Dystrophic Skeletal Muscle: Comparison of Two Segmentation Methods Adapted to Chemical-shift-encoded Water-fat MRI

Standard

Diffusion Tensor Imaging of Dystrophic Skeletal Muscle: Comparison of Two Segmentation Methods Adapted to Chemical-shift-encoded Water-fat MRI. / Keller, S; Wang, Z J; Aigner, A; Kim, A C; Golsari, A; Kooijman, H; Adam, G; Yamamura, J.

In: CLIN NEURORADIOL, Vol. 29, No. 2, 06.2019, p. 231-242.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Keller, S, Wang, ZJ, Aigner, A, Kim, AC, Golsari, A, Kooijman, H, Adam, G & Yamamura, J 2019, 'Diffusion Tensor Imaging of Dystrophic Skeletal Muscle: Comparison of Two Segmentation Methods Adapted to Chemical-shift-encoded Water-fat MRI', CLIN NEURORADIOL, vol. 29, no. 2, pp. 231-242. https://doi.org/10.1007/s00062-018-0667-3

APA

Keller, S., Wang, Z. J., Aigner, A., Kim, A. C., Golsari, A., Kooijman, H., Adam, G., & Yamamura, J. (2019). Diffusion Tensor Imaging of Dystrophic Skeletal Muscle: Comparison of Two Segmentation Methods Adapted to Chemical-shift-encoded Water-fat MRI. CLIN NEURORADIOL, 29(2), 231-242. https://doi.org/10.1007/s00062-018-0667-3

Vancouver

Keller S, Wang ZJ, Aigner A, Kim AC, Golsari A, Kooijman H et al. Diffusion Tensor Imaging of Dystrophic Skeletal Muscle: Comparison of Two Segmentation Methods Adapted to Chemical-shift-encoded Water-fat MRI. CLIN NEURORADIOL. 2019 Jun;29(2):231-242. https://doi.org/10.1007/s00062-018-0667-3

Bibtex

@article{9fde824698d94dd2981d801d43ae3848,
title = "Diffusion Tensor Imaging of Dystrophic Skeletal Muscle: Comparison of Two Segmentation Methods Adapted to Chemical-shift-encoded Water-fat MRI",
abstract = "PURPOSE: To compare the influence of two different regions of interest (ROIs) on diffusion tensor metrics in dystrophic thigh muscles using a custom-made (whole muscle) ROI including and a selective ROI excluding areas of fatty replacement.METHODS: Diffusion tensor imaging (DTI) and chemical-shift-encoded water-fat magnetic resonance imaging (MRI) of the thigh was conducted on a 3-Tesla system in 15 cases with muscular dystrophy and controls. The ROIs were chosen according to patterns of fatty replacement on co-registered axial DTI and gradient echo sequence (GRE) images. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), fiber track length (FTL), and muscle fat fractions (MFF) were compared between both ROI segmentations. These comparisons, muscle-specific correlation coefficients, and the influence of ROI localization on tensor metrics were derived based on linear mixed effects regression models.RESULTS: In the cases a high correlation was observed for ADC and FA with MFF using a custom ROI. The correlation was weaker but still significant with a selective ROI method. Using the custom ROI, FTL correlated significantly with MFF in 3 out of 4 muscles (r ≤ -0.51). A correlation was not found for the selective ROI method. Interaction analysis revealed that the association of ADC and FA with MFF was not significantly influenced by the ROI localization. For FTL the ROI localization significantly reduced the negative association with MFF.CONCLUSION: The DTI metrics and FTL of custom ROI segmentation are significantly influenced by MFF. Contrary to ADC and FA, the effect of MFF on FTL is significantly reduced when applying selective ROI segmentation, which could therefore be a better option for MR tractography.",
keywords = "Journal Article",
author = "S Keller and Wang, {Z J} and A Aigner and Kim, {A C} and A Golsari and H Kooijman and G Adam and J Yamamura",
year = "2019",
month = jun,
doi = "10.1007/s00062-018-0667-3",
language = "English",
volume = "29",
pages = "231--242",
journal = "CLIN NEURORADIOL",
issn = "1869-1439",
publisher = "Springer Heidelberg",
number = "2",

