Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis.
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Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis. / Jacob, S; Finsterbusch, Jürgen; Weishaupt, J H; Khorram-Sefat, D; Frahm, J; Ehrenreich, H.
In: NEURORADIOLOGY, Vol. 45, No. 9, 9, 2003, p. 598-600.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis.
AU - Jacob, S
AU - Finsterbusch, Jürgen
AU - Weishaupt, J H
AU - Khorram-Sefat, D
AU - Frahm, J
AU - Ehrenreich, H
PY - 2003
Y1 - 2003
N2 - Amyotrophic lateral sclerosis (ALS) is a predominantly clinical and electromyographic diagnosis. Conventional MRI reveals atrophy of the motor system, particularly the pyramidal tract, in the advanced stages but does not provide a sensitive measure of disease progression. Three patients with different principal symptoms of ALS, i.e., with predominant involvement of the upper (UMN) or lower (UMN) motor neurons, or bulbar disease, respectively, underwent serial clinical examination including lung function tests, conventional MRI, and diffusion tensor imaging (DTI). MRI demonstrated changes in of the pyramidal tract without measurable variation on follow-up. The patient with UMN involvement showed remarkable progressive loss of diffusion anisotropy in the pyramidal tract. DTI might be useful, together with clinical follow-up, as an objective morphological marker in therapeutic trials.
AB - Amyotrophic lateral sclerosis (ALS) is a predominantly clinical and electromyographic diagnosis. Conventional MRI reveals atrophy of the motor system, particularly the pyramidal tract, in the advanced stages but does not provide a sensitive measure of disease progression. Three patients with different principal symptoms of ALS, i.e., with predominant involvement of the upper (UMN) or lower (UMN) motor neurons, or bulbar disease, respectively, underwent serial clinical examination including lung function tests, conventional MRI, and diffusion tensor imaging (DTI). MRI demonstrated changes in of the pyramidal tract without measurable variation on follow-up. The patient with UMN involvement showed remarkable progressive loss of diffusion anisotropy in the pyramidal tract. DTI might be useful, together with clinical follow-up, as an objective morphological marker in therapeutic trials.
M3 - SCORING: Zeitschriftenaufsatz
VL - 45
SP - 598
EP - 600
JO - NEURORADIOLOGY
JF - NEURORADIOLOGY
SN - 0028-3940
IS - 9
M1 - 9
ER -
