Research ExplorerPublicationsDifferential Risk of Incident Alzheimer's Disease Dementia i...

Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline

Standard

Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline. / Wolfsgruber, Steffen; Kleineidam, Luca; Wagner, Michael; Mösch, Edelgard; Bickel, Horst; Lühmann, Dagmar; Ernst, Annette; Wiese, Birgitt; Steinmann, Susanne; König, Hans-Helmut; Brettschneider, Christian; Luck, Tobias; Stein, Janine; Weyerer, Siegfried; Werle, Jochen; Pentzek, Michael; Fuchs, Angela; Maier, Wolfgang; Scherer, Martin; Riedel-Heller, Steffi G; Jessen, Frank; AgeCoDe Study Group.

In: J ALZHEIMERS DIS, Vol. 54, No. 3, 04.10.2016, p. 1135-1146.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wolfsgruber, S, Kleineidam, L, Wagner, M, Mösch, E, Bickel, H, Lühmann, D, Ernst, A, Wiese, B, Steinmann, S, König, H-H, Brettschneider, C, Luck, T, Stein, J, Weyerer, S, Werle, J, Pentzek, M, Fuchs, A, Maier, W, Scherer, M, Riedel-Heller, SG, Jessen, F & AgeCoDe Study Group 2016, 'Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline', J ALZHEIMERS DIS, vol. 54, no. 3, pp. 1135-1146. https://doi.org/10.3233/JAD-160407

APA

Wolfsgruber, S., Kleineidam, L., Wagner, M., Mösch, E., Bickel, H., Lühmann, D., Ernst, A., Wiese, B., Steinmann, S., König, H-H., Brettschneider, C., Luck, T., Stein, J., Weyerer, S., Werle, J., Pentzek, M., Fuchs, A., Maier, W., Scherer, M., ... AgeCoDe Study Group (2016). Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline. J ALZHEIMERS DIS, 54(3), 1135-1146. https://doi.org/10.3233/JAD-160407

Vancouver

Wolfsgruber S, Kleineidam L, Wagner M, Mösch E, Bickel H, Lühmann D et al. Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline. J ALZHEIMERS DIS. 2016 Oct 4;54(3):1135-1146. https://doi.org/10.3233/JAD-160407

Bibtex

@article{60dadae857d74a8b978c450298fb4aa7,
title = "Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline",
abstract = "BACKGROUND: It is unknown whether longitudinal stability versus instability in subjective cognitive decline (SCD) is a modifying factor of the association between SCD and risk of incident Alzheimer's disease (AD) dementia.OBJECTIVE: We tested the modifying role of temporal stability of the SCD report on AD dementia risk in cognitively normal elderly individuals.METHODS: We analyzed data of 1,990 cognitively normal participants from the longitudinal AgeCoDe Study. We assessed SCD with/without associated worries both at baseline and first follow-up 18 months later. Participants were then classified either as (a) Controls (CO, with no SCD at both baseline and follow-up 1, n = 613), (b) inconsistent SCD (with SCD reported only at baseline or at follow-up 1, n = 637), (c) consistent SCD but without/or with inconsistent worries (n = 610) or (d) consistent SCD with worries (n = 130). We estimated incident AD dementia risk over up to 6 years for each group with Cox-Proportional Hazard Regression analyses adjusted for age, gender, education, ApoE4 status, and depression.RESULTS: Compared to CO, inconsistent SCD was not associated with increased risk of incident AD dementia. In contrast, risk was doubled in the group of consistent SCD without/ with inconsistent worries, and almost 4-fold in the group of consistent SCD with worries. These results could be replicated when using follow-up 1 to follow-up 2 response patterns for group definition.CONCLUSION: These findings suggest that longitudinal stability versus instability is an important modifying factor of the association between SCD and AD dementia risk. Worrisome SCD that is also consistently reported over time is associated with greatly increased risk of AD dementia.",
author = "Steffen Wolfsgruber and Luca Kleineidam and Michael Wagner and Edelgard M{\"o}sch and Horst Bickel and Dagmar L{\"u}hmann and Annette Ernst and Birgitt Wiese and Susanne Steinmann and Hans-Helmut K{\"o}nig and Christian Brettschneider and Tobias Luck and Janine Stein and Siegfried Weyerer and Jochen Werle and Michael Pentzek and Angela Fuchs and Wolfgang Maier and Martin Scherer and Riedel-Heller, {Steffi G} and Frank Jessen and {AgeCoDe Study Group}",
year = "2016",
month = oct,
day = "4",
doi = "10.3233/JAD-160407",
language = "English",
volume = "54",
pages = "1135--1146",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "3",