}

RIS

TY - JOUR

T1 - Diffusion Tensor Imaging of Dystrophic Skeletal Muscle: Comparison of Two Segmentation Methods Adapted to Chemical-shift-encoded Water-fat MRI

AU - Keller, S

AU - Wang, Z J

AU - Aigner, A

AU - Kim, A C

AU - Golsari, A

AU - Kooijman, H

AU - Adam, G

AU - Yamamura, J

PY - 2019/6

Y1 - 2019/6

N2 - PURPOSE: To compare the influence of two different regions of interest (ROIs) on diffusion tensor metrics in dystrophic thigh muscles using a custom-made (whole muscle) ROI including and a selective ROI excluding areas of fatty replacement.METHODS: Diffusion tensor imaging (DTI) and chemical-shift-encoded water-fat magnetic resonance imaging (MRI) of the thigh was conducted on a 3-Tesla system in 15 cases with muscular dystrophy and controls. The ROIs were chosen according to patterns of fatty replacement on co-registered axial DTI and gradient echo sequence (GRE) images. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), fiber track length (FTL), and muscle fat fractions (MFF) were compared between both ROI segmentations. These comparisons, muscle-specific correlation coefficients, and the influence of ROI localization on tensor metrics were derived based on linear mixed effects regression models.RESULTS: In the cases a high correlation was observed for ADC and FA with MFF using a custom ROI. The correlation was weaker but still significant with a selective ROI method. Using the custom ROI, FTL correlated significantly with MFF in 3 out of 4 muscles (r ≤ -0.51). A correlation was not found for the selective ROI method. Interaction analysis revealed that the association of ADC and FA with MFF was not significantly influenced by the ROI localization. For FTL the ROI localization significantly reduced the negative association with MFF.CONCLUSION: The DTI metrics and FTL of custom ROI segmentation are significantly influenced by MFF. Contrary to ADC and FA, the effect of MFF on FTL is significantly reduced when applying selective ROI segmentation, which could therefore be a better option for MR tractography.

AB - PURPOSE: To compare the influence of two different regions of interest (ROIs) on diffusion tensor metrics in dystrophic thigh muscles using a custom-made (whole muscle) ROI including and a selective ROI excluding areas of fatty replacement.METHODS: Diffusion tensor imaging (DTI) and chemical-shift-encoded water-fat magnetic resonance imaging (MRI) of the thigh was conducted on a 3-Tesla system in 15 cases with muscular dystrophy and controls. The ROIs were chosen according to patterns of fatty replacement on co-registered axial DTI and gradient echo sequence (GRE) images. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), fiber track length (FTL), and muscle fat fractions (MFF) were compared between both ROI segmentations. These comparisons, muscle-specific correlation coefficients, and the influence of ROI localization on tensor metrics were derived based on linear mixed effects regression models.RESULTS: In the cases a high correlation was observed for ADC and FA with MFF using a custom ROI. The correlation was weaker but still significant with a selective ROI method. Using the custom ROI, FTL correlated significantly with MFF in 3 out of 4 muscles (r ≤ -0.51). A correlation was not found for the selective ROI method. Interaction analysis revealed that the association of ADC and FA with MFF was not significantly influenced by the ROI localization. For FTL the ROI localization significantly reduced the negative association with MFF.CONCLUSION: The DTI metrics and FTL of custom ROI segmentation are significantly influenced by MFF. Contrary to ADC and FA, the effect of MFF on FTL is significantly reduced when applying selective ROI segmentation, which could therefore be a better option for MR tractography.

KW - Journal Article

U2 - 10.1007/s00062-018-0667-3

DO - 10.1007/s00062-018-0667-3

M3 - SCORING: Journal article

C2 - 29392347

VL - 29

SP - 231

EP - 242

JO - CLIN NEURORADIOL

JF - CLIN NEURORADIOL

SN - 1869-1439

IS - 2

ER -