Differential effects to CCK-4-induced panic by dexamethasone and hydrocortisone.
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Differential effects to CCK-4-induced panic by dexamethasone and hydrocortisone. / Demiralay, Cüneyt; Jahn, Holger; Kellner, Michael; Yassouridis, Alexander; Wiedemann, Klaus.
In: WORLD J BIOL PSYCHIA, Vol. 13, No. 7, 7, 2012, p. 526-534.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Differential effects to CCK-4-induced panic by dexamethasone and hydrocortisone.
AU - Demiralay, Cüneyt
AU - Jahn, Holger
AU - Kellner, Michael
AU - Yassouridis, Alexander
AU - Wiedemann, Klaus
PY - 2012
Y1 - 2012
N2 - Peripheral administration of the cholecystokinin (CCK) receptor agonist CCK-4 generates panic and activates the hypothalamic-pituitary-adrenal (HPA) axis. Direct effects at the pituitary and CCK-HPA interactions at higher regulatory sites have been suggested. According to preliminary data, ACTH response to CCK receptor agonists may differ from its response to exogenous CRH by its resistance to cortisol feedback inhibition. To further explore this resistance and to better characterize CCK-4 sites of action, the effects of different glucocorticoid pretreatments on CCK-4-induced panic were compared.
AB - Peripheral administration of the cholecystokinin (CCK) receptor agonist CCK-4 generates panic and activates the hypothalamic-pituitary-adrenal (HPA) axis. Direct effects at the pituitary and CCK-HPA interactions at higher regulatory sites have been suggested. According to preliminary data, ACTH response to CCK receptor agonists may differ from its response to exogenous CRH by its resistance to cortisol feedback inhibition. To further explore this resistance and to better characterize CCK-4 sites of action, the effects of different glucocorticoid pretreatments on CCK-4-induced panic were compared.
KW - Adult
KW - Humans
KW - Male
KW - Severity of Illness Index
KW - Double-Blind Method
KW - Analysis of Variance
KW - Anti-Inflammatory Agents/pharmacology
KW - Adrenocorticotropic Hormone/blood
KW - Psychiatric Status Rating Scales/statistics & numerical data
KW - Panic Disorder/chemically induced/drug therapy
KW - Dexamethasone/pharmacology
KW - Hydrocortisone/blood/pharmacology
KW - Tetragastrin/pharmacology
KW - Adult
KW - Humans
KW - Male
KW - Severity of Illness Index
KW - Double-Blind Method
KW - Analysis of Variance
KW - Anti-Inflammatory Agents/pharmacology
KW - Adrenocorticotropic Hormone/blood
KW - Psychiatric Status Rating Scales/statistics & numerical data
KW - Panic Disorder/chemically induced/drug therapy
KW - Dexamethasone/pharmacology
KW - Hydrocortisone/blood/pharmacology
KW - Tetragastrin/pharmacology
M3 - SCORING: Journal article
VL - 13
SP - 526
EP - 534
JO - WORLD J BIOL PSYCHIA
JF - WORLD J BIOL PSYCHIA
SN - 1562-2975
IS - 7
M1 - 7
ER -