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Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC

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Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC. / Grothe, Michel J.; Moscoso, Alexis; Silva-Rodríguez, Jesús; Lange, Catharina; Nho, Kwangsik; Saykin, Andrew J.; Nelson, Peter T.; Schöll, Michael; Buchert, Ralph; Teipel, Stefan; Alzheimer’s Disease Neuroimaging Initiative.

In: ALZHEIMERS DEMENT, Vol. 19, No. 4, 04.2023, p. 1234-1244.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Grothe, MJ, Moscoso, A, Silva-Rodríguez, J, Lange, C, Nho, K, Saykin, AJ, Nelson, PT, Schöll, M, Buchert, R, Teipel, S & Alzheimer’s Disease Neuroimaging Initiative 2023, 'Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC', ALZHEIMERS DEMENT, vol. 19, no. 4, pp. 1234-1244. https://doi.org/10.1002/alz.12763

APA

Grothe, M. J., Moscoso, A., Silva-Rodríguez, J., Lange, C., Nho, K., Saykin, A. J., Nelson, P. T., Schöll, M., Buchert, R., Teipel, S., & Alzheimer’s Disease Neuroimaging Initiative (2023). Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC. ALZHEIMERS DEMENT, 19(4), 1234-1244. https://doi.org/10.1002/alz.12763

Vancouver

Grothe MJ, Moscoso A, Silva-Rodríguez J, Lange C, Nho K, Saykin AJ et al. Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC. ALZHEIMERS DEMENT. 2023 Apr;19(4):1234-1244. https://doi.org/10.1002/alz.12763

Bibtex

@article{5fa6339593214c879ed4e0cf6265569b,
title = "Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC",
abstract = "INTRODUCTION: Limbic age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy-derived fluorodeoxyglucose positron emission tomography (FDG-PET) signature of LATE-NC provides clinical utility for differential diagnosis of amnestic dementia patients.METHODS: Ante mortem FDG-PET patterns from autopsy-confirmed LATE-NC (N = 7) and AD (N = 23) patients were used to stratify an independent cohort of clinically diagnosed AD dementia patients (N = 242) based on individual FDG-PET profiles.RESULTS: Autopsy-confirmed LATE-NC and AD groups showed markedly distinct temporo-limbic and temporo-parietal FDG-PET patterns, respectively. Clinically diagnosed AD dementia patients showing a LATE-NC-like FDG-PET pattern (N = 25, 10%) were significantly older, showed less abnormal AD biomarker levels, lower APOE ε4, and higher TMEM106B risk allele load. Clinically, they exhibited a more memory-predominant profile and a generally slower disease course.DISCUSSION: An autopsy-derived temporo-limbic FDG-PET signature identifies older amnestic patients whose clinical, genetic, and molecular biomarker features are consistent with underlying LATE-NC.",
keywords = "amyloid, apolipoprotein E, autopsy, fluorodeoxyglucose positron emission tomography, hippocampal sclerosis, limbic age-related TDP-43 encephalopathy, tau, TDP-43, TMEM106B",
author = "Grothe, {Michel J.} and Alexis Moscoso and Jes{\'u}s Silva-Rodr{\'i}guez and Catharina Lange and Kwangsik Nho and Saykin, {Andrew J.} and Nelson, {Peter T.} and Michael Sch{\"o}ll and Ralph Buchert and Stefan Teipel and {Alzheimer{\textquoteright}s Disease Neuroimaging Initiative}",
year = "2023",
month = apr,
doi = "10.1002/alz.12763",
language = "English",
volume = "19",
pages = "1234--1244",
journal = "ALZHEIMERS DEMENT",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC

AU - Grothe, Michel J.

AU - Moscoso, Alexis

AU - Silva-Rodríguez, Jesús

AU - Lange, Catharina

AU - Nho, Kwangsik

AU - Saykin, Andrew J.

AU - Nelson, Peter T.

AU - Schöll, Michael

AU - Buchert, Ralph

AU - Teipel, Stefan

AU - Alzheimer’s Disease Neuroimaging Initiative

PY - 2023/4

Y1 - 2023/4

N2 - INTRODUCTION: Limbic age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy-derived fluorodeoxyglucose positron emission tomography (FDG-PET) signature of LATE-NC provides clinical utility for differential diagnosis of amnestic dementia patients.METHODS: Ante mortem FDG-PET patterns from autopsy-confirmed LATE-NC (N = 7) and AD (N = 23) patients were used to stratify an independent cohort of clinically diagnosed AD dementia patients (N = 242) based on individual FDG-PET profiles.RESULTS: Autopsy-confirmed LATE-NC and AD groups showed markedly distinct temporo-limbic and temporo-parietal FDG-PET patterns, respectively. Clinically diagnosed AD dementia patients showing a LATE-NC-like FDG-PET pattern (N = 25, 10%) were significantly older, showed less abnormal AD biomarker levels, lower APOE ε4, and higher TMEM106B risk allele load. Clinically, they exhibited a more memory-predominant profile and a generally slower disease course.DISCUSSION: An autopsy-derived temporo-limbic FDG-PET signature identifies older amnestic patients whose clinical, genetic, and molecular biomarker features are consistent with underlying LATE-NC.

AB - INTRODUCTION: Limbic age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy-derived fluorodeoxyglucose positron emission tomography (FDG-PET) signature of LATE-NC provides clinical utility for differential diagnosis of amnestic dementia patients.METHODS: Ante mortem FDG-PET patterns from autopsy-confirmed LATE-NC (N = 7) and AD (N = 23) patients were used to stratify an independent cohort of clinically diagnosed AD dementia patients (N = 242) based on individual FDG-PET profiles.RESULTS: Autopsy-confirmed LATE-NC and AD groups showed markedly distinct temporo-limbic and temporo-parietal FDG-PET patterns, respectively. Clinically diagnosed AD dementia patients showing a LATE-NC-like FDG-PET pattern (N = 25, 10%) were significantly older, showed less abnormal AD biomarker levels, lower APOE ε4, and higher TMEM106B risk allele load. Clinically, they exhibited a more memory-predominant profile and a generally slower disease course.DISCUSSION: An autopsy-derived temporo-limbic FDG-PET signature identifies older amnestic patients whose clinical, genetic, and molecular biomarker features are consistent with underlying LATE-NC.

KW - amyloid

KW - apolipoprotein E

KW - autopsy

KW - fluorodeoxyglucose positron emission tomography

KW - hippocampal sclerosis

KW - limbic age-related TDP-43 encephalopathy

KW - tau

KW - TDP-43

KW - TMEM106B

U2 - 10.1002/alz.12763

DO - 10.1002/alz.12763

M3 - SCORING: Journal article

C2 - 35971593

VL - 19

SP - 1234

EP - 1244

JO - ALZHEIMERS DEMENT

JF - ALZHEIMERS DEMENT

SN - 1552-5260

IS - 4

ER -