}

RIS

TY - JOUR

T1 - Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline

AU - Wolfsgruber, Steffen

AU - Kleineidam, Luca

AU - Wagner, Michael

AU - Mösch, Edelgard

AU - Bickel, Horst

AU - Lühmann, Dagmar

AU - Ernst, Annette

AU - Wiese, Birgitt

AU - Steinmann, Susanne

AU - König, Hans-Helmut

AU - Brettschneider, Christian

AU - Luck, Tobias

AU - Stein, Janine

AU - Weyerer, Siegfried

AU - Werle, Jochen

AU - Pentzek, Michael

AU - Fuchs, Angela

AU - Maier, Wolfgang

AU - Scherer, Martin

AU - Riedel-Heller, Steffi G

AU - Jessen, Frank

AU - AgeCoDe Study Group

PY - 2016/10/4

Y1 - 2016/10/4

N2 - BACKGROUND: It is unknown whether longitudinal stability versus instability in subjective cognitive decline (SCD) is a modifying factor of the association between SCD and risk of incident Alzheimer's disease (AD) dementia.OBJECTIVE: We tested the modifying role of temporal stability of the SCD report on AD dementia risk in cognitively normal elderly individuals.METHODS: We analyzed data of 1,990 cognitively normal participants from the longitudinal AgeCoDe Study. We assessed SCD with/without associated worries both at baseline and first follow-up 18 months later. Participants were then classified either as (a) Controls (CO, with no SCD at both baseline and follow-up 1, n = 613), (b) inconsistent SCD (with SCD reported only at baseline or at follow-up 1, n = 637), (c) consistent SCD but without/or with inconsistent worries (n = 610) or (d) consistent SCD with worries (n = 130). We estimated incident AD dementia risk over up to 6 years for each group with Cox-Proportional Hazard Regression analyses adjusted for age, gender, education, ApoE4 status, and depression.RESULTS: Compared to CO, inconsistent SCD was not associated with increased risk of incident AD dementia. In contrast, risk was doubled in the group of consistent SCD without/ with inconsistent worries, and almost 4-fold in the group of consistent SCD with worries. These results could be replicated when using follow-up 1 to follow-up 2 response patterns for group definition.CONCLUSION: These findings suggest that longitudinal stability versus instability is an important modifying factor of the association between SCD and AD dementia risk. Worrisome SCD that is also consistently reported over time is associated with greatly increased risk of AD dementia.

AB - BACKGROUND: It is unknown whether longitudinal stability versus instability in subjective cognitive decline (SCD) is a modifying factor of the association between SCD and risk of incident Alzheimer's disease (AD) dementia.OBJECTIVE: We tested the modifying role of temporal stability of the SCD report on AD dementia risk in cognitively normal elderly individuals.METHODS: We analyzed data of 1,990 cognitively normal participants from the longitudinal AgeCoDe Study. We assessed SCD with/without associated worries both at baseline and first follow-up 18 months later. Participants were then classified either as (a) Controls (CO, with no SCD at both baseline and follow-up 1, n = 613), (b) inconsistent SCD (with SCD reported only at baseline or at follow-up 1, n = 637), (c) consistent SCD but without/or with inconsistent worries (n = 610) or (d) consistent SCD with worries (n = 130). We estimated incident AD dementia risk over up to 6 years for each group with Cox-Proportional Hazard Regression analyses adjusted for age, gender, education, ApoE4 status, and depression.RESULTS: Compared to CO, inconsistent SCD was not associated with increased risk of incident AD dementia. In contrast, risk was doubled in the group of consistent SCD without/ with inconsistent worries, and almost 4-fold in the group of consistent SCD with worries. These results could be replicated when using follow-up 1 to follow-up 2 response patterns for group definition.CONCLUSION: These findings suggest that longitudinal stability versus instability is an important modifying factor of the association between SCD and AD dementia risk. Worrisome SCD that is also consistently reported over time is associated with greatly increased risk of AD dementia.

U2 - 10.3233/JAD-160407

DO - 10.3233/JAD-160407

M3 - SCORING: Journal article

C2 - 27567852

VL - 54

SP - 1135

EP - 1146

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 3

ER -