Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia.

M L Den Boer; R Pieters; K M Kazemier; Gritta Janka-Schaub; G Henze; U Creutzig; G J Kaspers; P R Kearns; A G Hall; A D Pearson; A J Veerman

Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia.

Standard

Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia. / Den Boer, M L; Pieters, R; Kazemier, K M; Janka-Schaub, Gritta; Henze, G; Creutzig, U; Kaspers, G J; Kearns, P R; Hall, A G; Pearson, A D; Veerman, A J.

In: BRIT J HAEMATOL, Vol. 104, No. 2, 2, 1999, p. 321-327.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Den Boer, ML, Pieters, R, Kazemier, KM, Janka-Schaub, G, Henze, G, Creutzig, U, Kaspers, GJ, Kearns, PR, Hall, AG, Pearson, AD & Veerman, AJ 1999, 'Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia.', BRIT J HAEMATOL, vol. 104, no. 2, 2, pp. 321-327. <http://www.ncbi.nlm.nih.gov/pubmed/10050715?dopt=Citation>

APA

Den Boer, M. L., Pieters, R., Kazemier, K. M., Janka-Schaub, G., Henze, G., Creutzig, U., Kaspers, G. J., Kearns, P. R., Hall, A. G., Pearson, A. D., & Veerman, A. J. (1999). Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia. BRIT J HAEMATOL, 104(2), 321-327. [2]. http://www.ncbi.nlm.nih.gov/pubmed/10050715?dopt=Citation

Vancouver

Den Boer ML, Pieters R, Kazemier KM, Janka-Schaub G, Henze G, Creutzig U et al. Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia. BRIT J HAEMATOL. 1999;104(2):321-327. 2.

Bibtex

@article{62c901749a3b4a9ab3e61a56f77c38a0,

title = "Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia.",

abstract = "Expression of three major classes of glutathione S-transferases (GSTs), i.e. alpha, mu and pi class, P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) were studied in childhood acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML) and normal peripheral blood lymphocytes by flow cytometry. In vitro cytotoxicity of 4-hydroxy-ifosfamide (IFOS), daunorubicin (DNR) and prednisolone (PRED) was assessed by the MTT assay. Expression of alpha, mu and pi class GST did not significantly differ between leukaemic cells from 100 initial and 14 unrelated relapse ALL patients (GSTalpha P=026; GSTmu P=O009; GSTpi P=0.13). The expression of GSTalpha (1.4-fold, P=0.0004), GSTpi (13-fold, P = 0001) and to a lesser extent also GSTmu (1.1-fold, P=0.03) was higher in ALL compared with normal peripheral blood lymphocytes. Expression of GSTmu and GST7pi was significantly higher in 18 AML compared with 100 ALL patients at initial diagnosis (respectively 1.3-fold, P=0.0005 and 2-fold, P",

author = "{Den Boer}, {M L} and R Pieters and Kazemier, {K M} and Gritta Janka-Schaub and G Henze and U Creutzig and Kaspers, {G J} and Kearns, {P R} and Hall, {A G} and Pearson, {A D} and Veerman, {A J}",

year = "1999",

language = "Deutsch",

volume = "104",

pages = "321--327",

journal = "BRIT J HAEMATOL",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

number = "2",

}

RIS

TY - JOUR

T1 - Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia.

AU - Den Boer, M L

AU - Pieters, R

AU - Kazemier, K M

AU - Janka-Schaub, Gritta

AU - Henze, G

AU - Creutzig, U

AU - Kaspers, G J

AU - Kearns, P R

AU - Hall, A G

AU - Pearson, A D

AU - Veerman, A J

PY - 1999

Y1 - 1999

N2 - Expression of three major classes of glutathione S-transferases (GSTs), i.e. alpha, mu and pi class, P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) were studied in childhood acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML) and normal peripheral blood lymphocytes by flow cytometry. In vitro cytotoxicity of 4-hydroxy-ifosfamide (IFOS), daunorubicin (DNR) and prednisolone (PRED) was assessed by the MTT assay. Expression of alpha, mu and pi class GST did not significantly differ between leukaemic cells from 100 initial and 14 unrelated relapse ALL patients (GSTalpha P=026; GSTmu P=O009; GSTpi P=0.13). The expression of GSTalpha (1.4-fold, P=0.0004), GSTpi (13-fold, P = 0001) and to a lesser extent also GSTmu (1.1-fold, P=0.03) was higher in ALL compared with normal peripheral blood lymphocytes. Expression of GSTmu and GST7pi was significantly higher in 18 AML compared with 100 ALL patients at initial diagnosis (respectively 1.3-fold, P=0.0005 and 2-fold, P

AB - Expression of three major classes of glutathione S-transferases (GSTs), i.e. alpha, mu and pi class, P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) were studied in childhood acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML) and normal peripheral blood lymphocytes by flow cytometry. In vitro cytotoxicity of 4-hydroxy-ifosfamide (IFOS), daunorubicin (DNR) and prednisolone (PRED) was assessed by the MTT assay. Expression of alpha, mu and pi class GST did not significantly differ between leukaemic cells from 100 initial and 14 unrelated relapse ALL patients (GSTalpha P=026; GSTmu P=O009; GSTpi P=0.13). The expression of GSTalpha (1.4-fold, P=0.0004), GSTpi (13-fold, P = 0001) and to a lesser extent also GSTmu (1.1-fold, P=0.03) was higher in ALL compared with normal peripheral blood lymphocytes. Expression of GSTmu and GST7pi was significantly higher in 18 AML compared with 100 ALL patients at initial diagnosis (respectively 1.3-fold, P=0.0005 and 2-fold, P

M3 - SCORING: Zeitschriftenaufsatz

VL - 104

SP - 321

EP - 327

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 2

M1 - 2

ER -