Diffusion tensor imaging changes in patients with glioma-associated seizures
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Diffusion tensor imaging changes in patients with glioma-associated seizures. / Mader, Marius Marc-Daniel; Deuter, Daniel; Sauvigny, Thomas; Borchert, Patrick; Faizy, Tobias D.; Bester, Maxim; Westphal, Manfred; Rosengarth, Katharina; Schmidt, Nils O.; Sedlacik, Jan; Dührsen, Lasse.
In: J NEURO-ONCOL, Vol. 160, No. 2, 07.11.2022, p. 311-320.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Diffusion tensor imaging changes in patients with glioma-associated seizures
AU - Mader, Marius Marc-Daniel
AU - Deuter, Daniel
AU - Sauvigny, Thomas
AU - Borchert, Patrick
AU - Faizy, Tobias D.
AU - Bester, Maxim
AU - Westphal, Manfred
AU - Rosengarth, Katharina
AU - Schmidt, Nils O.
AU - Sedlacik, Jan
AU - Dührsen, Lasse
N1 - © 2022. The Author(s).
PY - 2022/11/7
Y1 - 2022/11/7
N2 - INTRODUCTION: Structural white matter changes associated with certain epilepsy subtypes have been demonstrated using diffusion tensor imaging (DTI). This observational study aims to identify potential water diffusion abnormalities in glioma patients with associated seizures.METHODS: Two cohorts from two centers were analyzed independently: (A) Prospectively recruited patients diagnosed with glioma who received preoperative DTI to measure mean diffusivity (MD) and fractional anisotropy (FA) in regions-of-interest (ROIs) including the marginal tumor zone (TU), adjacent peritumoral white matter as well as distant ipsilateral and contralateral white matter and cortex. Data were compared between patients with and without seizures and tested for statistical significance. (B) A retrospective cohort using an alternative technical approach sampling ROIs in contrast enhancement, necrosis, non-enhancing tumor, marginal non-enhancing tumor zone, peritumoral tissue, edema and non-tumorous tissue.RESULTS: (A) The prospective study cohort consisted of 23 patients with 12 (52.2%) presenting with a history of seizures. There were no significant seizure-associated differences in MD or FA for non-tumor white matter or cortical areas. MD-TU was significantly lower in patients with seizures (p = 0.005). (B) In the retrospective cohort consisting of 46 patients with a seizure incidence of 50.0%, significantly decreased normalized values of MD were observed for non-enhancing tumor regions of non-glioblastoma multiforme (GBM) cases in patients with seizures (p = 0.022).CONCLUSION: DTI analyses in glioma patients demonstrated seizure-associated diffusion restrictions in certain tumor-related areas. No other structural abnormalities in adjacent or distant white matter or cortical regions were detected.
AB - INTRODUCTION: Structural white matter changes associated with certain epilepsy subtypes have been demonstrated using diffusion tensor imaging (DTI). This observational study aims to identify potential water diffusion abnormalities in glioma patients with associated seizures.METHODS: Two cohorts from two centers were analyzed independently: (A) Prospectively recruited patients diagnosed with glioma who received preoperative DTI to measure mean diffusivity (MD) and fractional anisotropy (FA) in regions-of-interest (ROIs) including the marginal tumor zone (TU), adjacent peritumoral white matter as well as distant ipsilateral and contralateral white matter and cortex. Data were compared between patients with and without seizures and tested for statistical significance. (B) A retrospective cohort using an alternative technical approach sampling ROIs in contrast enhancement, necrosis, non-enhancing tumor, marginal non-enhancing tumor zone, peritumoral tissue, edema and non-tumorous tissue.RESULTS: (A) The prospective study cohort consisted of 23 patients with 12 (52.2%) presenting with a history of seizures. There were no significant seizure-associated differences in MD or FA for non-tumor white matter or cortical areas. MD-TU was significantly lower in patients with seizures (p = 0.005). (B) In the retrospective cohort consisting of 46 patients with a seizure incidence of 50.0%, significantly decreased normalized values of MD were observed for non-enhancing tumor regions of non-glioblastoma multiforme (GBM) cases in patients with seizures (p = 0.022).CONCLUSION: DTI analyses in glioma patients demonstrated seizure-associated diffusion restrictions in certain tumor-related areas. No other structural abnormalities in adjacent or distant white matter or cortical regions were detected.
KW - Humans
KW - Diffusion Tensor Imaging/methods
KW - Retrospective Studies
KW - Prospective Studies
KW - Glioma/complications
KW - Anisotropy
KW - Seizures/diagnostic imaging
U2 - 10.1007/s11060-022-04139-9
DO - 10.1007/s11060-022-04139-9
M3 - SCORING: Journal article
C2 - 36344852
VL - 160
SP - 311
EP - 320
JO - J NEURO-ONCOL
JF - J NEURO-ONCOL
SN - 0167-594X
IS - 2
ER -
